A5002587321- International Relations and Foreign Policy
- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Cardiomyopathy and Myosin Studies
- Signaling Pathways in Disease
- Vietnamese History and Culture Studies
- Cardiac Fibrosis and Remodeling
- Diatoms and Algae Research
- Cardiac electrophysiology and arrhythmias
- International Development and Aid
- Mitochondrial Function and Pathology
- Korean Peninsula Historical and Political Studies
- Economic Zones and Regional Development
- Chinese history and philosophy
- Experimental Learning in Engineering
- Global trade and economics
- China's Socioeconomic Reforms and Governance
- American Constitutional Law and Politics
- Cardiovascular Effects of Exercise
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- Asian Geopolitics and Ethnography
- Engineering Education and Pedagogy
- Malaria Research and Control
Boston College
2002-2024
University of California, San Diego
2013-2023
United States Department of Veterans Affairs
2009-2023
VA San Diego Healthcare System
2011-2023
Johns Hopkins University
2000-2021
North Florida/South Georgia Veterans Health System
2021
University of Detroit Mercy
2002-2020
Ford Motor Company (France)
2020
American Society For Engineering Education
2015-2020
Wayne State University
2020
This highly readable book makes a strong case that Washington establishment does exist and members of Congress are responsible for it. Fiorina's description the self-serving interconnections have developed between Congress, bureaucrats, citizens with special interests leads to provocative disturbing conclusions about way our political system works. First published in 1977, this greatly enlarged second edition discusses new developments occurred over past twelve years, provides supportive...
To study the mechanisms that activate expression of atrial natriuretic factor (ANF) gene during pressure-induced hypertrophy, we have developed and characterized an in vivo murine model myocardial cell hypertrophy. We employed microsurgical techniques to produce a stable 35- 45-mmHg pressure gradient across thoracic aorta mouse is associated with rapid transient immediate-early program (c-fos/c-jun/junB/Egr-1/nur-77), increase heart weight/body weight ratio, up-regulation endogenous ANF...
In migrating cells, integrin-based focal adhesions (FAs) assemble in protruding lamellipodia association with rapid filamentous actin (F-actin) assembly and retrograde flow. How dynamic F-actin is coupled to FA not known. We analyzed the role of vinculin integrating dynamics by gene disruption primary fibroblasts. Vinculin slowed flow maturing establish a lamellipodium–lamellum border generate high extracellular matrix (ECM) traction forces. addition, promoted nascent formation turnover...
Inflammation is associated with cardiac remodeling and heart failure, but how it initiated in response to nonischemic interventions the absence of cell death not known. We tested hypothesis that activation Ca2+/calmodulin-dependent protein kinase II δ (CaMKIIδ) cardiomyocytes (CMs) pressure overload elicits inflammatory responses leading adverse remodeling.Mice which CaMKIIδ was selectively deleted from CMs (cardiac-specific knockout [CKO]) floxed control mice were subjected transverse...
Integrins link the extracellular matrix to cellular cytoskeleton and serve important roles in cell growth, differentiation, migration, survival. Ablation of β1 integrin all murine tissues results peri-implantation embryonic lethality. To investigate role myocardium, we used Cre-LoxP technology inactivate gene exclusively ventricular cardiac myocytes. Animals with homozygous myocyte excision were born appropriate numbers grew into adulthood. These animals had 18% control levels β1D protein...
To study the mechanisms which mediate transcriptional activation of cardiac genes during alpha adrenergic stimulation, present examined regulated expression three genes, a ventricular embryonic gene (atrial natriuretic factor, ANF), constitutively expressed contractile protein (cardiac MLC-2), and sodium channel gene. 1-Adrenergic stimulation activates release ANF from neonatal cells. As assessed by RNase protection analyses, treatment with alpha-adrenergic agonists increases steady-state...
April 01 1999 The Geography of the Peace: East Asia in Twenty-first Century Robert S. Ross is Professor Political Science, Boston College, and Associate John King Fairbank Center for Asian Research, Harvard University. His most recent books are Great Wall Empty Fortress: China's Search Security (coauthor) (New York: W.W. Norton, 1997) Negotiating Cooperation: U.S.-China Relations, 1969-1989 (Stanford, Calif.: Stanford University Press, 1995). other works by this author on: This Site Google...
Abstract —Multiple signaling pathways have been implicated in the hypertrophic response of ventricular myocytes, yet importance cell-matrix interactions has not extensively examined. Integrins are cell-surface molecules that link extracellular matrix to cellular cytoskeleton. They can function as cell and transducers mechanical information noncardiac cells. Given these properties their abundance cardiac cells, we evaluated hypothesis β 1 integrin is involved α -adrenergic mediated neonatal...
Vinculin is a ubiquitously expressed multiliganded protein that links the actin cytoskeleton to cell membrane. In myocytes, it localized in complexes which anchor contractile apparatus sarcolemma. Its function myocardium remains poorly understood. Therefore, we developed mouse model with cardiac-myocyte-specific inactivation of vinculin (Vcl) gene by using Cre-loxP technology. Sudden death was found 49% knockout (cVclKO) mice younger than 3 months age despite preservation function. Conscious...
This is the first comprehensive check-list of diatoms British Isles to cover all currently reported taxa from freshwater, brackish and marine habitats. It contains a classification genera in order families, followed by complete list species lower set out alphabetical within each genus. The two main orders Diatomaceae are represented in:- 5 sub-orders, 20 3 sub-families, 152 genera, 1798 species, 6 sub-species, 745 varieties 73 forms. also includes 2048 synonyms formerly common use, together...
Abstract Realists agree that great powers balance the military power of rising powers, but there is little agreement regarding secondary-state responses to powers. First, are differences whether secondary states or accommodate Second, among realists distinct roles economic and factors in alignment policies. Third, some scholars argue state alignments not necessarily determined by realist variables, can reflect preferences shaped intentions, historical experiences, cultural influences. This...
The excitation-contraction coupling cycle in cardiac muscle is initiated by an influx of Ca2+ through voltage-dependent channels. induces a release from the sarcoplasmic reticulum and myocyte contraction. To maintain homeostasis, entry balanced efflux mediated sarcolemmal Na+-Ca2+ exchanger. In absence exchange, it would be expected that myocytes overload with Ca2+. Using Cre/loxP technology, we generated mice cardiac-specific knockout exchanger, NCX1. exchanger completely ablated 80% to 90%...
Recent developments in Chinese politics and defense policy indicate that China will soon embark on an ambitious maritime include construction of a power-projection navy centered aircraft carrier. But just as nationalism the pursuit status encouraged past land powers to seek great power capabilities, widespread nationalism, growing social instability, leadership's concern for its political legitimacy drive China's naval ambition. power, however, be limited by constraints experienced all...