A5103120116- Glioma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Spaceflight effects on biology
- Advances in Oncology and Radiotherapy
- Immunotherapy and Immune Responses
- Meningioma and schwannoma management
- Peripheral Neuropathies and Disorders
- Brain Metastases and Treatment
- Cerebrovascular and genetic disorders
- Drug-Induced Adverse Reactions
- Space Exploration and Technology
- Chemotherapy-related skin toxicity
- Indoor Air Quality and Microbial Exposure
- Neurofibromatosis and Schwannoma Cases
- Advanced X-ray and CT Imaging
- Palliative Care and End-of-Life Issues
- Empathy and Medical Education
- Melanoma and MAPK Pathways
- Polyomavirus and related diseases
- Biomedical and Engineering Education
University of Vermont Medical Center
2016-2025
University of Vermont
2022
Institute of Neurological Sciences
2021
Memorial Sloan Kettering Cancer Center
2015-2017
Cornell University
2015
Dartmouth–Hitchcock Medical Center
2013-2014
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown. We performed a phase I clinical trial ibrutinib, first-in-class inhibitor, for patients relapsed or refractory CNS lymphoma. Clinical responses to ibrutinib occurred 10 13 (77%) PCNSL, including five complete responses. only PCNSL resistance harbored mutation within coiled-coil domain CARD11, known...
The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) accumulate metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this can be detected vivo using proton magnetic-resonance spectroscopy (MRS), but sensitivity methodology its clinical implications are unknown.We developed an MR imaging protocol to integrate 2HG-MRS into routine glioma examined performance 89 consecutive patients.Detection...
Patients with progressive or recurrent meningiomas have limited systemic therapy options. Focal adhesion kinase (FAK) inhibition has a synthetic lethal relationship
Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed examine the use of DWI T1-weighted dynamic contrast-enhanced-MR as potential discriminative tools.We retrospectively reviewed 18 patients with 36 matched glioblastoma pretreatment imaging. VOIs were drawn around tumor on contrast-enhanced T1WI FLAIR images; these images...
Epidermal growth factor receptor variant III is a common mutation in glioblastoma, found approximately 25% of tumors. may accelerate angiogenesis malignant gliomas. We correlated T1-weighted dynamic contrast-enhanced MR imaging perfusion parameters with epidermal status.Eighty-two consecutive patients glioblastoma and known status who had before surgery were evaluated. Volumes interest drawn around the entire enhancing tumor on contrast images then transferred onto coregistered maps....
Glioblastomas treated with bevacizumab may develop low-signal apparent diffusion coefficient (low-ADC) lesions, which reflect increased tumor cellularity or atypical necrosis. The purpose of this study was to examine the relationship between low-ADC lesions and overall survival (OS). We hypothesized that growing would be associated shorter OS.We retrospectively identified 52 patients for first (n = 42, 81%) later recurrence primary glioblastoma, who had 2 post-bevacizumab scans ≤90 days...
Temozolomide (TMZ) is an alkylating drug most often used in the treatment of primary brain malignancies. Herein, we report unusual cutaneous adverse reaction (ADR) associated with TMZ and characterized by temporally distinct dermal subcutaneous hypersensitivity reactions.
Demyelinating disease can acutely affect the central or peripheral nervous system in forms of acute disseminated encephalomyelitis, inflammatory demyelinating polyradiculoneuropathy, and related disorders. Rarely, demyelination simultaneously a disorder that has been described as severe combined demyelination. We describe 54-year-old woman who presented with rapidly progressive ascending paralysis areflexia abnormalities cerebrospinal fluid, electrodiagnostic studies, magnetic resonance...
We created an immersed collaborative learning curriculum in Neuro-Oncology delivered interactive retreat format for residents and evaluated its impact on skills, knowledge, specialty choice.
Choroid plexus metastases are extremely rare from all types of malignancy, with only 42 cases reported in the literature thus far. Most these originate renal cell carcinoma and present as a solitary choroid lesion; two multifocal have been to date.The authors report third case plexus, that 75-year-old man who developed three measurable lesions approximately 3.5 years after undergoing total thyroidectomy chemotherapy for papillary thyroid carcinoma. He underwent intraventricular biopsy...
LCH is a rare hematopoietic malignancy due to dendritic cell clonal proliferation, which commonly presents as sinusitis. Between 6 and 25% of cases involve the central nervous system (CNS). rarely associated with other hematologic malignancies, including AML. We describe 59-year-old patient right frontal sinus metastatic regional lymph nodes colon who presented acute meningoencephalitis was found have AML isolated CNS. The initially antibiotic-refractory recurrent sinusitis diagnosed...
<h3>Objective:</h3> N/A <h3>Background:</h3> Cerebral amyloid angiopathy (CAA) leads to deposition of amyloid-beta-peptide in leptomeninges and cerebral blood vessels. A <i>β</i>-related angiitis (ABRA) is a severe form CAA characterized by transmural inflammation and/or, granulomatous inflammation. We report two patients with advanced malignancy presenting leptomeningeal enhancement (LME) concerning for metastases, biopsy demonstrating ABRA. <h3>Design/Methods:</h3> 76-year-old man...
Abstract BACKGROUND Glioblastoma (GBM) is an aggressive neurologic malignancy with invariably poor prognosis. However, there evidence that patients GBM often have unrealistic perceptions of their Strong religious beliefs been shown to be associated limited illness understanding (IU) in advanced cancer, but IU and religiousness not investigated GBM. METHODS Patients enrolled a prospective multi-center study recurrent (Coping Glioblastoma; NCT02375841) completed surveys after clinical...
<div>Abstract<p>Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown. We performed a phase I clinical trial ibrutinib, first-in-class inhibitor, for patients relapsed or refractory CNS lymphoma. Clinical responses to ibrutinib occurred 10 13 (77%) PCNSL, including five complete responses. only PCNSL resistance harbored mutation within coiled-coil...