Gunilla Ajne

ORCID: 0000-0003-2276-3212
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About
Contact & Profiles
Research Areas
  • Maternal and Perinatal Health Interventions
  • Pregnancy-related medical research
  • Pregnancy and preeclampsia studies
  • Blood groups and transfusion
  • Pelvic floor disorders treatments
  • Prenatal Screening and Diagnostics
  • Pregnancy and Medication Impact
  • Parvovirus B19 Infection Studies
  • Maternal and fetal healthcare
  • Assisted Reproductive Technology and Twin Pregnancy
  • Liver Diseases and Immunity
  • Nitric Oxide and Endothelin Effects
  • Neonatal Respiratory Health Research
  • Cardiovascular Issues in Pregnancy
  • Hemoglobinopathies and Related Disorders
  • Erythrocyte Function and Pathophysiology
  • Pediatric Hepatobiliary Diseases and Treatments
  • Sexual function and dysfunction studies
  • Birth, Development, and Health
  • Neonatal and fetal brain pathology
  • Liver physiology and pathology
  • Hospital Admissions and Outcomes
  • Patient Safety and Medication Errors
  • Electrolyte and hormonal disorders
  • Body Composition Measurement Techniques

Karolinska Institutet
2016-2025

Karolinska University Hospital
2016-2025

Lund University
2022

Western Sydney University
2022

Dalarna University
2022

Skåne University Hospital
2022

Health and Human Development (2HD) Research Network
2021

Integrated Cardio Metabolic Centre
2020

Canadian Blood Services
2018

IFC Research (United Kingdom)
2018

<i>Introduction:</i> We present a review of all cases intravascular transfusions in red cell alloimmunization over time span 20 years Stockholm. The aim the study is to compare our results with published from larger centers and identify areas that can be further improved. <i>Material Methods:</i> A retrospective cohort was conducted women treated intrauterine due erythrocyte immunization hospital between June 1990 2010. Primary outcome variables were fetal neonatal...

10.1159/000328683 article EN Fetal Diagnosis and Therapy 2011-01-01

Objective To estimate the incidence of RhD immunisation after implementation first trimester non-invasive fetal RHD screening to select only negative women carrying positive fetuses for routine antenatal anti-D prophylaxis (RAADP). Materials and Methods We present a population-based prospective observational cohort study with historic controls including all maternity care centres delivery hospitals in Stockholm region, Sweden. All pregnant were screened genotype pregnancy. Anti-D...

10.1371/journal.pone.0070984 article EN cc-by PLoS ONE 2013-08-06

Anti-D alloimmunization is the most common cause of severe hemolytic disease fetus and newborn (HDFN). The management pregnancies affected by less frequent red blood cell (RBC) antibodies poses a challenge to clinicians, perinatal outcomes are well described. This study aimed describe frequency clinically significant RBC in our pregnant population analyze risk prenatal postnatal treatment for HDFN relation national classification system guidelines.A retrospective cohort all alloimmunized...

10.1111/aogs.14261 article EN cc-by-nc-nd Acta Obstetricia Et Gynecologica Scandinavica 2021-09-02

Postnatal perineal pain is prevalent following childbirth and can impact women both physically emotionally. The aim of the study was to effect collegial midwifery assistance on medication 1 month after birth investigate associations between type tear pain, satisfaction with healing, resumption intercourse.

10.1111/aogs.14938 article EN cc-by-nc-nd Acta Obstetricia Et Gynecologica Scandinavica 2024-08-16

Background and aim: Transient elastography can detect liver fibrosis by estimation of stiffness. Results may be falsely high when blood flow to the is increased, such as during late stages pregnancy. The aim present study was longitudinally evaluate transient in healthy pregnant women.Methods: We recruited 24 women with normal singleton pregnancies a longitudinal cohort study. All underwent at gestational week 18–20, 26–28 36–38, well after minimum 8 weeks postpartum.Results: Mean age...

10.1080/00365521.2019.1629007 article EN Scandinavian Journal of Gastroenterology 2019-06-03

IntroductionMissed abortion (MA) is a type of miscarriage with multiple etiological factors that refers to fetal death failure the retained intrauterine product conception be discharged spontaneously. Currently in missed categorized according three main causes: Fetal, placental, and maternal factors. The aim current study was contribute increase knowledge clinical practice late first second trimester MA (Gestational age: week 11 + 0 – 20 6).Material methodsThis retrospective case series...

10.1016/j.ejogrb.2024.02.054 article EN cc-by European Journal of Obstetrics & Gynecology and Reproductive Biology 2024-03-01

Objective To investigate the traction force employed during vacuum extractions. Design Observational cross‐sectional study. Setting Obstetric Department, Karolinska University Hospital, Sweden, and Swedish National Congress of Obstetrics Gynaecology, 2013. Population Two hundred women with extraction at term 130 obstetricians participating in a simulated setting. Methods In normal clinical setting, we used specially adapted device to measure record undertake extraction. subsequent part...

10.1111/1471-0528.13222 article EN BJOG An International Journal of Obstetrics & Gynaecology 2015-01-05

Objective: Enhanced production of endothelin‐1, due to endothelial cell dysfunction has been considered be the cause increased plasma levels endothelin‐1 in preeclampsia. The present study was aimed at analyzing endothelin‐converting‐enzyme activity, (which reflect rate (ET‐1) from big (big ET‐1)), and concentrations women with preeclampsia compared normal pregnant women. Moreover, we analyzed these substances longitudinally throughout pregnancy. Study design: Twenty‐nine healthy were...

10.1081/prg-120024025 article EN Hypertension in Pregnancy 2003-01-01

Perineal tears are common after childbirth and, if not surgically repaired, they may result in a deficient perineum that can cause symptoms of pelvic floor dysfunction. reconstruction aims to restore the perineal body and increase support floor. The objective present study was estimate symptom reduction patients with vaginal delivery compare outcomes between participants or without concomitant levator ani muscle deficiency.Participants presenting at Karolinska Pelvic Floor Center least 1...

10.1111/aogs.14666 article EN cc-by-nc-nd Acta Obstetricia Et Gynecologica Scandinavica 2023-08-18

The decrease in pH monochorionic (MC) second twin may exceed that of dichorionic (DC) during vaginal delivery. aim this study was to investigate the effect chorionicity on umbilical artery relation increased twin-to-twin delivery time interval (DTI) from 30 weeks gestation. A hospital based cohort all deliveries after completed gestation with first delivered vaginally between 2007 and 2012 four units Stockholm county conducted. changes MC twins compared DC DTI studied using linear...

10.1080/01443615.2018.1514490 article EN cc-by-nc-nd Journal of Obstetrics and Gynaecology 2018-11-10

To enable early prediction of strong traction force vacuum extraction.Observational cohort.Karolinska University Hospital delivery ward, tertiary unit.Term mid and low metal cup extraction deliveries June 2012-February 2015, n = 277.Traction forces during were collected prospectively using an intelligent handle. Levels analysed pairwise by subjective category versus non-strong extraction, in order to define objective predictive value for extraction.A logistic regression model based on the...

10.1371/journal.pone.0171938 article EN cc-by PLoS ONE 2017-03-03

Severe perineal trauma sustained during childbirth is a serious complication since it can lead to both short- and long-term consequences for women. Some of the methods used prevent injuries have been evaluated in clinical trials, but there are still gaps evidence. A new practice has introduced, adopted by more than half maternity wards Sweden with aim reducing severe trauma. This procedure involves two midwives assisting woman second stage labour.In this multicentre randomised controlled...

10.1186/s13063-020-04837-7 article EN cc-by Trials 2020-11-23

Since it is difficult to identify women at increased risk of fetal brachial plexus birth palsy (BPBP) during labor and delivery, we aimed construct validate a score.A retrospective case-control study was undertaken in 2001 2006 an urban context Malmö, Sweden. A score constructed for all who had received routine municipal maternal health care Skåne University Hospital (n = 10 459). The model validated among pregnant with BPBP controls Sweden between 2007.The likelihood as the rose: 3.1%...

10.3109/14767058.2013.809415 article EN The Journal of Maternal-Fetal & Neonatal Medicine 2013-05-30

Objective To evaluate long-term neurodevelopment in children born after low-or mid-station vacuum-assisted delivery (VAD) compared with delivered by second-stage caesarean (SSCD) or spontaneous vaginal (SVD). Design Cross-sectional cohort study. Setting Two wards, Karolinska University Hospital, Sweden. Patients 253 low-station VAD, 247 an SVD, and 86 via SSCD accepted to participate. Interventions The Five-to-Fifteen questionnaire was used as a validated screening method for...

10.1136/bmjpo-2023-002048 article EN cc-by-nc BMJ Paediatrics Open 2023-10-01

Abstract Hemolytic disease of the fetus and newborn (HDFN) owing to anti-U has rarely been reported. U is part MNS system. M N glycoproteins are located on glycophorin A (GPA); S s antigens B (GPB). Individuals who lack GPB S– s– also U. The U– phenotype occurs almost exclusively in African population a very low frequency (0.25%). Anti-U immunoglobulin G class can cause hemolytic transfusion reaction HDFN. In this report we present use noninvasive method detect anemia subsequent intrauterine...

10.21307/immunohematology-2019-124 article EN Immunohematology 2013-01-01

Routine antenatal anti-D prophylaxis (RAADP) to RhD-negative women is most often administered in gestational age (GA) 28-30 weeks with the next dose postpartum. The aim of this study was analyse proportion where RAADP not detectable at term and a pilot investigate whether GA 28 38 results levels term, post-term post-delivery.In retrospective analysis, 4280 carrying an RHD positive fetus were included negative antibody screen delivery determined. In second part, 39 pregnancies prospectively,...

10.1111/vox.13092 article EN Vox Sanguinis 2021-03-27

The optimal strategy to monitor RhD-immunized pregnancies is not evident. Whether a quantitative analysis of anti-D antibodies adds valuable information titre unclear. aim this study was evaluate the relevance quantification in routine monitoring pregnancies.In retrospective study, 64 consecutive 61 immunized women with ≥128 at any time during pregnancy were included. According routine, ≥128, performed by flow cytometry and peak systolic velocity middle cerebral artery measured ultrasound....

10.1111/vox.12716 article EN Vox Sanguinis 2018-10-11
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