Abstract Two‐photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two‐photon absorption and singlet‐oxygen generation. Reported here are two new diketopyrrolopyrrole‐porphyrin conjugates as robust absorbing dyes high cross‐sections within window. Furthermore, for first time generation efficiency diketopyrrolopyrrole‐containing systems investigated. A preliminary study on cell culture showed induced phototoxicity.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRigid Rod-Like Dinuclear Ru(II)/Os(II) Terpyridine-Type Complexes. Electrochemical Behavior, Absorption Spectra, Luminescence Properties, and Electronic Energy Transfer through Phenylene BridgesFrancesco Barigelletti, Lucia Flamigni, Vincenzo Balzani, Jean-Paul Collin, Jean-Pierre Sauvage, Angelique Sour, Edwin C. Constable, Alexander M. W. Cargill ThompsonCite this: J. Am. Chem. Soc. 1994, 116, 17, 7692–7699Publication Date (Print):August 1,...

Twenty years ago, researchers considered the synthesis of simple rotaxanes a challenging task, but with rapid development this field, chemists now view these interlocking molecules as accessible synthetic targets. In major advance for have developed transition metals or organic templating structures, making it easier to construct molecular systems. addition, found ways introduce new functional groups, which given compounds properties. Today can also multirotaxanes consisting several...

Good things come in small packages: For its moderate molecular weight, the metallostar complex [Fe{Gd2L(H2O)4}3]4− (see picture; L is a bipyridine–poly(aminocarboxylate) derivative) displays exceptionally high proton relaxivity, which explained terms of rigid supramolecular structure, two inner-sphere water molecules with near-optimal exchange rate, and six efficiently relaxing GdIII centers confined to space. The 2003 Nobel Prize medicine was awarded for discoveries concerning magnetic...

For the structurally rigid homometallic dinuclear complexes (ttp)Ru(tpy-tpy)Ru(ttp)4+ and (ttp)Ru(tpy-ph-tpy)Ru(ttp)4+, we have obtained ground-state absorption spectra transient-absorption difference at room temperature luminescence lifetimes in interval from to matrix (90 K); solvent was acetonitrile or butyronitrile (tpy is 2,2':6',2''-terpyridine, ttp 4'-p-tolyl-2,2':6',2''-tpy, ph 1,4-phenylene). The gathered spectroscopic data indicate that after of visible light, formation luminescent...

Dinuclear ruthenium(II) complexes have been prepared which contain back-to-back bis-terpyridine ligands of various lengths (Ru ⋯ Ru distances between 7 and 20 Å) as bridges; significant electronic coupling is observed in mixed-valence states, even for the system with longest separation.

The convergent synthesis and characterization of a potential theranostic agent, [DPP-ZnP-GdDOTA](-), which combines diketopyrrolopyrrole-porphyrin component DPP-ZnP as two-photon photosensitizer for photodynamic therapy (PDT) with gadolinium(III) DOTA complex magnetic resonance imaging probe, is presented. [DPP-ZnP-GdDOTA](-) has remarkably high longitudinal water proton relaxivity (19.94 mm(-1) s(-1) at 20 MHz 25 °C) monohydrated molecular system this size. Nuclear Magnetic Relaxation...

Abstract The EPTPA 5− chelate, which ensures fast water exchange in Gd III complexes, has been coupled to three different generations (5, 7, and 9) of polyamidoamine (PAMAM) dendrimers through benzylthiourea linkages (H 5 EPTPA=ethylenepropylenetriamine‐ N , N′ N′′ ‐pentaacetic acid). proton relaxivities measured at pH 7.4 for the dendrimer complexes G5‐(GdEPTPA) 111 G7‐(GdEPTPA) 253 G9‐(GdEPTPA) 1157 decrease with increasing temperature, indicating that, first time dendrimers, slow does not...

Abstract The heterotritopic ligand [bpy(DTTA) 2 ] 8− has two diethylenediamine‐tetraacetate units for selective lanthanide( III ) coordination and one bipyridine function Fe II coordination. In aqueous solution in the presence of these metals, is capable self‐assembly to form a rigid supramolecular metallostar structure, {Fe[Gd bpy(DTTA) (H O) 4 3 } 4− . We report here physicochemical characterization dinuclear complex [Gd 2− with regard potential MRI contrast agent applications. A...

A series of binuclear Ru(II)-Rh(III) complexes general formula (ttpy)Ru-tpy-(ph)(n)-tpy-Rh(ttpy)(5+) (n = 0-2) have been synthesized, where ttpy 4'-p-tolyl-2,2':6,2"-terpyridine and tpy-(ph)(n)-tpy represents a bridging ligand two 2,2':6',2"-terpyridine units are either directly linked together 0) or connected through one 1) 2) phenyl spacers in the 4'-position. This is characterized by (i) rigid bridge structures (ii) variable metal-metal distances (11 Å for n 0, 15.5 1, 20 2). The...

A novel ligand, H12L, based on a trimethylbenzene core bearing three methylenediethylenetriamine-N,N,N″,N″-tetraacetate moieties (–CH2DTTA4−) for Gd3+ chelation has been synthesized, and its trinuclear complex [Gd3L(H2O)6]3− investigated with respect to MRI contrast agent applications. multiple-field, variable-temperature 17O NMR proton relaxivity study yielded the parameters characterizing water exchange rotational dynamics. On basis of chemical shifts, bishydration could be evidenced. The...

A molecular theranostic agent for magnetic resonance imaging (MRI) and photodynamic therapy (PDT) consisting of four [GdDTTA](-) complexes (DTTA(4-) = diethylenetriamine-N,N,N″,N″-tetraacetate) linked to a meso-tetraphenylporphyrin core, as well its yttrium(III) analogue, was synthesized. variety physicochemical methods were used characterize the gadolinium(III) conjugate 1 both an MRI contrast photosensitizer. The proton relaxivity measured in H2O at 20 MHz 25 °C, r1 43.7 mmol(-1) s(-1) per...

A molecular theranostic agent designed for photodynamic therapy (PDT) treatment in the near-infrared and imaging tissue tumors with magnetic resonance (MRI) is reported. It consists of a linear π-conjugated Zn(II) porphyrin dimer linked at each extremity to GdDOTA-type complex. This has shown very promising potential PDT applications good singlet oxygen generation DMSO high absorption (λmax = 746 nm, ε ≈ 105 M–1 cm–1). Moreover, this molecule propensity two-photon excited cross sections...

Abstract Two‐photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two‐photon absorption and singlet‐oxygen generation. Reported here are two new diketopyrrolopyrrole‐porphyrin conjugates as robust absorbing dyes high cross‐sections within window. Furthermore, for first time generation efficiency diketopyrrolopyrrole‐containing systems investigated. A preliminary study on cell culture showed induced phototoxicity.

Eu(II) complexes are potential candidates for pO(2)-responsive contrast agents in magnetic resonance imaging. In this regard, we have characterized two novel macrocyclic chelates, [Eu(II)(DOTA)(H(2)O)](2-) and [Eu(II)(TETA)](2-) (H(4)DOTA=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, H(4)TETA=1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid) terms of redox thermodynamic complex stability, proton relaxivity, water exchange, rotation electron spin relaxation....

We have synthesized three novel binuclear heterometallic compounds where two M(tterpy)22+[tterpy = 4′-(p-tolyl)-2,2′ : 6′,2″-terpyridine] building blocks are either directly linked or connected by phenyl spacers in a rigid rod-like structure and we investigated their luminescence properties the electronic energy transfer process through spacers.

In the objective of optimizing water exchange rate on stable, nine-coordinate, monohydrated GdIII poly(amino carboxylate) complexes, we have prepared monopropionate derivatives DOTA4− (DO3A-Nprop4−) and DTPA5− (DTTA-Nprop5−). A novel ligand, EPTPA-BAA3−, bisamylamide derivative ethylenepropylenetriamine-pentaacetate (EPTPA5−) was also synthesized. variable temperature 17O NMR study has been performed their which, for [Gd(DTTA-Nprop)(H2O)]2− [Gd(EPTPA-BAA)(H2O)] combined with multiple field...

Ru-based metallostars Na4{Ru[Ln2bpy-DTTA2(H2O)4]3} (Ln = Y, Gd, and Eu) have been self-assembled in aqueous solution their relaxivity optical properties unravelled. The synthesis the purification of new, highly stable heptametallic entities optimized for diamagnetic Y3+ complex followed by 1H NMR. europium(III) ruthenium-based metallostar {Ru[Eu2bpy-DTTA2(H2O)4]3}4− displays sensitized 5D0→7FJ luminescence upon excitation tris(2,2′-bipyridyl)ruthenium(II) unit ultraviolet around 293 nm, as...

Diketopyrrolopyrrole–porphyrin conjugates show remarkable NIR emission properties, high two-photon absorption cross-sections and significant singlet oxygen production efficiency.

With the aim of developing new molecular theranostic agents, a π-extended Zn(II) porphyrin as photosensitizer for photodynamic therapy (PDT) linked to two GdDOTA-type complexes magnetic resonance imaging (MRI) detection was synthesized. The relaxivity studies revealed much higher value per Gd ion this medium sized molecule (19.32 mM–1 s–1 at 20 MHz and 298 K) compared clinical contrast agents—a which strongly increases in presence bovine serum albumin, reaching 25.22 s–1. Moreover,...