A5013268507- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Epigenetics and DNA Methylation
- Essential Oils and Antimicrobial Activity
- Bioactive natural compounds
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Metabolism, Diabetes, and Cancer
- Cancer-related gene regulation
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Bioactive Natural Diterpenoids Research
- Histone Deacetylase Inhibitors Research
- Phytochemical compounds biological activities
- Allelopathy and phytotoxic interactions
- Cancer Research and Treatments
- Phytochemical and Pharmacological Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Ginger and Zingiberaceae research
- Dengue and Mosquito Control Research
- Phytochemistry and Bioactivity Studies
- Ginkgo biloba and Cashew Applications
- Ubiquitin and proteasome pathways
Government College University, Faisalabad
2018-2023
Khwaja Fareed University of Engineering and Information Technology
2022
Tufts University
2019
Jean Mayer Human Nutrition Research Center on Aging
2019
University of Miami
2019
COVID-19, a rapidly spreading new strain of coronavirus, has affected more than 150 countries and received worldwide attention. The lack efficacious drugs or vaccines against SARS-CoV-2 further worsened the situation. Thus, there is an urgent need to boost up research for development effective therapeutics affordable diagnostic COVID-19. crystallized form main protease (Mpro) was demonstrated by Chinese researcher Liu et al. (2020) which novel therapeutic drug target. This study conducted...
Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is a pharmacologically active flavone which has been isolated from variety of medicinal plants. known to possess various pharmacological properties such as anti-cancer, anti-oxidant, and anti-inflammatory. It speculated that eupatilin could be subjected structural optimization for the synthesis derivative analogs reinforce its efficacy, minimize toxicity, optimize absorption profiles, will ultimately lead towards potent drug candidates....
Pyruvate kinase (PK), a key enzyme that determines glycolytic activity, has been known to support the metabolic phenotype of tumor cells, and specific pyruvate isoform M2 (PKM2) reported fulfill divergent biosynthetic energetic requirements cancerous cells. PKM2 is overexpressed in several cancer types an emerging drug target for during recent years. Therefore, this study was carried out identify inhibitors from natural products treatment. Based on objectives study, firstly, plant extract...
Nature has provided prodigious reservoirs of pharmacologically active compounds for drug development since times. Physcion and physcion 8-O-β-D-glucopyranoside (PG) are bioactive natural anthraquinones which exert anti-inflammatory anticancer properties with minimum or no adverse effects. Moreover, also exhibits anti-microbial hepatoprotective properties, while PG is known to have anti-sepsis as well ameliorative activities against dementia. This review aims highlight the sources...
Resistance development against some frequently used insecticides, i.e., deltamethrin (1.5% EC), cypermethrin (10% SC), permethrin (0.5% WP) and DDVP (50% EC) was evaluated Musca domestica L. Insecticide bioassays were carried out susceptible resistant strains at 2.5, 5, 10, 20 40 µg/µl concentrations.Mortality data recorded after 24, 48 72 hours.Resistance monitored up to three generations the flies with higher LD 50 values than F1 generation considered resistant.LD for Permethrin increased...
Nature, an expert craftsman of molecules, has generated extensive array bioactive molecular entities. It persists as inexhaustible resource for discovery drugs and supplied enormous scaffold diversification development into effectual to treat multiple pathological conditions. This review provides update on the sources, biological, pharmacological effects nature's gift, a triterpenoid saponin, tubeimoside-1 which is major constituent bulb Bolbostemma paniculatum. Tubeimoside-1 known possess...
The reliance of tumor cells on aerobic glycolysis is one the emerging hallmarks cancer. Pyruvate kinase M2 (PKM2), an important enzyme glycolytic pathway, highly expressed in a number cancer cells. Tumor heavily depend PKM2 to fulfill their divergent energetic and biosynthetic requirements, suggesting it as novel drug target for therapies. Based this context, we performed enzymatic-assay-based screening in-house phenolic compounds library identification inhibitors. This identified silibinin,...