A5084910701- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Diabetes and associated disorders
- Advanced Control Systems Optimization
- Multiple Sclerosis Research Studies
- Glaucoma and retinal disorders
- Allergic Rhinitis and Sensitization
- Peripheral Neuropathies and Disorders
- Microscopic Colitis
- Photonic and Optical Devices
- Asthma and respiratory diseases
- Chemotherapy-related skin toxicity
- Hidradenitis Suppurativa and Treatments
- Sphingolipid Metabolism and Signaling
- Dermatology and Skin Diseases
- Corneal surgery and disorders
- Chemokine receptors and signaling
- Cerebral Venous Sinus Thrombosis
Novartis (Switzerland)
2004-2024
Novartis Institutes for BioMedical Research
2004-2019
<h3>Objective</h3> To examine the role of CD40–CD154 costimulation and effects therapeutic pathway blockade in non-obese diabetic (NOD/ShiLtJ) model Sjögren's syndrome (SS). <h3>Methods</h3> We assessed leucocyte infiltration salivary glands (SGs) from NOD/ShiLtJ mice by immunohistochemistry examined transcriptomics data SG tissue these animals for evidence a CD40 gene signature. Additionally, we dosed MR1 (anti-CD154 antibody) NOD after onset SS-like disease treatment on sialadenitis,...
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurring suppurating lesions of the intertriginous areas, resulting in substantial impact on patients' QOL. HS pathogenesis remains poorly understood. An autoimmune component has been proposed, but disease-specific autoantibodies, autoantigens, or autoreactive T cells have yet to be described. In this study, we identify high prevalence IgM, IgG, and IgA antibodies directed against Nε-carboxyethyl lysine...
Abstract Suitable human models for the development and characterization of topical compounds inflammatory skin diseases such as atopic dermatitis are not readily available to date. We describe here a translational model involving healthy mimicking major aspects AD its application Janus kinase inhibitors. Full thickness abdominal obtained from plastic surgery stimulated in vitro with IL4 IL13 shows molecular features AD. This is evidenced by STAT6 phosphorylation assessed immunohistochemistry...
<h3>Background</h3> T cell-dependent activation of B lymphocytes is a key effector arm the adaptive immune system, resulting in protective antibody responses and long-lived humoral immunity. Such cell often occur germinal centres (GCs); specialized anatomical locations within secondary lymphoid organs. Similar GC-like structures can also be found involved tissue various autoimmune diseases, including salivary glands primary Sjögren9s syndrome (pSS) patients. <h3>Objectives</h3> Previous work...