A5080797609- Genomics and Phylogenetic Studies
- Actinomycetales infections and treatment
- Microbial Natural Products and Biosynthesis
- Stroke Rehabilitation and Recovery
- Mycobacterium research and diagnosis
- Infectious Disease Case Reports and Treatments
- Synthetic Organic Chemistry Methods
- Microbial Community Ecology and Physiology
- Infectious Diseases and Mycology
- Cystic Fibrosis Research Advances
- Plant Disease Resistance and Genetics
- Protist diversity and phylogeny
- Infections and bacterial resistance
- Acute Ischemic Stroke Management
- Plant Pathogens and Fungal Diseases
- Marine Sponges and Natural Products
- Kidney Stones and Urolithiasis Treatments
- Palliative Care and End-of-Life Issues
- Burkholderia infections and melioidosis
- Infective Endocarditis Diagnosis and Management
- Lichen and fungal ecology
- Streptococcal Infections and Treatments
- Dementia and Cognitive Impairment Research
- Asymmetric Synthesis and Catalysis
- Ureteral procedures and complications
Northumbria University
2014-2025
Sunshine Coast University Hospital
2024
Royal Botanic Garden Edinburgh
2024
St. George's University
2024
Hospital of the University of Pennsylvania
2024
Sandia National Laboratories
2023
Royal Hallamshire Hospital
1997-2022
Axsome Therapeutics (United States)
2022
Seattle Children's Hospital
2007-2021
University of Otago
2021
Biodiversity genomics research requires reliable organismal identification, which can be difficult based on morphology alone. DNA-based identification using DNA barcoding provide confirmation of species identity and resolve taxonomic issues but is rarely used in studies generating reference genomes. Here, we describe the development implementation for Darwin Tree Life Project (DToL), aims to sequence assemble high quality genomes all eukaryotic Britain Ireland. We present a standardised...
Objective: Altered glutamatergic neurotransmission has been implicated in the pathogenesis of depression. This trial evaluated efficacy and safety AXS-05 (dextromethorphan-bupropion), an oral N-methyl-D-aspartate (NMDA) receptor antagonist σ1 agonist, treatment major depressive disorder (MDD). Methods: double-blind, phase 3 trial, was conducted between June 2019 December 2019. Patients with a DSM-5 diagnosis MDD were randomized 1:1 ratio to receive dextromethorphan-bupropion (45 mg-105 mg...
Burkholderia pseudomallei is the causative agent of melioidosis, a disease being increasingly recognized as an important cause morbidity and mortality in many regions world. Several features melioidosis suggest that B. facultative intracellular pathogen. This study was designed to assess ability invade survive eukaryotic cells. We have shown has capacity cultured cell lines, including HeLa, CHO, A549, Vero demonstrated survival professional phagocytic cells, rat alveolar macrophages. B...
A paired comparison experiment is described in which preferences for Munsell colour patches were elicited from 54 subjects. Value, chroma, and hue examined separately, Individuals differed their value also hue. There sex differences preference. Overall the majority of subjects showed a preference blue hues dislike yellow hues, thus demonstrating continuity between animal human aesthetics.
Abstract Background Despite national recommendations, as of 2009 human papillomavirus (HPV) vaccination rates were low with < 30% adolescent girls fully vaccinated. Research on barriers to has focused separately parents, adolescents, or clinicians and not the decision making process among all participants at point care. By incorporating three distinct perspectives, we sought generate hypotheses inform interventions increase vaccine receipt. Methods Between March June, 2010, conducted...
Prokaryotic systematics provides the fundamental framework for microbiological research but remains a discipline that relies on labour- and time-intensive polyphasic taxonomic approach, including DNA-DNA hybridization, variation in 16S rRNA gene sequence phenotypic characteristics. These techniques suffer from poor resolution distinguishing between closely related species often result misclassification misidentification of strains. Moreover, guidelines are unclear delineation bacterial...
International stroke care guidelines recommend the routine assessment and management of psychological emotional problems post-stroke. Understanding experiences those delivering receiving these services is vital to improving provision support post-stroke.To explore patients', carers', health professionals' need, assessment, post-stroke while in hospital immediately post-discharge.Participants were recruited from seven specialist north England. Qualitative semi-structured interviews focus...
Three strains, designated as J27, J71 T and J72, belonging to the genus Antrihabitans , were isolated from stable foams formed in activated sludge wastewater treatment plants (WWTPs) New South Wales, Australia. Phenotypic genomic analyses revealed that these strains belong Nocardiaceae family are closely related stalagmiti . However, distinct physiological characteristics, including overall relatedness indices, phylogenomic analysis, metabolic profiles MALDI-TOF MS (Matrix-Assisted Laser...
The aims of this qualitative study were to identify patients’ and family members’ experiences acute stroke their preferences for end-of-life care. Twenty-eight purposely sampled patients with an who had high (n = 13) low 15) disability selected from 191 sequential cases admitted two general hospitals in north-east England. In addition, 25 members other recruited. Views about current services care elicited semi-structured interviews. Communication between healthcare professionals was...
Contamination of drinking water by microorganisms and arsenic represents a major human health hazard in many parts the world. An estimated 3.4 million deaths year are attributable to waterborne diseases. Arsenic poisoning from contaminated sources is causing emergency some countries such as Bangladesh where 35 77 people at risk. The World Health Organization (WHO) has recently recognized point-of-use treatment an effective means reducing illness developing country households. A new system...
An actinomycete isolated from an immunocompetent patient suffering confluent and reticulated papillomatosis was characterized using a polyphasic taxonomic approach. The organism had chemotaxonomic morphological properties that were consistent with its assignment to the genus Dietzia it formed distinct phyletic line within 16S rRNA gene tree. It shared sequence similarity of 98.3 % nearest neighbour, type strain cinnamea, could be distinguished strains all species combination phenotypic...
Background: despite a mortality rate of approximately 30% in acute stroke, little is known about the palliative care needs this group patients. Design: prospective study 191 stroke patients admitted to hospital England. Biographical, medical and stroke-related data were collected. Participants completed Sheffield Profile for Assessment Referral Care (SPARC), screening tool referral specialist care. Findings: over 50% reported moderate significant fatigue-related problems. Approximately...
Pseudomonas pseudomallei is the causative agent of melioidosis, a disease being increasingly recognized as an important cause morbidity and mortality in many regions world. An intriguing observation regarding melioidosis that significant percentage patients who develop have preexisting diabetes mellitus. In this regard, we tested hypothesis insulin may modulate growth P. pseudomallei. We demonstrated markedly inhibits vitro vivo. The rate minimal medium containing human recombinant was...
The increasing prevalence of Staphylococcus aureus strains isolated from hospital- and community-acquired respiratory tract infections is an important public health concern worldwide. majority S. produce staphylokinase, a plasminogen activator capable inactivating neutrophil alpha-defensins impairing phagocytosis via opsonin degradation. Cathelicidin antimicrobial peptides are present at sites infection before the release alpha-defensins. Therefore, we hypothesized that staphylokinase...
With the dramatic increase in incidence of food allergies, nurses and other school personnel are likely to encounter a child with allergies. The objectives this study were assess effectiveness in-person training on enhancing knowledge about allergies improving self-confidence preventing, recognizing, treating allergy reactions collect information prior participation response incidents. A total 4,818 individuals at 247 schools community sites participated program, which was delivered by...
Opinion 106 of the Judicial Commission has clarified nomenclature taxon variously named Rhodococcus equi , ‘Prescottella ’ and hoagii . As a consequence, we present here genus name Prescottella that its nomenclatural type species, comb. nov., for valid publication propose reclassification four rhodococcal species as novel combinations in genus, namely agglutinans Guo et al. 2015 defluvii Kämpfer al 2014 soli Li nov. subtropica Lee 2019 In addition, note clinical isolate, strain 86–07...