A5061470216- HIV/AIDS drug development and treatment
- Spectroscopy and Chemometric Analyses
- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Cytomegalovirus and herpesvirus research
- Biochemical and Molecular Research
Merck & Co., Inc., Rahway, NJ, USA (United States)
2020-2024
Salisbury University
2012
The combination of laboratory automation and data-rich experimentation has led to significant improvements in experimental efficiency, reproducibility, throughput compared conventional methods. These transformative technologies have proven particularly valuable drug substance process characterization studies, where the ability rapidly generate volumes reaction data maximize understanding for ever-increasing regulatory expectations is paramount importance. highly dense sets offer potential...
We report the practical synthesis of a key fragment islatravir (MK-8591), novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) currently under investigation for treatment and pre-exposure prophylaxis (PrEP) against HIV infection. The fragment, unnatural nucleobase 2-fluoroadenine, is incorporated into MK-8591 via biocatalytic aldol-glycosylation cascade, which imposes stringent requirements its isolation. Presented herein development work leading to practical, scalable...