A5090373059- Cervical and Thoracic Myelopathy
- Diet and metabolism studies
- Autoimmune and Inflammatory Disorders
- Adipose Tissue and Metabolism
- Spinal Cord Injury Research
- Facial Nerve Paralysis Treatment and Research
- Infectious Diseases and Tuberculosis
- Neurogenesis and neuroplasticity mechanisms
- Aortic Disease and Treatment Approaches
Island Hospital
2024
International Collaboration On Repair Discoveries
2014-2017
University of British Columbia
2014-2017
Because of the complex, multifaceted nature spinal cord injury (SCI), it is widely believed that a combination approaches will be superior to individual treatments. Therefore, we employed rat model cervical SCI evaluate four noninvasive treatments individually have been reported effective for acute during clinically relevant therapeutic time windows. These included ghrelin, ibuprofen, C16, and ketogenic diet (KD). were selected not only because their previously efficacy in models but also...
We have previously reported that administration of a CD11d monoclonal antibody (mAb) improves recovery in clip-compression model SCI. In this the mAb reduces infiltration activated leukocytes into injured spinal cord (as indicated by reduced intraspinal MPO). However not all anti-inflammatory strategies beneficial results, suggesting success treatment may depend on type or severity injury. therefore tested rat hemi-contusion cervical contrast to its effects model, did improve forelimb...
Lay Summary We present the first documented case of successful treatment orofacial granulomatosis by intralesional injections a tumor necrosis factor α inhibitor to lip. Our patient had rapid symptomatic improvement after 3 injections, and near resolution within 4 months anti-tumor therapy.