A5019970978- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Vestibular and auditory disorders
- Phagocytosis and Immune Regulation
- Epilepsy research and treatment
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Neural dynamics and brain function
- Glaucoma and retinal disorders
Universidad Pablo de Olavide
2012-2024
Achucarro Basque Center for Neuroscience
2021-2023
Microglial phagocytosis of apoptotic debris prevents buildup damage neighbor neurons and inflammatory responses. Whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse preclinical monkey models stroke (macaques marmosets) by transient occlusion the medial cerebral artery (tMCAo). By analyzing recently published bulk single cell RNA sequencing databases, show that was not explained transcriptional changes. In contrast, demonstrate...
The hippocampus is crucial for acquiring and retrieving episodic contextual memories. In previous studies, the inactivation of dentate gyrus (DG) neurons by chemogenetic- optogenetic-mediated hyperpolarization led to opposing conclusions about DG's role in memory retrieval. One study used Designer Receptors Exclusively Activated Drugs (DREADD)-mediated clozapine N-oxide (CNO)-induced reported that previously formed was erased, thus concluding denate needed maintenance. other optogenetic with...
The red nucleus (RN) is a midbrain premotor center that has been suggested as being involved in the acquisition and/or performance of classically conditioned nictitating membrane/eyelid responses. We recorded rabbits activity RN and pararubral neurons during classical eyeblink conditioning using delay paradigm. Neurons were identified by their antidromic activation from contralateral facial accessory abducens nuclei synaptic ipsilateral motor cortex (MC) cerebellar interpositus (IP) nucleus....
Transcranial direct-current stimulation (tDCS) is a non-invasive brain technique consisting in the application of weak electric currents on scalp. Although previous studies have demonstrated clinical value tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps knowledge underlying physiological mechanisms. To define immediate impact as well after effects sensory processing, we first performed electrophysiological recordings primary somatosensory cortex (S1)...
Learning-related changes in strength selected hippocampal synapses have been described recently. However, information is scarce regarding the spatial-temporal sequence of synaptic weights taking place during acquisition a classical conditioning task and contribution both context (environmental details) cues (conditioned unconditioned stimuli: CS, US) to those activity-dependent changes. We recorded rabbits monosynaptic field excitatory postsynaptic potentials (fEPSPs) evoked at 6 different...
Cathodal direct current stimulation (cDCS) induces long-term depression (LTD)-like reduction of cortical excitability (DCS-LTD), which has been tested in the treatment epilepsy with modest effects. In part, this may be due to variable neuron orientation relative electric field. We tested, vivo and vitro, whether DCS-LTD occurs throughout thickness, if not, then drug-DCS pairing can enhance uniformity response cDCS antiepileptic effect.cDCS-mediated changes were measured vitro mouse motor...
The organization of fear memory involves the participation multiple brain regions. However, it is largely unknown how formed, which circuit pathways are used for "printing" engrams across regions, and role identified circuits in retrieval. With advanced genetic methods, we combinatorially blocked presynaptic output manipulated N-methyl-D-aspartate receptor (NMDAR) basolateral amygdala (BLA) medial prefrontal cortex (mPFC) before after cued conditioning. Further, tagged fear-activated neurons...
Abstract Transcranial direct-current stimulation (tDCS) is a non-invasive brain technique consisting in the application of weak electric currents on scalp. Although previous studies have demonstrated clinical value tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps knowledge underlying physiological mechanisms. To define immediate impact as well after-effects sensory processing, we first performed electrophysiological recordings primary somatosensory...
ABSTRACT Microglial phagocytosis is rapidly emerging as a therapeutic target in neurodegenerative and neurological disorders. An efficient removal of cellular debris necessary to prevent buildup damage neighbor neurons the development an inflammatory response. As brain professional phagocytes, microglia are equipped with array mechanisms that enable them recognize degrade several types cargo, including undergoing apoptotic cell death. While very competent phagocytes cells under physiological...