A5074041722- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Smoking Behavior and Cessation
- Neuroinflammation and Neurodegeneration Mechanisms
- Amino Acid Enzymes and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
University of Minnesota
2023-2025
Arizona State University
2016-2019
Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and cystine-glutamate exchange protein xCT within nucleus accumbens core (NAcore). N-acetylcysteine (NAC) has been shown to restore these proteins in a rodent model drug addiction relapse. However, specific molecular mechanisms driving its inhibitory effects on cue-induced nicotine reinstatement are unknown. Here, we confirm that extinction nicotine-seeking behavior impaired NAcore...
Abstract Women report greater craving during certain phases of the menstrual cycle. As well, research indicates that pharmacotherapies for smoking may be less efficacious in women compared with men, which due to interactions natural fluctuations ovarian hormone levels. N ‐Acetylcysteine (NAC) is a glutamatergic compound has shown some efficacy treating substance use disorders and aids prevention relapse. However, it unclear whether NAC sex‐specific effectiveness nicotine relapse treatment....
Abstract Accumulating evidence has revealed the existence of functional astrocyte-neuron communication based on ability astrocytes to respond neurotransmitters and release gliotransmitters. However, little is known about how other signaling molecules, such as hormones, impact astrocyte function. Estradiol (E2) an important hormone regulate neuronal activity, synaptic transmission, plasticity, animal behavior. whether E2 specifically signals in situ consequences remain unknown. Therefore, we...
N-acetylcysteine (NAC), a promising glutamatergic therapeutic agent, has shown some clinical efficacy in reducing nicotine use humans and been to reverse drug-induced changes neurophysiology. In rats, nicotine-seeking behavior is associated with alterations plasticity within the nucleus accumbens core (NAcore). Specifically, cue-induced rapid, transient synaptic (t-SP) synapses on NAcore medium spiny neurons. The goal of present study was determine if NAC reduces reverses...