A5024170941- Fire effects on ecosystems
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Evolution and Paleontology Studies
- Animal Ecology and Behavior Studies
- Asthma and respiratory diseases
- interferon and immune responses
- Influenza Virus Research Studies
- Pediatric health and respiratory diseases
- Vector-borne infectious diseases
- Wildlife Ecology and Conservation
University of Louisville
2013-2019
Northern Michigan University
2014
In vitro, ribavirin acts as a lethal mutagen in Hantaan virus (HTNV)-infected Vero E6 cells, resulting an increased mutation load and viral population extinction. this study, we asked whether treatment the lethal, suckling mouse model of HTNV infection would act similarly. The genomic RNA (vRNA) copy number infectious were measured lungs untreated ribavirin-treated mice. untreated, HTNV-infected mice, vRNA for 10 days postinfection (dpi) thereafter remained constant through 26 dpi....
To capture the possible genotypic and phenotypic differences of 2009 influenza A virus H1N1 pandemic (H1N1pdm) strains circulating in adult hospitalized patients, we isolated sequenced nine H1N1pdm viruses from patients during 2009–2010 with severe pneumonia Kentucky. Each viral isolate was characterized mice along two additional one seasonal strain to assess replication virulence. All isolates showed similar levels nasal turbinates lung, but varied their ability cause morbidity. Further...
Four of the nine sigmodontine tribes have species that serve as reservoirs rodent-borne hantaviruses (RBO-HV), few been studied in any depth. Several viruses associated with human cases hantavirus pulmonary syndrome often through peridomestic exposure. Jabora (JABV) and Juquitiba (JUQV), harbored by Akodon montensis Oligoryzomys nigripes, respectively, are endemic sympatric Reserva Natural de Bosque Mbaracayú (RNBM), Paraguay, a protected area Interior Atlantic Forest. Rodent communities...
Small mammal communities in the Neotropics are composed largely of sigmodontine rodents. However, many questions regarding these remain unanswered, especially those pertaining to fine-scale sympatry and habitat selection. To address this, we examined community structure vegetation western margin Upper Paraná Atlantic Forest southwestern-most extent Cerrado (CE) (an extensive South American savanna ecoregion) Paraguay. Vegetation classifications were derived from satellite imagery combined...
Hantaviruses productively infect endothelial cells in their rodent reservoirs and humans, but the infection only causes disease humans – hantavirus pulmonary syndrome hemorrhagic fever with renal syndrome. Despite enormous progress that has been made understanding pathogenesis immune responses of infection, there is a large gap our molecular-based knowledge hantaviral proteins structures, functions mechanisms facilitate entry, replication assembly. Importantly, we know little about specific...