Short non-lethal ischemic episodes administered to hearts prior (ischemic preconditioning, IPC) or directly after postconditioning, IPost) events facilitate myocardial protection. Transferring coronary effluent collected during IPC treatment un-preconditioned recipient protects from lethal insults. We propose that contains hydrophobic cytoprotective mediators acting via PI3K/Akt-dependent pro-survival signaling at reperfusion. Ex vivo rat were subjected 30 min of regional ischemia and 120...

Exposure to early life stress may profoundly influence the developing brain in lasting ways. Neuropsychiatric disorders associated with adversity involve neural changes reflected EEG power as a measure of activity and disturbed sleep. The main aim present study was for first time characterize possible adult after postnatal maternal separation rats. Furthermore, same animals, we investigated how sleep architecture were affected exposure chronic mild protocol. During day 2-14 male rats exposed...

Light can be used to facilitate alertness, task performance and circadian adaptation during night work. Novel strategies for illumination of workplaces, using ceiling mounted LED-luminaires, allow the use a range different light conditions, altering intensity spectral composition. This study (ClinicalTrials.gov Identifier NCT03203538) investigated effects short-wavelength narrow-bandwidth (λmax = 455 nm) compared long-wavelength 625 nm), with similar photon density (~2.8 × 1014...

Objectives To investigate how a standard ceiling mounted light-emitting diode (LED)-based bright light intervention affected alertness and neurobehavioural performance during three consecutive simulated night shifts, timing of circadian rhythm after the shifts. Methods Twenty seven participants (20 females, 21.4±2.1 years; mean±SD) worked shifts (23:00–07:00) under full-spectrum (4000 K) (900 lx) (90 condition in counterbalanced crossover design (separated by 4 weeks). Subjective (Karolinska...

Millions of people worldwide work during the night, resulting in disturbed circadian rhythms and sleep loss. This may cause deficits cognitive functions, impaired alertness increased risk errors accidents. Disturbed rhythmicity from night shift could impair brain function cognition through disrupted synthesis proteins involved synaptic plasticity neuronal function. Recently, transcription factor brain-and-muscle arnt-like protein 1 (BMAL1) has been identified as a promoter mRNA translation...

Night-shift work is linked to a shift in food intake toward the normal sleeping period, and metabolic disturbance. We applied rat model of night-shift assess immediate effects such on metabolism. Male Wistar rats were subjected 8 h forced activity during their rest (ZT2-10) or active (ZT14-22) phase. Food intake, body weight, temperature monitored across four days eight recovery days. gradually shifted rest-work hours, stabilizing day three. A subgroup animals was euthanized after third...

Use of blue-enriched light has received increasing interest regarding its activating and performance sustaining effects. However, studies assessing effects such during night work are few, novel strategies for lighting using emitting diode (LED) technology need to be researched. In a counterbalanced crossover design, we investigated the standard polychromatic white (7000 K; ~ 200 lx) compared warm (2500 K), similar photon density (~ 1.6 x 1014 photons/cm2/s), three consecutive simulated...

Millions of people worldwide are working at times that overlap with the normal time for sleep. Sleep problems related to work schedule may mediate well-established relationship between shift and increased risk disease, occupational errors accidents. Yet, our understanding causality underlying mechanisms explain this is limited. We aimed assess consequences night-shift sleep examine whether work-induced disturbances yield electrophysiological markers impaired maintenance waking brain state....

Sexual abuse contributes to the development of multiple forms psychopathology, including anxiety and depression, but extent which genetics these disorders among sexual victims remains unclear. In this translational study, we first examined gene expression in brains rodents exposed different early-life conditions (long, brief or no maternal separation). Hypothesizing that genes revealing changes may have relevance for psychiatric symptoms later life, possible association those with depression...

Background: Brain-derived neurotrophic factor (BDNF) expression, which can be measured in blood serum, has been found to increase with aerobic exercise. The link between BDNF level, physical exercise, and genetic status (Val66Met polymorphism) not well researched older adults. Objective: To investigate the possible acute Val66Met polymorphism Method: Twenty-three healthy adults participated one session of Their serum levels were both at baseline post Saliva samples collected identify each...

The circadian system develops and changes in a gradual programmed process over the lifespan. Early life, maternal care represents an important zeitgeber thus contributes to development of rhythmicity. Exposure early life stress may affect processes induce latent disturbance evident after exposure later stress. Disturbance normal regulation rhythmicity is surmised be etiological factor depression. We used postnatal separation rats investigate how environment might modify response...

Abstract Background Gene therapeutic strategies with suicide genes are currently investigated in clinical trials for brain tumors. Previously, we have shown that lentiviral vectors delivering the gene HSV‐Tk to experimental tumors promote a highly significant treatment effect and thus promising translation. Methods In present study, tested HSV‐Tk.007, active mutant of HSV‐Tk, rat brains as preclinical toxicity study. We injected 10 6 vesicular stomatitis virus glycoprotein (VSV‐G)...

Abstract Many occupations require operations during the night-time when internal circadian clock promotes sleep, in many cases resulting impairments cognitive performance and brain functioning. Here, we use a rat model to attempt identify biological mechanisms underlying such impaired performance. Rats were exposed forced activity, either their rest-phase (simulating night-shift work; rest work) or active-phase day-shift active work). Sleep, wakefulness body temperature rhythm monitored...

Millions of people work at times that overlap with the habitual time for sleep. Consequently, sleep often occurs during day. Daytime is, however, characterized by reduced duration. Despite preserved spent in deep NREM (stage N3), daytime is subjectively rated as less restorative. Knowledge on how night influences homeostatic pressure limited. Therefore, we aimed to explore effect three consecutive simulated shifts and markers homeostasis.We performed continuous EEG, EMG EOG recordings...

Millions of people worldwide are required to work when their physiology is tuned for sleep. By forcing wakefulness out the body's normal schedule, shift workers face numerous adverse health consequences, including gastrointestinal problems, sleep and higher rates some diseases, cancers. Recent studies have developed protocols simulate in rodents with intention assessing effects night-shift on subsequent (Grønli et al., 2017). These already provided important contributions understanding...

Night work leads to sleepiness and reduced vigilant attention during hours, bright light interventions may reduce such effects. It is also known that total sleep deprivation impairs cognitive flexibility as measured by reversal learning tasks. Whether night task performance or if can mitigate deficits unclear. In this counterbalanced crossover study (ClinicaTrials.gov Identifier NCT03203538), young healthy individuals completed a twice each of three consecutive simulated shifts (23:00–07:00...

Malignant gliomas, the largest group of primary intracerebral tumours, are one most difficult-to-cure cancers. For glioblastoma, malignant form glioma, median survival time is generally less than year. Lentiviral vector mediated suicide gene therapy has been reported to be a potential therapeutic option for glioma and validated in clinically relevant animal models. At this end, specific targeting tumor cells sparing normal brain tissue significant concern. Although several studies may...