A5047942918- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Child Nutrition and Water Access
- Child Nutrition and Feeding Issues
- Neonatal Respiratory Health Research
- Autophagy in Disease and Therapy
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Sirtuins and Resveratrol in Medicine
- Diet and metabolism studies
- Reproductive System and Pregnancy
- Agriculture Sustainability and Environmental Impact
- Maternal and fetal healthcare
- Clinical Nutrition and Gastroenterology
University Medical Center Groningen
2019-2024
University of Groningen
2019-2024
Hospital for Sick Children
2017-2023
The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact processes such as SIRT1- mTORC1-mediated autophagy mitochondrial homeostasis. Using a mouse organoid model SM, we studied repercussions these dysregulations on enteropathy protective capacity maintaining activity health.SM was induced through feeding male weanling C57BL/6 mice low...
Background Children with medically complicated severe acute malnutrition (SAM) have high risk of inpatient mortality. Diarrhea, carbohydrate malabsorption, and refeeding syndrome may contribute to early mortality delayed recovery. We tested the hypothesis that a lactose-free, low-carbohydrate F75 milk would serve limit these risks, thereby reducing number days in stabilization phase. Methods findings In multicenter double-blind trial, hospitalized severely malnourished children were...
Objective Management of late fetal growth restriction (FGR) is limited to adequate monitoring and optimal timing delivery. The Disproportionate Intrauterine Growth Intervention Trial At Term (DIGITAT) trial compared induction labor with expectant management in pregnancies at (near) term complicated by suspected FGR. Findings the DIGITAT were that prolonged pregnancy for 10 days increased birthweight only 130 grams. This resulted more infants born below 2.3rd percentile labor, respectively...
Background: Placental insufficiency is an important mechanism underlying early-onset fetal growth restriction (eoFGR). Reduced placental function causes impaired metabolic and gaseous exchange. This unfavorable environment among other processes characterized by increased oxidative stress. Systemic free thiols (FT) are known for their reactive oxygen species scavenging capacity, higher plasma levels of FT associated with a better outcome in multitude ischemic inflammatory diseases. We aimed...
Early onset fetal growth restriction is a common pregnancy complication with significant risk of perinatal mortality and morbidity. The most etiology placental insufficiency, reflected by several lesions that appear restriction. Placental immune cells are involved in almost all aspects the development placenta cell imbalances have been related to complications. STRIDER trial investigated therapeutic potential sildenafil. No clinical improvements were observed, however, since sildenafil can...