Libraries of benzoxanthenes, as well benzochromenes, were efficiently synthesized via one-pot, three-component reactions 2-naphthol, aldehydes, and cyclic 1,3-diketones/malononitrile/ethyl cyanoacetate in the presence catalytic amount ceric ammonium nitrate (CAN) under solvent free conditions. The protocol offers rapid synthesis structurally diverse benzoxanthenes benzochromenes for biologically screening. All compounds evaluated their anti-proliferative activity, several exhibiting...

A fierce dog: method for the continuous in-situ on-demand generation, separation, and reaction of diazomethane in a dual-channel microreactor has been developed (see picture; Diazald=N-methyl-N-nitroso-p-toluenesulfonamide). The microchemical system allows variety reactions to be performed without most common problems preparation, handling, transfer, decomposition. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...

Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration corresponding N-substituted formamides, several representative isocyanide-based organic reactions successfully performed. DIPEA = N,N-diisopropylethylamine.

Hantzsch 1,4-dihydropyridine and polyhydroquinoline derivatives were synthesized in excellent yields aqueous micelles. The reaction is catalyzed by PTSA strongly accelerated ultrasonic irradiation.

Putting osmium in its place: The immobilization of hazardous OsO4 on polymer nanobrushes a microreactor is safe, effective, and green concept. method allows reactions to be performed time- chemical-saving manner, with little environmental impact, as compared spill-over bulk processes.

A transparent dual-channel microreactor with highly enhanced contact area-to-volume ratio was fabricated for efficient photosensitized oxygenations. The shielded polyvinylsilazane (PVSZ) consisting of an upper channel liquid flow and a lower O(2) flow, allows sufficient phase along the parallel channels through gas permeable PDMS membrane maintaining saturated solution. Under full exposure reactants to light, reactions in high concentration are completed minutes rather than hours that it...

An operationally simple and high yielding protocol for the synthesis of polyfunctional pyrazoles has been developed through one-pot, three-component coupling aldehydes, 1,3-dicarbonyls, diazo compounds as well tosyl hydrazones. The reaction proceeds a tandem Knoevenagel condensation, 1,3-dipolar cycloaddition, transition metal-free oxidative aromatization sequence utilizing molecular oxygen green oxidant. scope was studied by varying aldehyde, 1,3-dicarbonyl, component individually.

An integrated microfluidic system for multiple reactions and separations of hazardous ethyl diazoacetate is presented. The techniques include: a droplet technique liquid–liquid and/or gas–liquid separation in situ generation the toxic reagent, dual channel membrane based on cheap polymeric microseparator separation, capillary microreactor carrying out cascade sequential continuous manner.

1,2,3,4-Tetrahydro-β-carbolines were coupled with α-keto vinyl azides through an unprecedented visible light-Ru(bpy)3(PF6)2/TBHP mediated photocascade strategy that involves photosensitization, photoredox catalysis and [3 + 2] cycloaddition reaction. The scope scale-up feasibility of the was demonstrated by synthesizing 18 different fused β-carbolines in moderate to good yields using batch continuous flow microreactor. This operationally simple synthetic protocol allows formation one C-C two...

A novel strategy for the synthesis of imidazo[1,2-a]pyridines via efficient catalyst/metal-free annulations α-keto vinyl azides and 2-aminopyridines is described. Several were synthesized from readily available obtained in highly pure form by simply evaporating reaction solvent. This remarkably high yielding atom economical protocol allows formation three new C–N bonds through cascade reactions rearrangements.

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTDiversity Oriented Synthesis of Benzimidazole and Benzoxa/(thia)zole Libraries through Polymer-Supported Hypervalent Iodine ReagentAtul Kumar*, Ram Awatar Maurya, Pervez AhmadView Author Information Medicinal Process Chemistry Division, Central Drug Research Institute, Lucknow-226001, India* Corresponding author. E-mail: [email protected]Cite this: J. Comb. Chem. 2009, 11, 2, 198–201Publication Date (Web):January 16, 2009Publication History...

A triple-channel microreactor fabricated by means of a soft-lithography technique was devised for efficient biphasic gas-liquid reactions. The excellent performance the demonstrated carrying out photosensitized oxygenations α-terpinene, citronellol, and allyl alcohols.

Fused β-carbolines were synthesized <italic>via</italic> a visible light photoredox catalyzed oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade in batch and flow microreactors.

Abstract Structurally diverse imidazole derivatives were synthesized by a visible‐light/[Ru(bpy) 3 ][(PF 6 ) 2 ]‐mediated coupling of vinyl azides and secondary amines in flow microreactors. This operationally simple atom‐economical protocol allows the formation three new CN bonds through functionalization sp CH adjacent to nitrogen atom. In order get mechanistic insight reaction, several control experiments carried out discussed.

The sustainable green chemistry associated with lignocellulosic biomass is of current interest for producing various chemical feedstocks via multi-step transformation processes. Here we introduce a platform system the multicomponent cascade natural resources. We demonstrate concept by developing an integrated continuous two-step microfluidic as tandem direct conversion fructose to diverse furan chemicals excellent yields up 99% decarbonylation, etherification, oxidation and hydrogenolysis...

A novel and efficient visible-light 2,4-dinitrophenol (2,4-DNP) mediated photoannulation of α-azidochalcones into 2,5-diaryloxazoles was developed. The carbon–carbon double bond α-azidochalcone cleaved, leading to the formation new C–O C–N bonds in photoannulation. Control experiments were carried out, a plausible mechanism proposed. scope reaction studied by synthesizing series including two naturally occurring oxazoles (Texamine Balsoxin) excellent yields.