A5057550036- Neuroblastoma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Cellular Mechanics and Interactions
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Blood Coagulation and Thrombosis Mechanisms
- Extracellular vesicles in disease
- Antimicrobial Peptides and Activities
- Blood disorders and treatments
- Protein Degradation and Inhibitors
- Immunodeficiency and Autoimmune Disorders
- Erythrocyte Function and Pathophysiology
- Infant Nutrition and Health
- RNA Interference and Gene Delivery
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Nonmelanoma Skin Cancer Studies
- Testicular diseases and treatments
- Alcoholism and Thiamine Deficiency
- Glioma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Autophagy in Disease and Therapy
- Acute Myocardial Infarction Research
Bangkok Hospital
2024
Ramathibodi Hospital
2019-2024
Mahidol University
2019-2024
Patients with severe thalassemia commonly have a survival that is significantly shorter than of the general population. Allogeneic hematopoietic stem cell transplantation (allo-SCT) only established treatment potentially curative, but it limited by availability donors and medical condition patient. To expand donor pool to include haploidentical related donors, we introduced program consisting pharmacologic pretransplant immune suppression phase (PTIS) 2 courses dexamethasone fludarabine,...
MYCN amplification is the strongest predictor of high-risk neuroblastoma (NB). The standard procedure to detect status requires invasive procedures. Extracellular vesicles (EVs) contain molecular signatures originated cells, present in biofluids, and serve as an invaluable source for cancer liquid biopsies. This study aimed establish EV-based method NB. Two EV subtypes, i.e., microvesicles (MVs) exosomes, were sequentially isolated from culture supernatant by step-wise centrifugation,...
Liquid biopsy involves the utilization of minimally invasive or noninvasive techniques to detect biomarkers in biofluids for disease diagnosis, monitoring, guiding treatments. This approach is promising early diagnosis childhood cancer, especially brain tumors, where tissue biopsies are more challenging and cause late detection. Extracellular vesicles offer several characteristics that make them ideal resources cancer liquid biopsy. nanosized particles, primarily secreted by all cell types...
IntroductionThe diagnosis of pediatric pulmonary embolism (PE) is often delayed due to non-specific symptoms, and clinical prediction tools designed for adults are unsuitable children. This study aimed create a PE predictive model evaluate the reported in Thai population.Material methodsA multi-center retrospective from 4 university hospitals included children ≤18 years age undergoing computed tomography angiogram 2000 2020 with suspicion PE. Patients' presentations risk factors venous...
Background 131 I-meta-iodo-benzylguanidine ( I-mIBG) therapy has been used in treatment of for advanced neuroblastoma many years with promising results. There are several studies regarding predictors and outcomes I-mIBG therapies relapsed/refractory patients. Objective To identify the neuroblastoma. Methods This study was a retrospective review 22 patients high risk stage IV who received at least one cycle therapy. Patient’ characteristics, hematologic toxicity, scintigraphic...
Induction chemotherapy with carboplatin followed by radiotherapy has been used for many years treating intracranial germ-cell tumors (IC-GCTs) in Thailand. The objective of this study was to assess treatment outcomes, focusing on survival and ototoxicity.The outcomes all patients IC-GCT treated at Ramathibodi Hospital the Prasat Neurological Institute between 2000 2017 were reviewed analyzed, including patient characteristics modalities. Five-year overall (OS) event-free (EFS) analyzed using...
Chemotherapy in childhood leukemia is associated with late morbidity leukemic survivors, while certain patient subsets are relatively resistant to standard chemotherapy. It therefore important identify new agents sensitivity and selectivity towards cells, having less systemic toxicity. Peptide-based therapeutics has gained a great deal of attention during the last few years. Here, we used an integrative workflow combining mass spectrometric peptide library construction, silico anticancer...
Abstract Background Neuroblastoma is the most common extracranial malignant solid tumor during childhood. Despite intensified treatment, patients with high‐risk neuroblastoma (HR‐NBL) still carry a dismal prognosis. The Thai Pediatric Oncology Group (ThaiPOG) proposed use of multimodality treatment to improve outcomes HR‐NBL in non‐immunotherapy settings. Methods Patients undergoing ThaiPOG protocols (ThaiPOG‐NB‐13HR or ‐18HR) between 2013 and 2019 were retrospectively reviewed. Patient...
Abstract Background Congenital neutropenia is a rare disease. Recurrent infections since young age are the presentation. The most common mutation causing severe congenital (SCN) and cyclic (CyN) ELANE gene. objectives of this study were to screen three genetic mutations , HAX1 GFI1 in children with chronic describe clinical characteristics who had mutations. Methods Infants having ANC < 1,000/cu mm or aged > 1 year 1,500/cu at least 3 times months enrolled study. Patients acquired due...
Wiskott-Aldrich syndrome (WAS)/X-linked thrombocytopenia (XLT) is a rare X-linked disease characterized by thrombocytopenia, eczema, and recurrent infection. In addition, WAS/XLT increases incidence of autoimmune diseases malignancies. We reported 7 male patients, 2 with WAS 5 XLT, from 6 different families. Two novel mutations, p.Gly387GlufsTer58 p.Ala134Asp, were identified in patients WAS. Both had severe clinical phenotypes compatible classic developed lethal outcomes intracranial...
: This study evaluates factors associated with globe preservation and long-term visual outcomes according to clinical characteristics treatment modalities in intraocular retinoblastoma patients. A retrospective review of medical records enrolled patients between January 1, 2007, June 30, 2020. •Setting: Single-centered •Patient or population: Intraocular treated at Ramathibodi Hospital, Bangkok, Thailand. •Main outcome measure: statistically significant factor prognosis corresponds baseline...
ABSTRACT Introduction Ph‐like ALL has gene expression profile similar to Ph‐positive but without the BCR::ABL1 fusion. The disease presents higher rates of severe clinical features and is associated with unfavorable outcomes. There still no standard pipeline for molecular characterization disease, valid predictor panel available worldwide. Methods We performed microarray on 25 B‐cell 6 cluster identify transcriptional signature ALL. qRT‐PCR was used confirm candidate genes. Results Four out...
Transcobalamin deficiency is a rare inborn metabolic disorder, characterized by pancytopenia, megaloblastic anemia, failure to thrive, diarrhea, and psychomotor retardation.We describe patient who first presented at 3 months of age, with hepatosplenomegaly, recurrent infection, acidosis, acute hemolytic crisis. Extensive hematologic immunologic investigations did not identify inherited bone marrow syndrome, leukemia or its related disorders. Whole exome sequencing identified novel homozygous...
Abstract Severe congenital neutropenia (SCN)/cyclic (CyN), a rare disease, is caused by ELANE or ELA2 gene mutations. The study reported that 4 children (2 SCN and 2 CyN) presented with recurrent infections. two novel mutations, p. Ala79del p.Val197GlufsTer18, in exons 3 4, were identified, causing CyN, respectively. One patient the longest follow-up time of 12.9 years developed MDS/AML complex karyotypes SETBP1 (c.2602G > A, p.D868N) NRAS (c.34G p.G12S) was successfully treated...
Abstract BACKGROUND MGA-NUTM1 fusion gene tumor are recently described as new subtype of NUTM1-rearranged tumors. Regarding its rarity, standard treatment has not been reported. Here we clinical presentation, radiologic finding, immunohistological profile, and a boy with tumor. CASE REPORT: A 13-year-old 2-month history progressive right hemiparesis headache. Magnetic resonance imaging (MRI) revealed 7.8 x10.6 x 8.0 cm well defined heterogeneous enhancing mass at left fronto-parietal lobe....
Abstract Chemotherapy in childhood leukemia is associated with late morbidity leukemic survivors, while certain patient subsets are relatively resistant to standard chemotherapy. It therefore important identify new agents sensitivity and selectivity towards cells, having less systemic toxicity. Peptide-based therapeutics has gained much attention during the last few years. Here, we used an integrative workflow combining mass spectrometric peptide library construction, silico anticancer...
Wiskott-Aldrich syndrome (WAS)/X-linked thrombocytopenia (XLT) is a rare X-linked disease characterized by thrombocytopenia, eczema, and recurrent infection. In addition, WAS/XLT increases incidence of autoimmune diseases malignancies. We reported 7 male patients, 2 with WAS 5 XLT, from 6 different families. Two novel mutations, p.Gly387GlufsTer58 p.Ala134Asp, were identified in patients WAS. Both had severe clinical phenotypes compatible classic developed lethal outcomes intracranial...