A5024870513- Trauma and Emergency Care Studies
- Abdominal Trauma and Injuries
- Trauma Management and Diagnosis
- Emergency and Acute Care Studies
- Pelvic and Acetabular Injuries
- Cardiac Arrest and Resuscitation
- Injury Epidemiology and Prevention
- Urologic and reproductive health conditions
- Pleural and Pulmonary Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Ultrasound in Clinical Applications
- Case Reports on Hematomas
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Hernia repair and management
- Pediatric Urology and Nephrology Studies
- Metastasis and carcinoma case studies
- Glycosylation and Glycoproteins Research
National Trauma Research Institute
2017-2024
Sultan Qaboos University Hospital
2009-2024
Monash University
2017-2024
The Alfred Hospital
2011-2024
Alfred Health
2015-2024
Deakin University
2019-2021
Post Graduate Institute of Medical Education and Research
2011-2021
Inspire Institute
2021
Boston Medical Center
2020
Boston University
2020
Abstract Background This pilot study was carried out to determine whether Helicobacter pylori can be detected in normal colon or association with colorectal neoplasia. Methods Paraffin processed colonic tissue blocks of mucosa (n = 60), and patients diagnosed as adenoma adenocarcinoma 60) were retrieved from our archive; the group included tubular 20), tubulovillous 20) villous adenomas 20). 4 μm sections stained by immunohistochemical methods using anti- antibodies (polyclonal NCL-HPp...
Background and Objectives Haemorrhage‐associated calcium loss may lead to disruption of platelet function, intrinsic extrinsic pathway‐mediated haemostasis cardiac contractility. Among shocked major trauma patients, we aimed investigate the association between admission hypocalcaemia adverse outcomes. Materials Methods Data were extracted from Alfred Trauma Registry Applications Knowledge Management Department for all adult patients presenting directly scene with a shock index ≥1 1 July 2014...
Breast cancer commonly metastasises to the brain, but little is known about changes in molecular profile of brain secondaries and impact on clinical outcomes. Patients with samples from metastases matched breast cancers were included. Immunohistochemical analysis for oestrogen receptor, progesterone p27kip1, cyclin D1, epidermal growth factor insulin like 1, 1 vascular endothelial A, transforming factor-β HER2 receptor was performed. Borderline results analysed by fluorescent situ...
We report a case of compassionate use haemoglobin-based oxygen carrier in severely injured Jehovah's Witness patient, for whom survival was considered unlikely. Severe anaemia and cardiac hypoxia were reversed after slow infusion this agent. No vasoactive side effects associated with the treatment, possibly due to infusion, patient survived.
autoimmune hepatitis (AIH) is thought to present rarely in old people. The aims of the study were (i) review individuals diagnosed clinically as having AIH presenting over or under 65 years age at Freeman Hospital, Newcastle, from 1979 1993 and (ii) compare diagnostic histological scores, treatment outcome, hence provide a useful profile disease older patients.310 with diagnosis chronic identified, medical notes 286 revealed 54 AIH. Of these, 12 (22%) > =65 presentation.at presentation, mean...
CD44 and its variant isoforms are a group of transmembrane glycoproteins which play important roles in immune recognition, lymphocyte trafficking, cell–cell cell–matrix interactions. Although is expressed by some normal human epithelial mesenchymal cells, upregulation expression has been related to the metastatic potential malignant tumours. In this study 27 hepatocellular carcinomas (HCCs), an indirect immunohistochemical method was used investigate distribution liver determine whether...
Abstract Background As an adjunct to non-operative management, splenic artery embolization (SAE) has been increasingly utilized throughout the world and is now standard of care for hemodynamically stable patients. This study aimed retrospectively assess rate salvage complications after SAE blunt trauma at a level 1 center using 2018 update AAST criteria, further sub-stratify role angiography in grade III injuries with significant hemoperitoneum. All patients between January 2009 2019 who...
Trauma to the pelvic ring and associated haemorrhage represent a management challenge for multidisciplinary trauma team. In up 10% of patients, bleeding can be result an arterial injury mortality is reported as high 89% in this cohort. We aimed assess rate after embolisation whether earlier improved mortality.
The wide-spread use of an initial 'Glasgow Coma Scale (GCS) 8 or less' to define and dichotomise 'severe' from 'mild' 'moderate' traumatic brain injury (TBI) is out-dated research heuristic that has become epidemiological convenience transfixing clinical care. Triaging based on GCS can delay the care patients who have rapidly evolving injuries. Sole reliance therefore provide a false sense security caregivers fail timely for presenting with greater than 8. Nearly 50 years after development -...
Abstract A procedure for the simultaneous extraction and purification of four calcimedins from chicken gizzard, rat liver, bovine liver is described. These proteins bind to hydrophobic resins in a calcium‐dependent manner similar calmodulin troponin C. The purified had molecular weights 67,000 (67K), 35,000 (35K), 33,000 (33K), 30,000 (30K) as determined by SDS polyacrylamide gel electrophoresis. Their ability calcium was demonstrated using Hummel‐Dreyer method. tissue concentration ranged...
BACKGROUND: Carcinoma of the prostate metastasising to penis is rare. These patients have a poor prognosis receiving various treatment modalities. CASE PRESENTATION: Two such are discussed here having received differing therapeutic regimes, pointing out necessity for standardised palliative rather than radical therapy. CONCLUSION: Management with penile metastases from carcinoma should emphasise improving quality life therapy
Inhaled nitric oxide (iNO) is commonly administered for selectively inhaled pulmonary vasodilation and prevention of oxidative injury after lung transplant (LT). epoprostenol (iEPO) has been introduced worldwide as a cost-saving alternative to iNO without high-grade evidence this indication.To investigate whether the use iEPO will lead similar rates severe/grade 3 primary graft dysfunction (PGD-3) adult LT when compared with iNO.This health system-funded, randomized, blinded (to...
Abstract Background To determine the causes of cardiac tamponade (CT), focussing especially on haemopericardium (HP), as a terminal mode death, within 430,000 rural English population. Methods Our hospital mortuary register and, all postmortem reports between 1995 and 2004 inclusive, were interrogated for patients dying CT or HP. The CT/HP selected morphological characteristics then determined. Results 14,368 postmortems performed in this period: these, 461 died CT. Three cases due to...
Irinotecan specifically targets topoisomerase I (topoI), and is used to treat various solid tumors, but only 13–32% of patients respond the therapy. Now, it understood that rapid rate topoI degradation in response irinotecan causes resistance. We have published deregulated DNA-PKcs kinase cascade ensures at core drug resistance mechanism inhibitors, including irinotecan. also identified CTD small phosphatase 1 (CTDSP1) (a nuclear phosphatase) as a primary upstream regulator inhibitors....