A5044080990- Thyroid Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Glutathione Transferases and Polymorphisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- BRCA gene mutations in cancer
- Risk Perception and Management
- Military History and Strategy
- Medical Malpractice and Liability Issues
- Ethics and Legal Issues in Pediatric Healthcare
- Critical Theory and Philosophy
- Obstructive Sleep Apnea Research
- Asian American and Pacific Histories
- Anesthesia and Pain Management
- Intensive Care Unit Cognitive Disorders
- Religious Studies and Spiritual Practices
- Cancer Mechanisms and Therapy
- Dementia and Cognitive Impairment Research
- Pediatric Pain Management Techniques
- Cancer-related cognitive impairment studies
- Gothic Literature and Media Analysis
- South Asian Studies and Conflicts
- Theology and Philosophy of Evil
- War, Ethics, and Justification
- Patient-Provider Communication in Healthcare
Temple College
2018
Temple University
2018
Pennsylvania State University
2016-2017
Penn State Milton S. Hershey Medical Center
2016
Anaplastic thyroid cancer (ATC) comprises approximately 2% of all cancers, and its median survival rate remains poor. It is responsible for more than one third cancer-related deaths. ATC frequently resistant to conventional therapy, NFκB signaling has been proposed be a feature the disease. We aimed assess activity antimalaria drug quinacrine known target in combination with clinically relevant kinase inhibitor sorafenib cells. The presence NFκB-p65/RELA MCL1 was demonstrated by meta-data...
To establish a time frame for postoperative improvements in neurocognitive function patients who undergo parathyroidectomy primary hyperparathyroidism by utilizing repeat neuropsychological assessment at multiple points before and after surgery.Prospective cohort study.A prospective study was conducted tertiary academic medical center between August 2014 December 2015, including 50 with underwent parathyroidectomy. A panel of tests administered two separate points: preoperative 1-week...
To determine if decisional regret (DR) in parents following tonsillectomy/adenotonsillectomy (TA) their children is related to preoperative conflict, perceived outcome of surgery, complications or other factors.Observational analytic cohort study.Tertiary care children's hospital.Preoperative conflict (DC) and SURE tests were administered a parent child scheduled for TA between July 2014 2015. The DR given 1 3 months postoperatively. Data collected on patient age, sex, (including bleeding),...
In 1979, Three Mile Island (TMI) nuclear power plant experienced a partial meltdown with release of radioactive material. The effects the accident on thyroid cancer (TC) in surrounding population remain unclear. Radiation-induced TCs have lower incidence single nucleotide oncogenic driver mutations and higher gene fusions. We used next generation sequencing (NGS) to identify molecular signatures radiation-induced TC cohort patients residing near TMI during time accident.Case series.We...
BackgroundA number of different treatment regimens have been described for post-operative pain management pediatric tonsillectomy following the widespread discontinuation use codeine due to safety concerns. However, literature is lacking with regard relative efficacy regimens. This study designed determine effectiveness an intraoperative dose intravenous acetaminophen management.MethodsRecords were reviewed patients undergoing a single surgeon between 2012 and 2014. Pain scores, need...
<p>Supplementary materials Material and Methods Supplemental Figure 1: Quantitative assessment of mRNA expression Mcl-1, RelA Stat3 in anaplastic thyroid carcinoma (ATC) cell lines resected ATC's using qRT-PCR. 2: Expressions NF�B-p65 Stat3pY ATC. 3: Assessment medical staining parameters relationship to the overall survival (OS) ATC cohort. 4: Meta analysis previously published profiles on ATC's. 5: Model schematic displaying drug synergy from combination sorafenib/quinacrine...
<div>Abstract<p><b>Purpose and Experimental Design:</b> Anaplastic thyroid cancer (ATC) comprises approximately 2% of all cancers, its median survival rate remains poor. It is responsible for more than one third cancer–related deaths. ATC frequently resistant to conventional therapy, NFκB signaling has been proposed be a feature the disease. We aimed assess activity antimalaria drug quinacrine known target in combination with clinically relevant kinase inhibitor...
<div>Abstract<p><b>Purpose and Experimental Design:</b> Anaplastic thyroid cancer (ATC) comprises approximately 2% of all cancers, its median survival rate remains poor. It is responsible for more than one third cancer–related deaths. ATC frequently resistant to conventional therapy, NFκB signaling has been proposed be a feature the disease. We aimed assess activity antimalaria drug quinacrine known target in combination with clinically relevant kinase inhibitor...
<p>Supplementary materials Material and Methods Supplemental Figure 1: Quantitative assessment of mRNA expression Mcl-1, RelA Stat3 in anaplastic thyroid carcinoma (ATC) cell lines resected ATC's using qRT-PCR. 2: Expressions NF�B-p65 Stat3pY ATC. 3: Assessment medical staining parameters relationship to the overall survival (OS) ATC cohort. 4: Meta analysis previously published profiles on ATC's. 5: Model schematic displaying drug synergy from combination sorafenib/quinacrine...
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