A5101844308- Synthesis and biological activity
- Click Chemistry and Applications
- Beetle Biology and Toxicology Studies
- Synthesis and Biological Evaluation
- Phytochemical Studies and Bioactivities
- bioluminescence and chemiluminescence research
- Synthesis of β-Lactam Compounds
- Antifungal resistance and susceptibility
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
- Steroid Chemistry and Biochemistry
- Gut microbiota and health
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial Peptides and Activities
- Catalytic C–H Functionalization Methods
- Antimicrobial Resistance in Staphylococcus
- Synthesis and Biological Activity
Arkansas State University
2021-2025
Arkansas Biosciences Institute
2021
A number of novel pyrazole derivatives have been synthesized, and several these compounds are potent antibacterial agents with minimum inhibitory concentrations as low 0.5 μg/mL. Human cell lines were tolerant to lead compounds, they showed negligible hemolytic effects at high concentrations. These bactericidal very effective against bacterial growth in both planktonic biofilm contexts. Various techniques applied show the inhibition eradication preformed biofilms by compounds. Potent more...
Design and synthesis of N-(trifluoromethyl)phenyl substituted pyrazole derivatives their potency as antimicrobial agents are described. Several these novel compounds effective growth inhibitors antibiotic-resistant Gram-positive bacteria prevent the development biofilms by methicillin-resistant Staphylococcus aureus (MRSA) Enterococcus faecalis. These eradicated preformed effectively were found to be more than control antibiotic vancomycin. Potent showed low toxicity cultured human embryonic...
An efficient synthesis of 3-amino-2-formyl-functionalized benzothiophenes by a domino reaction protocol and their use to synthesize library novel scaffolds have been reported. Reactions ketones 1,3-diones with these amino aldehyde derivatives formed series benzothieno[3,2-
In an effort to synthesize a library of bioactive molecules, we present efficient synthesis fused-thiazole derivatives natural products and approved drugs by using environmentally usable solvent, acetic acid, without any external reagent.
Thiazole derivatives are known for a wide range of therapeutic properties. Bisnoralcohol is an inexpensive natural product obtained by the biodegradation sterols. This article describes efficient synthesis library thiazole-fused bisnoralcohol derivatives. These novel compounds have been studied their antineoplastic and antibacterial properties, which led to discovery hit with potential. The compound noncytotoxic nonhemolytic against cancer cell lines sheep red blood cells, respectively....
Enterococci and methicillin-resistant S. aureus (MRSA) are among the menacing bacterial pathogens. Novel antibiotics urgently needed to tackle these antibiotic-resistant infections. This article reports design, synthesis, antimicrobial studies of 30 novel pyrazole derivatives. Most synthesized compounds potent growth inhibitors planktonic Gram-positive bacteria with minimum inhibitory concertation (MIC) values as low 0.25 µg/mL. Further led discovery several lead compounds, which...
Abstract Diosgenin, a hydrolyzed product of phytosteroid saponin, has widely been studied for its medicinal properties. In an effort to find bioactive molecules, 25 novel thiazole‐fused diosgenin molecules have synthesized by efficient reaction protocol. The chemistry involves the Oppenauer oxidation followed double bond isomerization in one‐pot reaction, epoxidation, and urea derivatives with epoxyketone synthesize target compounds. These chimeric compounds were tested their potential...
Several fused-thiazole derivatives have been studied for antimelanoma properties. Lead compounds are effective tumor growth inhibitors in mice, which potent β- and γ-actin cytoskeleton with a probable mechanism of β-PARVIN inhibition.