A5046152306- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Advanced biosensing and bioanalysis techniques
- Sustainable Supply Chain Management
- Environmental Impact and Sustainability
- Microtubule and mitosis dynamics
- 14-3-3 protein interactions
- Glycosylation and Glycoproteins Research
- Chemistry and Chemical Engineering
- Technology Assessment and Management
- Sustainable Industrial Ecology
- Recycling and Waste Management Techniques
- Genetics and Neurodevelopmental Disorders
BioNanoNet
2023
Institut de Biologia Molecular de Barcelona
2005-2010
Université de Montpellier
2008
Centre National de la Recherche Scientifique
2008
Consejo Superior de Investigaciones Científicas
2008
Safe-and-sustainable-by-design (SSbD) is central in the European Chemicals Strategy for Sustainability, yet a common understanding on what SSbD concept and practice still needed. A comparison of current descriptions approaches was made lessons learned were derived from value chain discussions (packaging, textile, construction, automotive, energy materials, electronics, fragrances chains) to help provide input how implement practice. Five important building blocks identified: design, data,...
The heterodimeric ubiquitin conjugating enzyme (E2) UBC13-UEV mediates polyubiquitylation through lysine 63 of (K63), rather than 48 (K48). This modification does not target proteins for proteasome-dependent degradation. Searching potential regulators this variant we have identified four proteins, namely RNF8, KIA00675, KF1, and ZNRF2, that interact with UBC13 their RING finger domains. These domains can recruit, in addition to UBC13, other E2s mediate canonical (K48) polyubiquitylation....
Background Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent tolerance activation of NF-κB by extrinsic signals, are regulated the tagging key proteins with lysine 63-based polyubiquitylated chains, catalyzed conserved ubiquitin conjugating heterodimeric enzyme Ubc13-Uev. Methodology/Principal Findings By applying a selection based on in vivo protein-protein interaction assays compounds from combinatorial...
Abstract The zinc‐coordinated protein motifs known as RING‐finger domains, present on a class of ubiquitin ligases (E3's), recruit ubiquitin‐conjugating enzymes (E2s), tethering them to substrate proteins for covalent modification with ubiquitin. Each domain can different E2s, and these interactions are frequently selective, in that certain domains associate preferentially E2s. This selectivity acquires particular biological relevance when the recruited E2s exert specialized functions. We...
Detection of cell cycle regulators whose aberrant expression or activation influences progression and proliferation is critical for the development efficient diagnostic therapeutic strategies. In particular Cdk1‐cyclin B1 Cdc25 phosphatases are central players partners that coordinate entry into mitosis function proliferation. We have developed non‐genetically encoded fluorescent sensors which specifically recognize Cyclin through molecular interfaces distinct from ATP‐binding pockets active...