A5081378589- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiomics and Machine Learning in Medical Imaging
- Photoacoustic and Ultrasonic Imaging
- Neurological Disorders and Treatments
- MRI in cancer diagnosis
- Gastrointestinal motility and disorders
- Climate Change and Environmental Impact
- Tropical and Extratropical Cyclones Research
- Inflammatory Bowel Disease
- Digestive system and related health
- Cerebral Venous Sinus Thrombosis
- Hydrology and Watershed Management Studies
- Stroke Rehabilitation and Recovery
- Medical Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
- Brain Tumor Detection and Classification
- Advanced X-ray and CT Imaging
Universität Hamburg
2018-2022
University Medical Center Hamburg-Eppendorf
2018-2022
Stanford University
2020-2022
University of Nottingham Malaysia Campus
2011
Patients with acute ischemic stroke due to large vessel occlusion and favorable tissue-level collaterals (TLCs) likely have robust cortical venous outflow (VO). We hypothesized that VO predicts TLC good clinical outcomes.Multicenter retrospective cohort study of consecutive patients who underwent thrombectomy triage. Included had interpretable prethrombectomy computed tomography, tomography angiography, cerebral perfusion imaging. TLCs were measured on studies using the hypoperfusion...
Background Ischemic lesion net water uptake (NWU) at noncontrast head CT enables quantification of cerebral edema in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Purpose To assess whether favorable venous outflow (VO) profiles angiography are associated reduced NWU and good functional outcomes AIS LVO. Materials Methods This multicenter retrospective cohort study evaluated consecutive LVO who underwent thrombectomy triage between January 2013 December 2019....
Background and Purpose: Intracranial hemorrhage (ICH) remains a major complication of endovascular treatment (ET) in acute stroke. The aim this study was to identify clinical imaging predictors for ICH patients with ischemic stroke undergoing successful ET. Methods: We performed retrospective analysis large vessel occlusion the anterior circulation who underwent ET at our university medical center between 2015 2018. diagnosed on non-enhanced CT binary outcome defined: occurrence immediate...
Robust arterial collaterals are associated with successful reperfusion after thrombectomy treatment of acute ischemic stroke due to large vessel occlusion (AIS-LVO). Excellent venous outflow (VO) reflects excellent tissue perfusion and collateral status in patients AIS-LVO. The goal this study was determine whether favorable VO profiles assessed on pretreatment CT angiography (CTA) images correlate AIS-LVO.This a multicenter retrospective cohort consecutive AIS-LVO treated by thrombectomy....
Ischemic lesion Net Water Uptake (NWU) quantifies cerebral edema formation and likely correlates with the microvascular perfusion status of patients acute ischemic stroke due to large vessel occlusion (AIS-LVO). We hypothesized that favorable tissue-level collaterals (TLC) predict less NWU good functional outcomes. performed a retrospective multicenter analysis AIS-LVO who underwent thrombectomy triage. TLC were measured on studies using hypoperfusion intensity ratio (HIR; volume brain...
Robust cerebral collaterals are associated with favorable outcomes in patients acute ischemic stroke due to large vessel occlusion treated by thrombectomy. However, collateral status assessment mostly relies on single imaging biomarkers and a more comprehensive holistic approach may provide deeper insights into the biology of perfusion medical imaging. Comprehensive collateralization is defined as blood flow arteries through brain tissue draining veins. We hypothesized that analysis cascade...
Background and purpose Early neurological improvement (ENI) after thrombectomy is associated with better long-term outcomes in patients acute ischaemic stroke due to large vessel occlusion (AIS-LVO). Whether cerebral collaterals influence the likelihood of ENI poorly described. We hypothesised that favourable collateral perfusion at arterial, tissue-level venous outflow (VO) levels thrombectomy. Materials methods Multicentre retrospective study AIS-LVO treated by Tissue-level (TLC) were...
Background: In patients with acute ischemic stroke due to large vessel occlusion (AIS–LVO), development of extensive early brain edema is associated poor functional outcomes, despite timely treatment. Robust cortical venous outflow (VO) profiles correlate favorable tissue perfusion. We hypothesized that VO (VO+) a reduced progression rate (EPR) and good outcomes. Methods: Multicenter, retrospective analysis investigate AIS–LVO treated by mechanical thrombectomy between May 2013 December...
The hypoperfusion intensity ratio (HIR) is associated with collateral status and reflects the impaired microperfusion of brain tissue in patients acute ischemic stroke large vessel occlusion (AIS-LVO). As a deterioration cerebral blood flow edema, we aimed to investigate whether HIR correlated early edema progression rate (EPR) determined by net water uptake (NWU) multicenter retrospective analysis AIS-LVO anticipated for thrombectomy treatment. was automatically calculated as...
Arterial clot localization affects collateral flow to ischemic brain in patients with acute stroke due large vessel occlusion (AIS-LVO). We determined the association between locations, tissue-level collaterals (TLC), and venous outflow (VO) profiles their impact on good functional outcomes.We conducted a multicenter retrospective cohort study of consecutive AIS-LVO who underwent thrombectomy triage. Baseline computed tomographic angiography (CTA) was used localize occlusion, which...
Background Recent studies found that favorable venous outflow (VO) profiles are associated with higher reperfusion rates after mechanical thrombectomy (MT) in patients acute ischemic stroke due to large vessel occlusion (AIS-LVO). Fewer retrieval attempts and first-pass revascularization during MT lead better functional outcomes. Objective To examine the hypothesis VO assessed on baseline CT angiography (CTA) images correlate successful first attempt fewer attempts. Methods A multicenter...
Intravenous tPA (tissue-type plasminogen activator) is often administered before endovascular thrombectomy (EVT). Recent studies have questioned whether necessary given the high rates of arterial recanalization achieved by EVT, but impacts venous outflow (VO) unknown. We investigated improves VO profiles on baseline computed tomography (CT) angiography (CTA) images EVT.Retrospective multicenter cohort study patients with acute ischemic stroke due to large vessel occlusion undergoing EVT...
Early differentiation of neoplastic and non-neoplastic intracerebral hemorrhage (ICH) can be difficult in initial radiological evaluation, especially for extensive ICHs. The aim this study was to evaluate the potential a machine learning-based prediction etiology acute ICHs based on quantitative radiomic image features extracted from non-contrast-enhanced computed tomography (NECT) brain scans.
Background: Thrombus fragmentation causing distal emboli is a feared complication during mechanical thrombectomy (MT). We aimed to investigate the impact of procedural parameters and thrombus properties on incidence peripheral after MT for large vessel occlusions (LVO). Methods: performed prospective analysis patients with LVO stroke successfully treated MT, defined as score 2b, 2c, or 3 thrombolysis in cerebral infarction (TICI) scale. A follow-up MRI including high-resolution...
Abstract Purpose Use of automated perfusion software has gained importance for imaging stroke patients mechanical thrombectomy (MT). We aim to compare four packages: 1) with respect their association 3‑month functional outcome after successful reperfusion MT in comparison visual Cerebral Blood Volume - Alberta Stroke Program Early CT Score (CBV-ASPECTS) and collateral scoring 2) agreement estimation core penumbra volume. Methods This retrospective, multicenter cohort study (2015–2019)...
The adaptive immune response and IL-17A contribute to renal damage in several experimental models of injury.
Abstract Background and aim To analyze the incidence of peripheral emboli after successful mechanical thrombectomy (MT) intracranial large vessel occlusions (LVO). Methods We performed a prospective analysis patients with LVO who underwent MT received 1.5 T MRI including diffusion-weighted imaging (DWI) in standard- high-resolution as well susceptibility-weighted (SWI) on day following intervention. Reperfusion grade was assessed post-thrombectomy digital subtraction angiography (DSA) using...
Thrombus microfragmentation causing peripheral emboli (PE) during mechanical thrombectomy (MT) may modulate treatment effects, even in cases with successful reperfusion. This study aims to investigate whether intravenous alteplase is of potential benefit reducing PE after MT.
<h3>Purpose</h3> The quality of cerebral microperfusion (CM) is strongly related to vessel occlusion location and the robustness arterial intracranial collaterals (IC) in patients with acute ischemic stroke due large (AIS-LVO). venous microcirculation profile (VMP) may more accurately reflect tissue perfusion compared IC, but it unclear what extent CM affected by clot localization. We determined, if localizations predict VMP AIS-LVO patients. <h3>Materials Methods</h3> performed a...
<h3>Purpose</h3> Robust pial arterial collaterals (PAC) preserve blood flow to critically hypoperfused brain tissue in patients with acute ischemic stroke due large vessel occlusion (AIS-LVO). CT angiography (CTA) based methods of collateral assessment do not provide level perfusion information, and prior studies have shown that PAC on imaging strongly predicts outcome AIS-LVO treated by thrombectomy. Patients favorable also likely robust cortical venous drainage relative more impaired...
<h3>Purpose</h3> In the event of an acute ischemic stroke due to large vessel occlusion (AIS-LVO), patients with core infarction and malignant edema have worse outcomes. Core size growth is caused by poor cerebral blood flow impaired microvascular perfusion. Cerebral perfusion governed in-flow arterial brain tissue, but also likely outflow through veins. Venous in context AIS-LVO may better indicate overall quality tissue perfusion, as it reflects after passing tissue. We determined if...
Background and Purpose: Robust collateral blood flow in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO) has been correlated favorable outcomes. Collaterals are commonly assessed by the number of arteries present on non-invasive CT angiography (CTA) overlying brain, but transit from these through brain tissue venous drainage is not this technique. We hypothesized that a comprehensive imaging analysis cerebral cascade (CCC) would predict clinical radiological...