A5026246778- Neuroscience and Neural Engineering
- Microfluidic and Bio-sensing Technologies
- Advanced Memory and Neural Computing
- Analog and Mixed-Signal Circuit Design
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Electrochemical Analysis and Applications
- Automotive and Human Injury Biomechanics
- Mitochondrial Function and Pathology
- Transportation Safety and Impact Analysis
- Traffic and Road Safety
- Congenital heart defects research
- Fuel Cells and Related Materials
- Cardiac electrophysiology and arrhythmias
- Microbial Fuel Cells and Bioremediation
- Analytical Chemistry and Sensors
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- CCD and CMOS Imaging Sensors
Emory University
2017-2021
Georgia Institute of Technology
2017-2019
AID Atlanta
2018
This paper presents a fully integrated CMOS multimodality joint sensor/stimulator array with 1024 pixels for real-time holistic cellular characterization and drug screening. The proposed system consists of four pixel groups parallel signal-conditioning blocks. Every group contains 16 × pixels, each includes one 28 μm gold-plated electrode, 12 photodiodes, in-pixel circuits, within 58 footprint. Each supports realtime extracellular potential recording, optical detection, chargebalanced...
The paper presents a 256-pixel CMOS sensor array with in-pixel dual electrochemical and impedance detection modalities for rapid, multi-dimensional characterization of exoelectrogens. IC has 16 parallel readout channels, allowing it to perform multiple measurements high throughput enable the chip handle different samples simultaneously. contains total 2 × 256 working electrodes size 44 μm 52 μm, along reference dimensions 56 399 32 counter 106 which together facilitate resolution screening...
Cells are complex systems with concurrent multi-physical responses, and cell physiological signals often encoded spatiotemporal dynamics further coupled multiple cellular activities. However, most existing electronic sensors only single-modality cannot capture multi-parametric responses. In this paper, a 1024-pixel CMOS quad-modality interfacing array that enables profiling for drug development is presented. The features impedance characterization, optical detection, extracellular potential...
This article presents a fully integrated multi-modal CMOS cellular sensor/stimulator array chip with 21 952 pixels and 1568-pixel concurrent readouts, while each pixel can be independently reconfigured to support three sensing one stimulation modalities: potential recording, optical-point impedance sensing, bi-phasic current stimulation. The provides 3.6 mm × 1.6 active field-of-view (FoV). Each contains 8 μm gold deposited electrode, 6 photodiode, in-pixel circuits within 11 area, the...
Abstract Every heartbeat originates from a tiny tissue in the heart called sinoatrial node (SAN). The SAN harbors only ≈10 000 cardiac pacemaker cells, initiating an electrical impulse that captures entire heart, consisting of billions cardiomyocytes for each contraction. How these rare cells (the source) can overcome electrically hyperpolarizing and quiescent myocardium sink) is incompletely understood. Due to scarcity native this concept source–sink mismatch cannot be tested directly with...
Electrochemically active bacteria (exoelectrogens) are a class of microorganisms capable transferring electrons between intracellular and exocellular environments, which generate or consume electrical currents via multiple biochemical redox reactions. This unique attribute allows exoelectrogens to interface biological environments electronics for myriad hybrid "abiotic-biotic" systems applications, such as small molecule sensing, bio-computation energy harvesting [1]. However, natural...
Cardiac pacemaker cells of the sinoatrial node initiate each and every heartbeat. Compared with our understanding constituents their electrical excitation, little is known about metabolic underpinnings that drive automaticity myocytes. This lack largely owing to scarcity native cardiac Here, we take advantage induced myocytes generated by TBX18-mediated reprogramming (TBX18-iPMs) investigate comparative differences in program between working cardiomyocytes. TBX18-iPMs were more resistant...
This paper presents a fully integrated CMOS multi-modal cellular sensor/stimulator array with 21952 pixels, 1568 simultaneous parallel readout channels, 16 μm×16 μm pixel pitch for single cell resolution, and 3.6 mm×1.6 mm tissue-level field-of-view (FoV), achieving high-resolution multi-parametric potential/impedance/optical imaging holistic characterization cell-based assays. Moreover, the system reports first on-chip true 4-point impedance sensing scheme which enables precise measurements...
<div class="section abstract"><div class="htmlview paragraph">Airbag and seat belt pretensioner deployment characteristics depend on multiple factors, such as the magnitude, direction, rate of vehicle deceleration detected by crash sensors evaluated vehicle-specific algorithms. Frontal airbag deployments are likely to be commanded during frontal events with high initial typically associated change in velocity (delta-V). However, within a range moderate changes speeds, referred...
Background: The sinoatrial node (SAN) has intricate architecture, which facilitates the spontaneous action potentials generated from SAN to pace and drive neighboring myocardium. We sought create an engineered that recapitulates native SAN’s ability overcome source-sink mismatch. hypothesized spheroids consisting of induced pacemaker cells (iPM) can surrounding quiescent Methods: iPMs were created by singular expression a transcription factor, TBX18, neonatal rat ventricular myocytes as we...