A5056360207- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Pancreatic function and diabetes
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Vestibular and auditory disorders
- Motor Control and Adaptation
- Neuroscience and Neuropharmacology Research
- Action Observation and Synchronization
- Porphyrin and Phthalocyanine Chemistry
Inserm
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Institut NeuroMyoGène
2020-2024
Université Claude Bernard Lyon 1
2020-2024
Hôpital Saint Eloi
2022
Institute for Neurosciences of Montpellier
2021-2022
Institut Pasteur
2021
Max Planck Institute of Immunobiology and Epigenetics
2021
Institut de Biologie Paris-Seine
2021
Université de Montpellier
2021
Abstract The cellular mechanisms underlying axonal morphogenesis are essential to the formation of functional neuronal networks. We previously identified autism-linked kinase NUAK1 as a central regulator axon branching through control mitochondria trafficking. However, (1) relationship between mitochondrial position, function and (2) downstream effectors whereby regulates remain unknown. Here, we report that recruitment synaptic boutons supports collateral branches stabilization rather than...
Abstract Gephyrin ( GPHN ) regulates the clustering of postsynaptic components at inhibitory synapses and is involved in pathophysiology neuropsychiatric disorders. Here, we uncover an extensive diversity transcripts that are tightly controlled by splicing during mouse human brain development. Proteomic analysis reveals least a hundred isoforms incorporated Glycine gamma-aminobutyric acid A receptors containing synapses. They exhibit different localization properties, altering expression...
ABSTRACT The precise regulation of the cellular mechanisms underlying axonal morphogenesis is essential to formation functional neuronal networks. We previously identified autism-candidate kinase NUAK1 as a central regulator axon branching in mouse cortical neurons through control mitochondria trafficking. How does local mitochondrial position or function regulate during development? Here, we characterized metabolic developing and report marked decorrelation between elongation collateral...
Abstract Gephyrin (GPHN) regulates the clustering of postsynaptic components at inhibitory synapses and is involved in pathophysiology neuropsychiatric disorders. Here, we uncover an extensive diversity GPHN transcripts that are tightly controlled by splicing during mouse human brain development. Proteomic analysis reveals least a hundred isoforms incorporated Glycine GABA-A receptors containing synapses. They exhibit different localization properties, altering expression level one isoform...