A5052779766- Analytical Chemistry and Chromatography
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- HIV/AIDS drug development and treatment
- Crystallization and Solubility Studies
- Drug Transport and Resistance Mechanisms
- Spectroscopy and Quantum Chemical Studies
- HIV Research and Treatment
- Cancer therapeutics and mechanisms
- Protein purification and stability
- DNA and Nucleic Acid Chemistry
- Biochemical and Molecular Research
- Advancements in Transdermal Drug Delivery
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS Research and Interventions
- Protein Interaction Studies and Fluorescence Analysis
- Chemical and Physical Properties in Aqueous Solutions
- Dermatology and Skin Diseases
- Material Dynamics and Properties
- Phase Equilibria and Thermodynamics
- Computational Drug Discovery Methods
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
East Carolina University
2025
University of Maryland, Baltimore
2025
Markey Cancer Center
2019
University of Kentucky
2010-2019
University of Wisconsin–Madison
2006-2013
University of New Hampshire
2001-2012
University of California, San Diego
2007
Pfizer (United States)
2004
University of Utah
1993-2003
La Roche College
1992
Dynamic dialysis is one of the most common methods for determination release kinetics from nanoparticle drug delivery systems. Drug appearance in "sink" receiver compartment a consequence nanoparticles into chamber followed by diffusion across membrane. This dual barrier nature inherent method complicates data interpretation and may lead to incorrect conclusions regarding half-lives. Although need consider properties membrane has long been recognized, there insufficient quantitative...
Hydrogen bonding interactions in amorphous indomethacin and solid dispersions of with poly(vinylpyrrolidone), or PVP, poly(vinylpyrrolidone-co-vinyl acetate), PVP/VA, were investigated quantitatively using solid-state NMR spectroscopy. Indomethacin that was (13)C isotopically labeled at the carboxylic acid carbon used to selectively analyze carbonyl region spectrum. Deconvolution peak revealed 59% molecules hydrogen bonded through cyclic dimers, 15% disordered chains, 19% amide interactions,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModification and Evaluation of the Potato Disc Assay Antitumor Screening Euphorbiaceae SeedsN. R. Ferrigni, J. E. Putnam, B. Anderson, L. Jacobsen, D. Nichols, S. Moore, McLaughlin, G. Powell, C. Smith Jr.Cite this: Nat. Prod. 1982, 45, 6, 679–686Publication Date (Print):November 1, 1982Publication History Published online1 July 2004Published inissue 1 November...
Dickeya dadantii is a plant-pathogenic enterobacterium responsible for the soft rot disease of many plants economic importance. We present here sequence strain 3937, widely used as model system research on molecular biology and pathogenicity this group bacteria.
Age-associated skeletal muscle mass loss curtails quality of life and may contribute to defects in metabolic homeostasis older persons. The onset sarcopenia occurs middle age rhesus macaques although the trigger has yet be identified. Here, we show that a shift metabolism advance vastus lateralis. Multiphoton laser-scanning microscopy detects kinetics photon emission from autofluorescent cofactors NADH FAD. Lifetime both fluorophores is shortened at mid-age, this observed free bound...
<div class="section abstract"><div class="htmlview paragraph">Decarbonized or low carbon fuels, such as hydrogen/methane blends, can be used in internal combustion engines to support ambitious greenhouse gas (GHG) emission reduction goals worldwide, including achieving neutrality by 2045. However, the volumetric concentration of H<sub>2</sub> these fuel blends surpasses 30%, in-cylinder flame propagation and rates increase significantly, causing an unacceptable...
The CCR4-NOT transcriptional regulatory complex affects transcription both positively and negatively consists of the following two complexes: a core 1 × 106dalton (1 MDa) consisting CCR4, CAF1, five NOT proteins larger, less defined 1.9-MDa complex. We report here identification new factors that associate with as follows: CAF4, WD40-containing protein, CAF16, putative ABC ATPase. Whereas neither CAF4 nor CAF16 was part complex, appeared to be present in also displayed physical interactions...
In view of the increasing use microdialysis for monitoring drug uptake into brain, consequences tissue/blood-brain barrier (BBB) damage that occurs on probe insertion extent and rate solute need to be more carefully examined. this study, both a classic method were used compare apparent brain two polar permeants, [3H]sucrose [14C]urea. The blood-to-brain transfer constants these compounds differ significantly, with value urea exceeding sucrose by factor approximately 20 when compared...
Molecular dynamics (MD) simulations have been conducted using an assembly consisting of 105 indomethacin (IMC) molecules and 12 water to investigate the underlying dynamic (e.g., rotational translational diffusivities conformation relaxation rates) structural properties conformation, hydrogen-bonding distributions, interactions with IMC) amorphous IMC. These may be important in predicting physical stability this metastable material. The IMC model was constructed X-ray diffraction data...