A5067862525- Cervical Cancer and HPV Research
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- Chromatin Remodeling and Cancer
- Cytokine Signaling Pathways and Interactions
- Mobile Health and mHealth Applications
- Cancer Mechanisms and Therapy
- Biomarkers in Disease Mechanisms
- Health Literacy and Information Accessibility
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- BRCA gene mutations in cancer
- Colorectal and Anal Carcinomas
- Cleft Lip and Palate Research
- Plant Genetic and Mutation Studies
- Protein Degradation and Inhibitors
- Health Policy Implementation Science
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Metabolism, Diabetes, and Cancer
- Genital Health and Disease
- Radiomics and Machine Learning in Medical Imaging
- Community Health and Development
- Cancer and Skin Lesions
Charles R. Drew University of Medicine and Science
2015-2022
University of California, San Francisco
2000-2015
UCSF Helen Diller Family Comprehensive Cancer Center
2006-2011
Unity Health System
2006
Kaiser Permanente Oakland Medical Center
2000
Genomic instability is characterized by the increased rate of acquisition alterations in mammalian genome. These changes encompass a diverse set biological end points including karyotypic abnormalities, gene mutation and amplification, cellular transformation, clonal heterogeneity delayed reproductive cell death. The loss stability genome becoming accepted as one most important aspects carcinogenesis, numerous genetic associated with cancer implicate genomic contributing to neoplastic...
The human papillomavirus (HPV) is a major public health concern affecting both females and males.HPV associated with cervical, anal, head neck cancers.About 99% of all cervical cancers are related to HPV.HPV vaccines, Gardasil, Cervarix, Gardasil 9 used in the primary prevention HPV cancers.Gardasil available for use males ages 26, while Cervarix 25. was approved by FDA against additional types.Despite availability this preventative measure cancer, rate vaccination United States remains...
Coffin-Siris syndrome is characterized by intrauterine growth retardation, mental deficiency, coarse face, hypoplastic fifth fingers and nails, hirsutism, initial difficulties with feeding. The etiology of this unknown. We report on an 11-year-old girl a de novo, apparently balanced reciprocal translocation between chromosomes 7 22 [t(7;22)(q32;q11.2)]. 7q breakpoint in our patient very similar to the reported previous case [McPherson et al., 1997] t(1;7)(q21.3;q34). Together, these patients...
ContextMuscle aches, numbness in the feet/toes (neuropathy), and fatigue are often reported concurrently among symptoms most frequently by individuals with HIV/AIDS, whether or not they taking antiretroviral therapy (ART).ObjectivesThis study used a longitudinal analytical methodology to analyze these together determine symptom clusters maintained over time there is temporal relationship between reports of neuropathic pain muscle aches.MethodsThis was secondary analysis subset data from...
ABSTRACT Objective: The purpose of this study was to understand the processes and interactions that African American tobacco control organizations use engage communities in efforts. Design Sample: used grounded theory methods interpret participant's perspectives on control. sample consisted program directors from throughout United States. Measures: Data collection involved 1 interview per participant using a semistructured at location selected by participant. Each lasted approximately 30–90...
Abstract Human Papillomavirus (HPV) high-risk types 16 and 18 are directly associated with approximately 90% incidence of invasive cervical carcinoma. Epithelial cells infected HPV become transformed acquire genomic instability. As a result this transformation, E6 E7 oncogenes perpetually expressed. degrades the tumor suppressor p53; inhibits pRB, leading to disproportionate target cell growth proliferation. While there have been studies exploring instability induced by oncoproteins E6/E7,...
Abstract The association of human papillomavirus (HPV) with cervical cancer, head and neck cancer is well established, but the involvement HPV E6/E7 oncoproteins in breast more contentious. Previous studies suggest that high risk inactivate two tumor suppressor proteins p53 pRb signaling increase cell proliferation. There cumulative evidence 16 may have causal roles some cancers. Moreover, identified DNA tissue specimens. Nevertheless, route transmission cells has not been determined,...
Abstract Persistent infections involving high-risk types 16 and 18 of Human Papillomavirus (HPV) have been established as the etiological agent cervical cancer. Recent data indicate that several polymorphisms key regulators from DNA damage repair pathways are associated with cancer development susceptibility. The long arm chromosome 11 has received much attention a high frequency epigenetic deletions various sites, observed in HPV-long term infection lead to cancer, indicating presence...
Abstract Human papillomavirus (HPV), high-risk type 18, is directly associated with approximately 98% incidence of invasive cervical cancer. Epithelial cells infected HPV-18 become transformed and exhibit overexpression telomerase activity chromosomal instability. As a result this transformation, E6 E7 oncoproteins are perpetually expressed: degrades the tumor suppressor p53; inhibits pRB, leading to uncontrollable growth extension telomere length. While few studies explored instability...
Abstract Human Papillomavirus (HPV), a non-enveloped epitheliotropic double stranded DNA virus, is an etiological agent of oral cancer. Oral cancer related to the persistent infection by high-risk HPV type 16, E6/E7 oncoproteins. The oncoproteins significantly contribute carcinogenic genetic instability effect through degradation two gatekeeper proteins, p53 and pRB, respectively. ATM gene, also known as protein plays central role in complex processes that repair strand breaks. gene located...
Malignant progression of high-risk Papillomavirus (HPV), associated lesions is a slow and inefficient process. HPV non-enveloped epitheliotropic double stranded DNA virus, an etiological agent oral cancer. Oral cancer related to the persistent infection by type 16, E6/E7 oncoproteins. The complex significantly contribute carcinogenic genetic instability effect through degradation two gatekeeper proteins, p53 pRB, respectively. This process with viral genome integration into host cellular...
Abstract Malignant progression of high-risk Papillomavirus (HPV), associated lesions is a slow and inefficient process. HPV non-enveloped epitheliotropic double stranded DNA virus, an etiological agent oral cancer. Oral cancer related to the persistent infection by type 16, E6/E7 oncoproteins. The complex significantly contribute carcinogenic genetic instability effect through degradation two gatekeeper proteins, p53 pRB, respectively. This process with viral genome integration into host...
Human papillomavirus16 (HPV) E6/E7 oncoproteins are associated with increased chromosomal instability through Robertsonian aberrations. translocations common constitutional abnormalities in humans but considered rare occurrences cancer cells. Research is sparse surrounding viral infected cells; therefore, we examined whether HPV-E6/E7 transfection could facilitate the formation of We used spectral karyotyping (SKY) and array-comparative genomic hybridization (array-CGH) to score aberrations...
Abstract The human papillomavirus (HPV) causes 70% of oropharyngeal cancers in the United States. While molecular and cellular mechanisms stepwise progression HPV-related cervical cancer have been well studied, HPV carcinogenesis remains to be unraveled since an equivalent premalignant stage has never identified clinical tissues. In this study, a series keratinocyte cell lines derived from base tongue C3H mice were established. These cells formed varying degrees malignancy syngenetic are...
Abstract Human Papillomavirus (HPV), a non-enveloped epitheliotropic double stranded DNA virus, is an etiological agent of oral cancer, and can be cleared by host immunity. A small percentage patients that develop persistent infection with oncogenic HPV show increased risk developing HPV-associated malignancy. Head neck, oropharyngeal cancer related to the high-risk type 16, E6/E7 oncoproteins. The oncoproteins significantly contribute carcinogenic genomic instability effect through...
Abstract Coronavirus disease-19 (COVID-19). Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus resulting in severe threat to safety and public health. Genetic analyses suggest that SARS-COV-2 belongs the Betacoronavirus group Middle East (MERS-CoV). Like most viruses, some are oncogenic, genetic instability involved initiating factor for tumor progression known lead malignancy, disease sequelae. Genomic characterized by increased rate of acquisition...