A5022641523- Psychology of Moral and Emotional Judgment
- Epistemology, Ethics, and Metaphysics
- Language, Metaphor, and Cognition
- Nanoparticle-Based Drug Delivery
- Emotions and Moral Behavior
- Misinformation and Its Impacts
- Action Observation and Synchronization
- Child and Animal Learning Development
- Philosophy and History of Science
- Free Will and Agency
- Social and Intergroup Psychology
- Decision-Making and Behavioral Economics
- Drug Solubulity and Delivery Systems
- Language, Discourse, Communication Strategies
- Pain Management and Placebo Effect
- Embodied and Extended Cognition
- Classical Philosophy and Thought
- Law in Society and Culture
- Ethics in medical practice
- Philosophical Ethics and Theory
- Pediatric Pain Management Techniques
- Ethics in Business and Education
- Deception detection and forensic psychology
- Experimental Behavioral Economics Studies
- Immunotherapy and Immune Responses
University of Zurich
2020-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2017-2024
University of Bern
1988-2024
University of Tübingen
2024
GlaxoSmithKline (United States)
2023-2024
Czech Academy of Sciences, Institute of Philosophy
2022-2023
University of Massachusetts Amherst
2023
Ruhr University Bochum
2013-2022
University of Sheffield
2022
University Hospital Cologne
2021
In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed effects protein adsorption, macrophage uptake, circulation time. Interestingly, necessary to promote a long-circulating particle was dramatically less than what has been previously reported. Overall, our methodology provides rapid screening technique predict behavior in vivo results deliver further insight PEG is facilitate long-circulation.
As the enhanced permeation and retention (EPR) effect continues to be a controversial topic in nanomedicine, we sought examine EPR as function of nanoparticle size, tumor model, location, while also evaluating tumors for mediating factors such microvessel density, vascular permeability, lymphatics, stromal content, tumor-associated immune cells. Tumor accumulation was evaluated 55 × 60, 80 180, 320 nm PRINT particles four subcutaneous flank models (SKOV3 human ovarian, 344SQ murine nonsmall...
In this Letter, we varied targeting ligand density of an EGFR binding affibody on the surface two different hydrogel PRINT nanoparticles (80 nm × 320 and 55 60 nm) monitored effects target-cell association, off-target phagocytic uptake, biodistribution, tumor accumulation. Interestingly, variations in only significantly altered vitro internalization rates for 80 particle. However, vivo, both particle sizes experienced significant changes biodistribution pharmacokinetics as a function...
Abstract In much of the current academic and public discussion, conspiracy theories are portrayed as a negative phenomenon, linked to misinformation, mistrust in experts institutions, political propaganda. Rather surprisingly, however, philosophers working on this topic have been reluctant incorporate negatively evaluative aspect when either analyzing or engineering concept theory . paper, we present empirical data nature from five studies designed test existence, prevalence exact form an...
Abstract Discussions in social psychology overlook an important way which biases can be encoded conceptual representations. Most accounts of implicit bias focus on ‘mere associations’ between features and representations groups. While some have argued that must a richer structure, they said little about what this structure might be. To address lacuna, we build research philosophy cognitive science demonstrating concepts represent dependency relations features. These relations, turn,...
Abstract The concepts expressed by social role terms such as artist and scientist are unique in that they seem to allow two independent criteria for categorization, one of which is inherently normative (Knobe, Prasada, & Newman, 2013). This study presents tests an account the content structure dimension these “dual character concepts.” Experiment 1 suggests a concept represents commitment fulfill idealized basic function associated with role. Background information can affect each...
Causal selection is the cognitive process through which one or more elements in a complex causal structure are singled out as actual causes of certain effect. In this paper, we report on an experiment investigated role moral and temporal factors selection. Our results follows. First, when presented with chain two human agents perform same action after other, subjects tend to judge later agent be cause. Second, impact location almost canceled if did not violate norm while former did. We argue...
Abstract Some of philosophy's most central concepts, including art , friendship and happiness have been argued to be dual character concepts. Their main characteristic is that they encode not only a descriptive dimension but also an independent normative for categorization. This article introduces the class concepts discusses various accounts their content structure. A specific focus will placed on relation two other classes thick natural kind The study demonstrates wide range inherently...
For scientific theories grounded in empirical data, replicability is a core principle, for at least two reasons. First, unless we accept to have rest on the authority of small number researchers, studies should be replicable, sense that its methods and procedure detailed enough someone else conduct same study. Second, results provide solid foundation theorizing, they also most attempts replicating original study produced them would yield similar results. The XPhi Replicability Project...
Generic statements (‘Tigers have stripes’) are pervasive and early-emerging modes of generalization with a distinctive linguistic profile. Previous experimental work found that generics display unique asymmetry between their acceptance conditions the implications typically drawn from them. This paper presents evidence against hypothesis only an asymmetry. Correcting for limitations previous designs, we generalized effect across generics, various kinds explicitly quantified (‘most’, ‘some’,...
ABSTRACT Assertions are the centre of gravity in social epistemology. They vehicles we use to exchange information within scientific groups and society as a whole. It is therefore essential determine under which conditions permitted make an assertion. In this paper argue provide empirical evidence for view that norm assertion justified belief: truth or even knowledge not required. Our results challenge account advocated by, e.g. Williamson (1996), general, more specifically, put into...
Background: The aim of the present study was to analyze incidence, risk factors, and association with long-term outcome postoperative delirium (POD) after transcatheter aortic valve replacement (TAVR). Methods: Six hundred sixty one consecutive patients undergoing TAVR were prospectively enrolled from January 2016 December 2017. POD assessed regularly during ICU-stay using CAM-ICU test. Results: incidence 10.0% ( n = 66). Patients developing predominantly male (65%), had higher EuroSCORE II...
Abstract Philosophers and linguists currently lack the means to reliably identify evaluative concepts measure their intensity. Using a corpus-based approach, we present new method distinguish evaluatively thick thin adjectives like ‘courageous’ ‘awful’ from descriptive ‘narrow,’ value-associated ‘sunny.’ Our study suggests that modifiers ‘truly’ ‘really’ frequently highlight dimension of adjectives, allowing for them be uniquely classified. Based on these results, believe our...
The pseudosciences often bear a striking resemblance to the sciences. Using mimicry account as framework, this paper investigates how appearance of social media posts influences people’s perception content such scientific. We present results two empiri- cal studies. first, preparatory study identifies typical characteristics “scientificness” in inform feature manipulations for main study. then examines what happens if features are systematically manipulated. findings support hypothesis that...
Pseudosciences often bear a striking resemblance to the sciences. This paper in- vestigates how appearance of social media posts influences people’s perception their digital content as scientific. We present results two empirical studies. The first, preparatory study identifies typical characteristics “scientificness” in inform feature manipulations for main study. then examines what happens if features are systematically manipulated. findings support hypothesis that pseudoscientific...
The meaning of being healthy is widely debated, with many suggesting it a multidimensional concept encompassing key dimensions such as the absence disease, presence well-being, and lifestyle. While recent studies indicate that lifestyle may be dominant dimension, remains unclear whether this holds true across populations or if significant differences exist, particularly between laypeople healthcare professionals. Our reveal difference, but surprisingly, in opposite direction what literature...
Abstract A traditional view holds that ignorance is simply the absence of knowledge. This has recently been challenged by Normative Account, which sees as involving a normative failure. In this paper, we argue both perspectives capture important insights. Drawing on three empirical studies, propose two-senses account ignorance, according to there exist two notions ignorance: one normative, other non-normative. We also offer new explanation aspect. Our findings suggest what negative in being...