A5060113453- HIV Research and Treatment
- Blood donation and transfusion practices
- HIV/AIDS drug development and treatment
- Blood groups and transfusion
- Hepatitis B Virus Studies
- Hepatitis C virus research
- T-cell and Retrovirus Studies
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Blood transfusion and management
- Parvovirus B19 Infection Studies
- Pharmaceutical studies and practices
- Platelet Disorders and Treatments
- Viral Infections and Vectors
- Hemoglobinopathies and Related Disorders
- Immunodeficiency and Autoimmune Disorders
- Hemophilia Treatment and Research
- HIV-related health complications and treatments
- Healthcare Policy and Management
- Animal Disease Management and Epidemiology
- Respiratory and Cough-Related Research
- HIV, Drug Use, Sexual Risk
- Viral-associated cancers and disorders
- Cardiac, Anesthesia and Surgical Outcomes
Dutch Blood Transfusion Society
2024
Association of Pediatric Program Directors
2024
United States Food and Drug Administration
2009-2020
Center for Biologics Evaluation and Research
2009-2020
Food and Drug Administration
1985-2017
Washington University in St. Louis
2007-2013
American Red Cross
2009-2012
Health Canada
2012
New York Blood Center
2012
Canadian Blood Services
2012
Herpesvirus infections were studied in persons with or at risk for the acquired immune deficiency syndrome (AIDS). The diagnosed as follows: patients AIDS, cytomegalovirus (CMV) 34 of 34, Epstein-Barr virus (EBV) 33 herpes simplex viruses (HSV) eight and varicella zoster four 34; chronic lymphadenopathy syndrome, CMV nine EBV nine; healthy homosexual men, five 13 seven eight. Cytomegalovirus frequently related to disease death. are frequent causes serious diseases AIDS. prevalence AIDS may...
A study was designed to estimate relative analytic sensitivity and window-period (WP) closure project incremental yield of newer HBsAg tests, pooled-sample NAT, single-sample compared currently licensed tests.HBV DNA test results for 23 HBV seroconversion (SC) panels were first analyzed construct a model primary viremia. One-hundred representative samples then selected from 10 coded with 28 analytical controls. All 128 tested by seven tests four three NAT assay formats. Results obtain...
We have previously isolated a human gene from an endothelial cell cDNA library encoding putative tyrosine kinase; we designated this the fms-like (FLG). To analyze product(s) of FLG, generated rabbit polyclonal antibodies directed against synthetic peptide FLG and used it to immunoprecipitate biosynthetically labeled protein variety lines. These specifically recognized glycoprotein(s) 100, 120, 135 kDa with cores 90 110 kDa. Acidic fibroblast growth factor (aFGF) stimulated kinase activity...
Abstract: Because of concern about the safety immune globulins prepared for injection, we studied effects ethanol fractionation human plasma on lymphotropic virus, type III, (HTLV‐III) by spiking products various stops with HTLV‐III. Tests inactivation and removal indicated that ratio residual live virus in fractions/live starting was 1 × 10 ‐15 precipitate II from which globulin injection is manufactured. The results are reassuring regarding potential globulin.
This document provides the perspective as of April 2020 Working Party on Global Blood Safety International Society Transfusion use COVID-19 convalescent plasma an experimental treatment for COVID-19. The addresses following important factors to have in mind when considering this treatment: (A) eligibility criteria patients donate whole blood or plasma; (B) pre-screening and pre-donation testing donors; (C) collection (D) post-donation (E) recommendations transfusion. Intentional should be...
Abstract Monocytes are major targets of HIV infection in patients with AIDS. In vitro monocytes is associated increased expression beta 2 integrins, which increases both monocyte aggregation and monocyte/endothelial adhesion as well metalloproteinase (MMP-9) expression. Treatment primary soluble HIV-Tat protein mimicked many the properties monocytes. Tat treatment up-regulated was formation large aggregates to endothelial monolayers. their untreated TNF-alpha-treated monolayers, inhibited by...
We performed a multicenter study in 1989 to determine whether screening whole-blood donors for human immunodeficiency virus type 1 (HIV-1) p24 antigen would improve transfusion safety by identifying carriers of the who are seronegative HIV-1 antibody.
BACKGROUND. Multiple issues play a role in the effective control of childhood asthma. OBJECTIVE. To identify factors related to level asthma children receiving care from community pediatricians. PATIENTS AND METHODS. Data for 362 participating an intervention study reduce morbidity were collected by telephone-administered questionnaire. Level (well controlled, partially or poorly controlled) was derived measures recent impairment (symptoms, activity limitations, albuterol use) and number...
BACKGROUND: Thrombotic events (TEs) are rare but often serious adverse that could occur after administration of immune globulin (IG) products. Our study objective was to assess occurrence recorded TEs different US‐licensed IG products and investigate potential risk factors using a large administrative database. STUDY DESIGN AND METHODS: This is retrospective claims‐based cohort individuals exposed from January 1, 2008, through September 30, 2010, HealthCore's Integrated Research Database,...
Transfusion-transmitted infections have been documented for several arboviruses, including West Nile and dengue viruses (1). Zika virus, a flavivirus transmitted primarily by Aedes aegypti mosquitoes that has identified as cause of congenital microcephaly other serious brain defects (2), became recognized potential threat to blood safety after reports from 2013-2014 outbreak in French Polynesia. Blood concerns were based on very high infection incidence the population at large during...
Current methods of paying blood banks for products are forcing a substantial number suppliers to operate at loss. Changes in the system may be required ensure safety and adequacy supply products.
Monocytes are susceptible to HIV infection and activation by a regulatory gene product of the genome, HIV-Tat. Recently, we have demonstrated that treatment with HIV-Tat up-regulates monocyte adhesion endothelium increases metalloproteinase production. in present study, examined ability protein alter migratory invasive behavior monocytes. pretreated for 24 h 10 ng/ml exhibited enhanced compared untreated monocytes chemotaxis assays, both absence chemoattractant as well response FMLP....
Abstract Treatment of primary monocytes with soluble HIV-Tat protein is associated increased monocyte metalloproteinase-9 (MMP-9) expression and enhanced beta 2 integrin that increases monocyte/endothelial adhesion. These alterations require greater than 12 h treatment, suggesting the involvement intermediate factors. Thus, we have examined role cytokines in HIV-Tat-induced alteration function. rapidly up-regulated production IL-1 beta, IL-6, IL-8, TNF-alpha, but not IL-3,...
Infections of humans with intraerythrocytic parasites the genus Babesia can be locally prevalent in diverse regions United States. Transfusion blood and products collected from donors infected may result a serious illness that fatal. In September 2008, Food Drug Administration organized public workshop to discuss various aspects transfusion-transmitted babesiosis States including possible strategies identify defer who have been Babesia. Discussions were also held on biology, pathogenesis,...
Abstract: Infectivity of human T‐cell lymphotropic virus, Type III (HTLV‐III) was inactivated by heat more rapidly if in liquid medium than lyophilized and at 60° 56°C. When HTLV‐III added to factor VIII suspension, then heated 60°C for 2 hours or longer there elimination 1 × 10 6 vitro infectious units (IVIU) virus. Much the viral inactivation appeared result from lyophilization. The application water‐saturated chloroform material containing virus also resulted infectivity. efficiently...
This study evaluates the neurologic profiles of infants with deformational plagiocephaly. Forty-nine plagiocephaly between ages 4 and 13 months (mean age, 8.1 months) are evaluated, along 50 age-matched control subjects months). A modified version Hammersmith infant assessment was performed on each infant. caregiver completed a questionnaire regarding infant's prematurity, development, health to date. Results analyzed using t test. There is statistically significant difference in overall...
Bacterial contamination of platelet concentrates (PCs) still remains a significant problem in transfusion with potential important clinical consequences, including death. The International Society Blood Transfusion Working Party on Transfusion-Transmitted Infectious Diseases, Subgroup Bacteria, organised an international study Transfusion-Relevant Bacteria References to be used as tool for development, validation and comparison both bacterial screening pathogen reduction methods.Four...
<h3>Objective</h3> To determine whether an asthma coaching program can improve parent and child asthma-related quality of life (QOL) reduce urgent care events. <h3>Design</h3> Randomized controlled trial usual vs with coaching. Comparisons were made between groups using mixed models. <h3>Setting</h3> A Midwest city. <h3>Participants</h3> community-based sample 362 families a aged 5 to 12 years persistent asthma. <h3>Intervention</h3> 12-month structured telephone in which trained coaches...
Journal Article A novel method employing UNG to avoid carry-over contamination in RNA-PCR Get access Udaykumar, Udaykumar NLRC, Room 263, Laboratory of Molecular VirologyFDA/CBER, 1401 Rockville Pike, Rockville, MD 20852-1448, USA + Present address: The University Michigan Medical Center, MSRB 1, 4510, 1150 West Center Drive, Ann Arbor, MI 48109-0650, Search for other works by this author on: Oxford Academic PubMed Google Scholar Jay S. Epstein, Epstein Indira K. Hewlett * To whom...