A5040744435- Thyroid Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Neurological disorders and treatments
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Advanced Neuroimaging Techniques and Applications
- Genetic factors in colorectal cancer
- Neonatal Respiratory Health Research
- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Growth Hormone and Insulin-like Growth Factors
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Parkinson's Disease Mechanisms and Treatments
China Medical University
2011-2019
First Hospital of China Medical University
2011-2017
Liaoning University of Traditional Chinese Medicine
2011
Maternal hypothyroidism has adverse effects on neural development in the offspring. The present study aimed to investigate whether maternal subclinical impairs spatial learning offspring, as well efficacy and optimal time of levothyroxine (L-T(4)) treatment pregnancy. Female adult Wistar rats were randomly divided into six groups (n = 10 per group): control, hypothyroid (H), (SCH) SCH treated with L-T(4), starting from tenth, thirteenth seventeenth gestational day (GD10, GD13 GD17),...
The mammalian target of rapamycin (mTOR)/eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) pathway plays a critical role in cell growth, survival and angiogenesis, has been demonstrated to correlate with human epidermal growth receptor 2 (HER2) status. Neoadjuvant chemotherapy (NAC), also known as preoperative therapy, is now well established the treatment inoperable locally advanced inflammatory breast cancer. In vitro study shown that mTOR inhibitors, together...