A5028010624- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Oral Health Pathology and Treatment
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- Salivary Gland Disorders and Functions
- Diabetes and associated disorders
- Dental Implant Techniques and Outcomes
- Oral and gingival health research
- Education, Psychology, and Social Research
- Autoimmune Bullous Skin Diseases
- Oral and Maxillofacial Pathology
- Inflammasome and immune disorders
- Pediatric health and respiratory diseases
- Head and Neck Surgical Oncology
- Craniofacial Disorders and Treatments
- Medical and Biological Sciences
- Endodontics and Root Canal Treatments
- Dental Trauma and Treatments
- Tumors and Oncological Cases
- Inflammatory mediators and NSAID effects
- Proteoglycans and glycosaminoglycans research
- Drug-Induced Adverse Reactions
- Oral and Craniofacial Lesions
- Protease and Inhibitor Mechanisms
St. Anne's University Hospital Brno
2009-2023
Masaryk University
2003-2023
May Institute
2020
University Hospital Brno
2009-2015
Interleukin-17 contributes to the pathogenesis of type 1 diabetes mellitus (T1DM) and chronic periodontitis (CP). We analyzed IL-17A −197A/G IL-17F +7488C/T polymorphisms in T1DM CP determined their associations with IL-17 production occurrence periopathogens. Totally 154 controls, 125 T1DM, 244 patients were genotyped using 5′ nuclease<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant="normal">T</mml:mi><mml:mi...
Toll-like receptors (TLRs) belong to the pattern recognition family of signal molecules that recognize conserved microbial structures. The aim this study was analyse polymorphisms in TLR genes and their association with chronic periodontitis (CP).Two (2408G/A, i.e. Arg753Gln -16934A/T) TLR-2 three variants (-1486C/T, -1237C/T and+2848A/G) TLR-9 were studied 222 patients CP 259 unrelated controls. All detected using polymerase chain reaction-restriction fragment length polymorphism methods....
Objectives . Periodontitis is an inflammatory disease characterized by connective tissue loss and alveolar bone destruction. Interleukin-8 ( IL8 ) important in the regulation of immune response. The aim this study was to analyze four polymorphisms gene relation chronic (CP) aggressive (AgP) periodontitis. Methods A total 492 unrelated subjects were included case-control association study. Genomic DNA 278 patients with CP, 58 AgP, 156 controls genotyped, using 5′ nuclease TaqMan assay, for...
Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are platelet concentrates which have been used to improve healing regeneration of damaged tissues. The concentration growth factors greatly influences the final outcome treatment. For studying effects PRP PRF, an animal model is required. New Zealand White rabbit appears be a good candidate for features these blood derivatives. This article presents first time various preparation methods derivatives with regard - insulin-like factor,...
Objectives. The proinflammatory cytokine interleukin-6 (IL-6) is a key regulator of the host response to microbial infection and major modulator extracellular matrix catabolism bone resorption. aim this case-control study was test differences between children with without gingivitis in distribution IL-6 alleles at positions −174, −572, −597 their haplotypes. Material methods. A total 455 Caucasian children, aged 11 13 years, were enrolled study. According gingival bleeding on probing...
Different approaches to enhance healing of hard or soft tissues include the use cytokines and growth factors modify cellular behaviour.Numerous are found in autologous blood concentrates -platelet-rich plasma (PRP) platelet-rich fibrin (PRF).Enamel matrix derivative (EMD) may improve tissue via amelogenins.Bilayered collagen (CM) is used for augmentation.The aim present study was assess potential benefits PRP, PRF EMD combination with bilayered CM alone treatment oral mucosal defects...
Předmět sdělení: Ve sdělení autoři shrnují současné poznatky o vztazích mezi diabetes mellitus (DM) a onemocněním tkání dutiny ústní. V úvodu je zmíněna definice diabetu, příčiny jeho vzniku, rozdělení na základní typy popis komplikací, které DM provázejí. Uvedena jsou poslední epidemiologická data související s výskytem diabetu v České republice i ve světě. článku shrnuty projevy dutině ústní vliv tkáně parodontu (gingivitidy parodontitidy), kazivost chrupu, stav ústních sliznic (orální...
Event Abstract Back to Haplotype analysis of interleukin-8 gene polymorphisms in chronic and aggressive periodontitis Petra Borilova Linhartova1, Jan Vokurka2, Hana Poskerová2, Antonín Fassmann2 Lydie Izakovičová Hollá1, 2* 1 Faculty Medicine, Masaryk University, Brno, Department Pathophysiology, Czechia 2 Clinic Stomatology, Institutions Shared with St. Anne's Hospital, Objective: Periodontitis is an inflammatory disease characterized by connective tissue loss alveolar bone destruction....
Mucoceles are benign tumors originating from minor salivary glands of the oral cavity.They localized most frequently on lower lip or buccal mucosa.Unintentional biting, trauma, and orthodontic devices among frequent causes mucoceles.In this case report, successful treatment medium-sized mucocele with erbium laser is presented.Benefits as well potential risks surgery discussed.
Aims. Granulation tissue (GT) and specialized pro‑resolving mediators such as lipoxins resolvins are key elements in the successful resolution of periodontitis. Aspirin‑triggered even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega-3 fatty acids. The aim this study was to evaluate use GT enriched aspirin acids during surgical treatment periodontitis an experimental animal model (rabbit). Methods. In each 24 rabbits, two periodontal defects were...
Úvod a cíl studie: Genetické predispozice hrají významnou roli v etiopatogenezi jak chronické parodontitidy (CP), tak i diabetes mellitus (DM), mezi kterými existuje reciproční vztah. U obou chorob jsou za kandidátní považovány geny pro imunoregulační faktory, k nimž se řadí signální peptidy zvané cytokiny. Cílem naší studie bylo analyzovat polymorfismy ve vybraných cytokinech, konkrétně interleukin-1 (IL-1) genovém klasteru IL-6 genu, u pacientů s CP s/bez DM porovnat je zdravou populací....
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Abstract The topical application of aspirin and omega‐3 polyunsaturated fatty acids (PUFAs) may trigger the resolution inflammation by inducing biosynthesis pro‐resolvers such as lipoxins resolvins while also avoiding side effects systemic intake. This study assessed effect enhanced granulation tissue (EGT) on periodontal regeneration through local PUFAs directly to (GT) during surgery. randomized controlled experiment assesses 38 pockets in 19 patients. In every patient, two similar...
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