A5101913938- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- vaccines and immunoinformatics approaches
- Microbial Metabolites in Food Biotechnology
- T-cell and B-cell Immunology
- Seaweed-derived Bioactive Compounds
- Hepatitis B Virus Studies
- Immune cells in cancer
- Natural Antidiabetic Agents Studies
- Cancer Research and Treatments
- Nutrition, Health and Food Behavior
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Food Quality and Safety Studies
- Hepatitis Viruses Studies and Epidemiology
- Bioactive natural compounds
- Esophageal and GI Pathology
- Breast Lesions and Carcinomas
- Bladder and Urothelial Cancer Treatments
- Ginseng Biological Effects and Applications
- Morinda citrifolia extract uses
- Renal cell carcinoma treatment
- Diet and metabolism studies
Songdo Hospital
2023-2024
Sungkyunkwan University
2004-2023
Pharmicell (South Korea)
2016-2023
Kangbuk Samsung Hospital
2023
King's College London
2023
Pusan National University
2015-2021
Chungnam National University
2019
Samsung Medical Center
2004-2015
Environmental Research Institute
2015
WonKwang Health Science University
2015
Abstract Oncolytic virotherapy is a promising alternative to conventional treatment, yet systemic delivery of these viruses tumors remains major challenge. In this regard, mesenchymal stem cells (MSC) with well-established tumor-homing property could serve as tool. We showed that MSCs be effectively infected by hepatocellular carcinoma (HCC)-targeted oncolytic adenovirus (HCC-oAd) through modification the virus' fiber domain and virus replicated efficiently in cell carrier. HCC-targeting oAd...
To date, no adjuvant treatment has been shown to have a clear benefit in patients with hepatocellular carcinoma (HCC). In this prospective phase I/IIa study, we evaluated the safety and efficacy of dendritic cell (DC) therapy HCC who received primary for HCC. Twelve had viable tumour after treatments were included. Dendritic vaccines pulsed cytoplasmic transduction peptide-attached alpha-fetoprotein, glypican-3 melanoma-associated antigen 1 recombinant fusion proteins injected subcutaneously...
Abstract Background Ten cancer patients (Six renal cell carcinoma and four breast patients) were treated in a phase I/II study with vaccine composed of autologous dendritic cells (DCs) IL-2 to evaluate the DC vaccine-related toxicity antigen-specific immune alteration. Methods Cancer twice CD34 + hematopoietic stem cell-derived, GM-CSF/IFN-γ-differentiated DCs pulsed tumor lysate KLH, by 4-week interval. Following each subcutaneous injection therapeutic DCs, low-dose (200 MIU) was introduced...
Cancer is one of the leading causes morbidity and mortality worldwide; therefore there a need to discover new therapeutic modules with improved efficacy safety. Immune-(cell) therapy promising strategy for treatment intractable cancers. The effectiveness certain chemotherapeutics in inducing immunogenic tumor cell death thus promoting cancer eradication has been reported. Ginsenoside Rg3 ginseng saponin that antitumor immunomodulatory activity. In this study, we treated cells verify...
2,7″-Phloroglucinol-6,6'-bieckol is a type of phlorotannin isolated from brown algae, Ecklonia cava Kjellman (Phaeophyceae; Laminareaceae). mediates antioxidant activities. However, there has been no research on improving postprandial hyperglycaemia using 2,7″-phloroglucinol-6,6'-bieckol.
This study aimed to investigate the inhibition activities of lupeol on carbohydrate digesting enzymes and its ability improve postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. α-Glucosidase α-amylase inhibitory assays were executed using a chromogenic method. The effect after meal was measured by blood glucose STZ-induced normal mice treated orally with soluble starch (2 g/kg BW) alone (control) or (10 mg/kg acarbose dissolved water. Blood samples taken from tail...
The anti-tumor effect of monocyte-derived DC (MoDC) vaccine was studied in lung cancer model with feasible but weak Ag-specific immune response and incomplete blocking tumor growth. To overcome this limitation, the hematopoietic stem cell-derived (SDC) cultured MoDC & SDC compared mouse minimal residual (MRD). Therapeutic DCs were from either CD34(+) cells GM-CSF, SCF IL-4 for 14 days or monocytes GM-CSF 7 (MoDC). injected twice by one week interval into peritoneum mice that are inoculated...
Many cancer types are serious diseases causing mortality, and new therapeutics with improved efficacy safety required. Immuno-(cell)-therapy is considered as one of the promising therapeutic strategies for curing intractable cancer. In this study, we tested R2016, a newly developed heterocyclic quinone derivative, induction immunogenic tumor cell death possible novel immunochemotherapeutic. We studied anti-cancer effects R2016 against LLC, lung line B16F10, melanoma line. LLC...
Scope Evidence on the Mediterranean diet (MD) and age‐related cognitive decline (CD) is still inconclusive partly due to self‐reported dietary assessment. The aim of current study develop an MD‐ metabolomic score (MDMS) investigate its association with CD in community‐dwelling older adults. Methods results This includes participants from Three‐City Study Bordeaux ( n = 418) Dijon 422) cohorts who are free dementia at baseline. Repeated measures cognition over 12 years collected. An MDMS...
We examined whether the organ microenvironment modulates metastatic behavior and response to doxorubicin (DXR) in murine renal carcinoma (RENCA) cells. Tumor cells were injected into kidney (orthotopic) subcutis (ectopic) of syngeneic mice. Lung metastases developed up 57% (17/30) animals having tumors but not those with skin tumors. Tumors growing more resistant DXR than when mice given intravenous injections (8 mg/kg) on days 8 15 after implantation. In addition, tumor cultured from...
EY-6 is one of the newly synthesized indoledione derivatives to induce tumor cell-specific cell death. In this study, we investigated mechanism immunological death induced by at mouse colon cancer as well normal immune represented dendritic cell.C57BL/6 syngeneic MC38 was treated with EY-6, and analyzed MTT for viability test, flow cytometry confirming surface expressing molecules ELISA detection cytokine secretion. Normal myeloid-dendritic (DC) ex vivo cultured from bone marrow...
Purpose: Dendritic cell (DC) vaccination for melanoma was introduced because carries distinct tumor-associated antigens.The purpose of this study to investigate the efficacy and safety DC in Korea.Materials Methods: Five patients with stage IV one II were enrolled.Autologous monocyte-derived DCs (MoDCs) cultured pulsed tumor-lysate, keyhole limpet hemocyanin, cytokine cocktail mature antigen-loaded DC.DC repeated four times at 2-week intervals 2-4×10 7 injected each time.Results: Reduced...
Abstract Background: Dendritic cells (DCs) can effectively mediate the prevention and regression of a variety solid tumors. However, not much has been determined about their efficacy for squamous cell carcinoma (SCC), partly because there are no known tumor‐specific antigens or low immunogenicity this tumor. The authors aimed to determine preventive effect DC‐based immunotherapy in SCC animal model. Methods: Bone marrow derived DCs C3H/He mice were pulsed with ultraviolet–B‐irradiated...
Abstract Dendritic cell (DC)-based immunotherapies have been shown to be a potential treatment option for various cancers; however, the exact strategies in ovarian cancer remain unknown. Here, we report effectiveness of mouse CD8α+ DCs derived from bone marrow hematopoietic stem cells (BM-HSCs), equivalent human CD141+ DCs, which proven highly superior subset. Mono-DCs monocytes and stem-DCs HSCs were characterized by CD11c+ CD80+ CD86+ Clec9a+ expression, respectively. Despite lower dose...
Colorectal cancer (CRC) is the most frequent with limited therapeutic achievements. Recently, adoptive cellular immunotherapy has been developed as an antitumor therapy. However, its efficacy not tested in CRC. This study investigated ability of immune cell cocktail dendritic cells (DCs), T cells, and natural killer (NK) to overcome immunological hurdles improve therapy for
The immunological death induction by EY-6 on the human tumor cell lines was screened. Human colon carcinoma (HCT15, HCT116), gastric (MKN74, SNU668), and myeloma (KMS20, KMS26, KMS34) cells were died treatment with dose-dependent manner. CRT expression, a typical marker for death, increased EY-6-treated colorectal cancer cells. Interestingly, effects complicated showing line dependent differential modulation. Cytokine secretion from treated dose cell-dependent. IFN-γ IL-12 in (200% to over...