A5012870282- HIV/AIDS drug development and treatment
- Lung Cancer Treatments and Mutations
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- HIV Research and Treatment
- Complement system in diseases
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Antifungal resistance and susceptibility
- Malaria Research and Control
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Research Studies
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- HIV/AIDS Research and Interventions
- Mosquito-borne diseases and control
- Pneumonia and Respiratory Infections
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Blood groups and transfusion
- Prostate Cancer Treatment and Research
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Adenosine and Purinergic Signaling
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2017-2024
University Hospital and Clinics
2021-2024
Radboud Institute for Molecular Life Sciences
2018-2024
Erasmus MC
2023
Rotterdam University of Applied Sciences
2023
Meander Medisch Centrum
2011-2016
Slotervaartziekenhuis
2003-2011
The Netherlands Cancer Institute
2010
Abstract Background Older age is associated with increased severity and death from respiratory infections, including coronavirus disease 2019 (COVID-19). The tuberculosis BCG vaccine may provide heterologous protection against nontuberculous infections has been proposed as a potential preventive strategy COVID-19. Methods In this multicenter, placebo-controlled trial, we randomly assigned older adults (aged ≥60 years; n = 2014) to intracutaneous vaccination (n 1008) or placebo 1006). primary...
The development of model-informed precision dosing (MIPD) tools, especially in the form native or web-based applications to be used at bedside, has garnered marked attention recent years. Their potential clinical benefit can large, but it should ensured that such tools make optimal use available data and have adequate predictive ability. Unique scientific challenges specific MIPD remain, which may require adaptation commonly diagnostics pharmacometrics.
Capsid virus-like particles (cVLP) have proven safe and immunogenic can be a versatile platform to counter pandemics. We aimed clinically test modular cVLP COVID-19 vaccine in individuals who were naive SARS-CoV-2.In this phase 1, single-centre, dose-escalation, adjuvant-selection, open-label clinical trial, we recruited participants at the Radboud University Medical Center Nijmegen, Netherlands, sequentially assigned them seven groups. Eligible healthy, aged 18-55 years, tested negative for...
BackgroundMalaria elimination requires interruption of the highly efficient transmission Plasmodium parasites by mosquitoes. TB31F is a humanised monoclonal antibody that binds gamete surface protein Pfs48/45 and inhibits fertilisation, thereby preventing further parasite development in mosquito midgut onward transmission. We aimed to evaluate safety efficacy malaria-naive participants.MethodsIn this open-label, first-in-human, dose-escalation, phase 1 clinical trial, healthy, malaria-naive,...
Abstract For the quantification of all currently approved non‐nucleoside reverse transcriptase inhibitors and protease inhibitors, including new inhibitor darunavir active nelfinavir metabolite M8, an assay was developed, using liquid chromatography coupled with tandem mass spectrometry. The sample pretreatment consisted a protein precipitation mixture methanol acetonitrile only 100 µL plasma. Chromatographic separation performed on reversed‐phase C18 column (150 × 2.0 mm, particle size 5...
Abstract Purpose: To enhance the systemic exposure to oral docetaxel by coadministration of ritonavir, an efficacious inhibitor CYP 3A4 with minor P-glycoprotein inhibiting effects, in patients cancer. Experimental Design: A proof-of-concept study was carried out 12 solid tumors. The first cohort (n = 4) received 10 mg and subsequent 8) 100 docetaxel, coadministered ritonavir randomized simultaneously or given 60 minutes before on days 1 8. On day 15 22, i.v. docetaxel. Results: area under...
Lopinavir is extensively metabolized by cytochrome P450 3A (CYP3A) and considered to be a substrate for the drug transporters ABCB1 (P-glycoprotein) ABCC2 (MRP2). Here, we have assessed individual combined effects of CYP3A, on pharmacokinetics lopinavir relative importance intestinal hepatic metabolism. We also evaluated whether ritonavir increases oral bioavailability inhibition and/or ABCC2.Lopinavir transport was measured in Madin-Darby canine kidney cells expressing or ABCC2. Oral...
The introduction of eculizumab has improved the outcome in patients with atypical hemolytic uremic syndrome (aHUS). optimal treatment strategy is debated. Here, we report results CUREiHUS study, a 4-year prospective, observational study monitoring unbiased discontinuation Dutch aHUS after 3 months therapy. All pediatric and adult native kidneys first-time were evaluated. In addition, an extensive cost-consequence analysis was conducted. A total 21 included from January 2016 to October 2020....
BackgroundArtemether–lumefantrine is widely used for uncomplicated Plasmodium falciparum malaria; sulfadoxine–pyrimethamine plus amodiaquine seasonal malaria chemoprevention. We aimed to determine the efficacy of artemether–lumefantrine with and without primaquine tafenoquine reducing gametocyte carriage transmission mosquitoes.MethodsIn this phase 2, single-blind, randomised clinical trial conducted in Ouelessebougou, Mali, asymptomatic individuals aged 10–50 years P gametocytaemia were...
ABSTRACT Low-dose primaquine is recommended to prevent Plasmodium falciparum malaria transmission in areas threatened by artemisinin resistance and aiming for elimination. Community treatment campaigns with artemisinin-based combination therapy the gametocytocidal dose target all age groups, but no studies thus far have assessed pharmacokinetics of this drug African children. We recruited 40 children participating a efficacy trial Burkina Faso study pharmacokinetics. These received...
Treatment of animal models with ataxia telangiectasia (A-T) nicotinamide riboside (NR) improved their neurological outcome and survival.
Pyronaridine-artesunate is the most recently licensed artemisinin-based combination therapy. WHO has recommended that a single low dose of primaquine could be added to therapies reduce
BackgroundTafenoquine was recently approved as a prophylaxis and radical cure for Plasmodium vivax infection, but its falciparum transmission-blocking efficacy is unclear. We aimed to establish the safety of three single low doses tafenoquine in combination with dihydroartemisinin–piperaquine reducing gametocyte density transmission mosquitoes.MethodsIn this four-arm, single-blind, phase 2, randomised controlled trial, participants were recruited at Clinical Research Unit Malaria Training...
It is unknown whether ustekinumab (UST) levels can predict clinical outcomes in Crohn's disease (CD) patients. We assessed the exposure–response relationship of UST trough concentrations with biochemical at week 24 a prospective, real-world setting. performed prospective study patients CD starting four academic centres Netherlands. All received weight-adjusted intravenous (IV) induction dose, followed by one subcutaneous (SC) dose 90 mg 8 weeks. Maintenance therapy consisted every or 12...
<h2>Abstract</h2> The haemolytic uraemic syndromes (HUS) are a heterogeneous group of conditions only some which mediated by complement (CaHUS). We report the outcome 2023 International Society Nephrology HUS Forum where global panel experts considered current state art, identified areas uncertainty, and proposed optimal solutions. Areas uncertainty for future research included: nomenclature HUS; novel testing strategies; identification biomarkers; genetic predisposition to aHUS; dosing...