A5083119527- Ocular Oncology and Treatments
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Protein Kinase Regulation and GTPase Signaling
- Bladder and Urothelial Cancer Treatments
- Cellular transport and secretion
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoplatforms for cancer theranostics
- Traumatic Ocular and Foreign Body Injuries
- Facial Trauma and Fracture Management
Sylvester Comprehensive Cancer Center
2022
University of Miami
2020-2022
National Cancer Institute
2017
Center for Cancer Research
2017
Uveal melanoma (UM) is the most common primary cancer of eye and associated with a high rate metastatic death. UM can be stratified into two main classes based on risk, class 1 having low risk 2 risk. Class have distinctive genomic, transcriptomic, histopathologic, clinical phenotype characterized by biallelic inactivation BAP1 tumor-suppressor gene, an immune-suppressive microenvironment enriched for M2-polarized macrophages, poor response to checkpoint-inhibitor immunotherapy. To identify...
Uveal melanoma (UM) is the most common primary cancer of eye and associated with a high rate metastatic death. UM can be stratified into two main classes based on risk, class 1 having low risk 2 risk. Class have distinctive genomic, transcriptomic, histopathologic, clinical phenotype characterized by biallelic inactivation BAP1 tumor suppressor gene, an immune suppressive microenvironment enriched for M2-polarized macrophages, poor response to checkpoint inhibitor immunotherapy. To identify...
Abstract Uveal melanoma (UM) is the most common primary eye cancer and has a high rate of metastasis with liver tropism. UM can be stratified according to metastatic risk into low Class 1 2 tumor. Biallelic mutational inactivation tumor suppressor BAP1 quintessential molecular feature UM, but mechanism by which loss leads poorly understood. We recently showed using single-cell RNA sequencing that microenvironment characterized large numbers inhibitory T cells macrophages. Taken together,...