A5069841532- CAR-T cell therapy research
- Video Analysis and Summarization
- Immune Cell Function and Interaction
- Advanced Image and Video Retrieval Techniques
- Hematopoietic Stem Cell Transplantation
- Image Retrieval and Classification Techniques
- Multimedia Communication and Technology
- Music and Audio Processing
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Acute Myeloid Leukemia Research
- Wound Healing and Treatments
- Acute Lymphoblastic Leukemia research
- Viral Infectious Diseases and Gene Expression in Insects
- Herpesvirus Infections and Treatments
- Selenium in Biological Systems
- Neonatal Respiratory Health Research
- Chronic Lymphocytic Leukemia Research
- Biosimilars and Bioanalytical Methods
- Immune cells in cancer
- Glutathione Transferases and Polymorphisms
- Multiple Myeloma Research and Treatments
- Multimodal Machine Learning Applications
Riley Hospital for Children
2013-2025
University Hospitals Seidman Cancer Center
2018-2025
Case Western Reserve University
2014-2025
Indiana University – Purdue University Indianapolis
2013-2025
Prince Charles Hospital
2024-2025
Washington University in St. Louis
2015-2024
United States Air Force Academy
2022
Dalhousie University
2022
University of Oxford
2018-2021
Genomics (United Kingdom)
2021
Infectious diseases are important causes of morbidity and mortality in patients with cancer. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Prevention Treatment Cancer-Related Infections characterize the major pathogens to which cancer susceptible, a focus on prevention, diagnosis, treatment common opportunistic infections. This portion guidelines highlights sections antifungal antiviral prophylaxis. Antifungal prophylaxis recommendations have expanded over past few...
Rationale: The relationship between clinical phenotype of childhood primary ciliary dyskinesia (PCD) and ultrastructural defects genotype is poorly defined.Objectives: To delineate features PCD their associations with genotype.Methods: A total 118 participants younger than 19 years old were evaluated prospectively at six centers in North America using standardized procedures for diagnostic testing, spirometry, chest computed tomography, respiratory cultures, phenotyping.Measurements Main...
Organizing digital photograph collections according to events such as holiday gatherings or vacations is a common practice among photographers. To support photographers in this task, we present similarity-based methods cluster photos by time and image content. The approach general unsupervised, makes minimal assumptions regarding the structure statistics of photo collection. We several variants an automatic unsupervised algorithm partition collection photographs based either on temporal...
This study evaluated the eytotoxicity of commonly used topical agents to human dermal fibroblasts and cpidermal keratinocytes, which play a prominent role in wound healing. The effects these were assessed using two separate assays for fibroblasts—tritiated thymidine incorporation uptake vital dye (neutral red). Keratinocytes with neutral red assay. Serial dilutions each 10 produced decreases both at clinically relevant doses. Only Neosporin G.U. irrigant showed no significant difference...
We present findings regarding the state of field Algorithm Visualization (AV) based on our analysis a collection over 500 AVs. examine how AVs are distributed among topics, who created them and when, their overall quality, they disseminated. There does exist cadre good active developers. Unfortunately, we found that many low coverage is skewed toward few easier topics. This can make it hard for instructors to locate what need. no effective repositories currently available, which puts at risk...
We have recently reported that interferon gamma receptor deficient (IFNγR-/-) allogeneic donor T cells result in significantly less graft-versus-host disease (GvHD) than wild-type (WT) cells, while maintaining an anti-leukemia or graft-versus-leukemia (GvL) effect after hematopoietic stem cell transplantation (allo-HSCT). demonstrated IFNγR signaling regulates alloreactive trafficking to GvHD target organs through expression of the chemokine CXCR3 cells. Since is mediated via JAK1/JAK2, we...
Natural killer (NK) cells are an emerging cancer cellular therapy and potent mediators of antitumor immunity. Cytokine-induced memory-like (ML) NK is safe induces remissions in patients with acute myeloid leukemia (AML). However, the dynamic changes phenotype that occur after NK-cell transfer affect patient outcomes remain unclear. Here, we report comprehensive multidimensional correlates from ML cell-treated AML using mass cytometry. These data identify a unique vivo differentiated distinct...
Chimeric antigen receptor (CAR) T cell therapy is routinely used to treat patients with refractory hematologic malignancies. However, a significant proportion of experience suboptimal CAR cytotoxicity and persistence that can permit tumor escape disease relapse. Here we show prototype pro-lymphoid growth factor able enhance efficacy. We demonstrate long-acting form recombinant human interleukin-7 (IL-7) fused hybrid Fc (rhIL-7-hyFc) promotes proliferation, cells in xenogeneic mouse models,...
Selenium may affect prostate cancer risk via its plasma carrier selenoprotein P which shows dramatically reduced expression in tumors and cell lines. The (SEPP1) Ala234 single nucleotide polymorphism (SNP) allele is associated with lower men, reducing the concentration/activity of other antioxidant selenoproteins. status also modifies effect mitochondrial superoxide dismutase (SOD2) SNP Ala16Val on risk. We investigated relationship these SNPs DNA from 2,975 cases 1,896 age-matched controls...
As an emerging class of nanomaterial, nanoclusters hold great potential for biomedical applications due to their unique sizes and related properties. Herein, we prepared a (64)Cu doped gold nanocluster ((64)CuAuNC, hydrodynamic size: 4.2 ± 0.5 nm) functionalized with AMD3100 (or Plerixafor) targeted positron emission tomography (PET) imaging CXCR4, up-regulated receptor on primary tumor lung metastasis in mouse 4T1 orthotopic breast cancer model. The preparation (64)CuAuNCs-AMD3100 (4.5 0.4...
Abstract Most cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly a complicated milieu such as bone marrow where progenitor stem cells reside. Here, we demonstrate the treatment by photoactivatable drugs using radiopharmaceuticals. An orthogonal-targeting strategy and contact-facilitated nanomicelle technology enabled highly selective delivery co-localization titanocene radiolabelled...
Despite improvement in treatment options for myeloma patients, including targeted immunotherapies, multiple remains a mostly incurable malignancy. High CS1 (SLAMF7) expression on cells and limited normal makes it promising target CAR-T therapy. The protein has two extracellular domains - the distal Variable (V) domain proximal Constant 2 (C2) domain. We generated tested CS1-CAR-T targeting V of (Luc90-CS1-CAR-T) demonstrated anti-myeloma killing vitro vivo using mouse models. Since...
Abstract T-cell malignancies are associated with frequent relapse and high morbidity, which is partly due to the lack of effective or targeted treatment options. To broaden use CAR-T cells in pan malignancies, we developed an allogeneic “universal” CD2-targeting cell (UCART2), CD2 antigen deleted prevent fratricide, receptor removed GvHD. UCART2 demonstrated efficacy against T-ALL CTCL prolonged survival tumor-engrafted NSG mice vivo. evaluate impact on function, generated CD19 (UCART19)...
We present a framework for analyzing the structure of digital media streams. Though our methods work video, text, and audio, we concentrate on detecting music files. In first step, spectral data is used to construct similarity matrix calculated from inter-frame similarity.The audio can be robustly segmented by correlating kernel along diagonal matrix. Once segmented, statistics each segment are computed. second step,segments clustered based self-similarity their statistics. This reveals in...
We present a framework for summarizing digital media based on structural analysis. Though these methods are applicable to general media, we concentrate here characterizing the repetitive structure in popular music. In first step, similarity matrix is calculated from interframe spectral similarity. Segment boundaries, such as verse-chorus transitions, found by correlating kernel along diagonal of matrix. Once segmented, statistics each segment computed. second segments clustered, pairwise...