A5101544783- Optical Coherence Tomography Applications
- Biosensors and Analytical Detection
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Medical Imaging Techniques and Applications
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- Higher Education and Teaching Methods
- Antibiotics Pharmacokinetics and Efficacy
- Enzyme Production and Characterization
- Ultrasonics and Acoustic Wave Propagation
- Advanced biosensing and bioanalysis techniques
- Ion Channels and Receptors
- Education and Work Dynamics
- Advanced X-ray and CT Imaging
- Analytical chemistry methods development
- Image and Signal Denoising Methods
- Radiation Dose and Imaging
- Polysaccharides and Plant Cell Walls
- Mycotoxins in Agriculture and Food
- Meat and Animal Product Quality
- Structural Health Monitoring Techniques
- Marine Toxins and Detection Methods
- Blind Source Separation Techniques
- Fermentation and Sensory Analysis
Hebei Agricultural University
2014-2025
Shenzhen Bay Laboratory
2023-2025
Construction Development (Qatar)
2025
Beijing Institute of Technology
2025
Zhuhai People's Hospital
2023-2025
Jinan University
2023-2025
Ocean University of China
2007-2023
University of Hong Kong
2001-2023
Changsha University of Science and Technology
2010-2023
Chinese University of Hong Kong
2006-2023
Abstract With the emergence of multidrug-resistant bacteria, antimicrobial peptides (AMPs) offer promising options for replacing traditional antibiotics to treat bacterial infections, but discovering and designing AMPs using methods is a time-consuming costly process. Deep learning has been applied de novo design address AMP classification with high efficiency. In this study, several natural language processing models were combined identify AMPs, i.e. sequence generative adversarial nets,...
[reaction: see text] New air-stable PdCl(2){P(t)Bu(2)(p-R-Ph)}(2) (R = H, NMe(2), CF(3),) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl heteroatom-substituted six-membered chlorides with a diverse range arylboronic acids. High product yields (89-99% isolated yields) turn-over-numbers (10,000 TON) are observed.
In this study, scallop mantle protein was treated by ultrasound at different powers, and then analyzed ANS fluorescent probes, circular dichroism spectroscopy, endogenous fluorescence spectrum, DNTB colorimetry in-vitro digestion model to elucidate the structure-function relationship. The results indicated that can significantly affect secondary structure of like enhancing hydrophobicity, lowering particle size, increasing relative contents α-helix decreasing β-pleated sheet, β-turn random...
In this paper, we report what believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT).Using confocal optics on sample arm, scanned illumination beam across under-filled objective lens pupil plane by steering at pinhole using microcylindrical lens.The detected interferometric signals from multiple distinctive apertures were digitally refocused, which analogous synthetic aperture radar (SAR).Using numerical simulations and imaging...
It has been suggested that the helix–loop–helix protein Id-1 plays an important role in tumourigenesis certain types of human cancer. Previously, we reported was up-regulated during sex hormone-induced prostate carcinogenesis a Noble rat model (Ouyang et al . (2001) Carcinogenesis , 22 965–973). In present study, investigated direct effect expression on cancer cell proliferation by transfecting vector into line LNCaP. Ten stable transfectant clones were isolated and ectopic resulted both...
The vanilloid receptor-1 (TRPV1 or VR1) is a member of the transient receptor potential (TRP) family ion channels and plays role in regulating function sensory nerves. A growing body evidence demonstrates therapeutic TRPV1 modulators, particularly management pain. As result our screening efforts, we identified (E)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (1), an antagonist that blocks capsaicin-induced pH-induced uptake (45)Ca(2+) TRPV1-expressing Chinese...
The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis structure-activity relationships series 2-(4-pyridin-2-ylpiperazin-1-yl)-1H-benzo[d]imidazoles as novel antagonists. Compound 46ad was among most potent analogues this series. This compound...
Transient receptor potential vanilloid 1 (TRPV1) channel antagonists may have clinical utility for the treatment of chronic nociceptive and neuropathic pain. We recently advanced a TRPV1 antagonist, 3 (AMG 517), into trials as new therapy However, in addition to desired analgesic effects, this antagonist significantly increased body core temperature following oral administration rodents. Here, we report one our approaches eliminate or minimize on-target hyperthermic effect observed with...