A5007891385- Neurofibromatosis and Schwannoma Cases
- Pain Management and Treatment
- Pain Mechanisms and Treatments
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Artificial Intelligence in Healthcare and Education
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Transcranial Magnetic Stimulation Studies
- Hereditary Neurological Disorders
- Biomedical Text Mining and Ontologies
- Anesthesia and Pain Management
- Pharmacological Effects and Toxicity Studies
- Nerve Injury and Rehabilitation
- Fetal and Pediatric Neurological Disorders
- Neuroendocrine Tumor Research Advances
- Epilepsy research and treatment
- Topic Modeling
- Psychosomatic Disorders and Their Treatments
- Sarcoma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Laser Applications in Dentistry and Medicine
- Pain Management and Opioid Use
Burdenko Neurosurgery Institute
2020-2024
Moscow Clinical Scientific Center
2021-2024
Ministry of Health of the Russian Federation
2021-2022
Sechenov University
2020
Neurofibromatoses are a group of genetic disorders with predisposing for central and peripheral nervous system tumor development. The includes three entities: neurofibromatosis type I, II schwannomatosis, which characterized by gradual phenotype development have partially overlapping spectrum manifestations, complicates diagnosis establishing, especially at the stage clinical onset. At same time, emergence new pathogenetic therapy high risk transmission to descendants actualize necessity...
Hypothalamic hamartoma (HH) is a dysplastic lesion fused with hypothalamus and followed by epilepsy, precocious puberty behavioral disorders. Up to 50% of patients become free seizures after surgery, but various complications occur in 1/4 cases. Radiofrequency thermocoagulation, laser interstitial thermal therapy stereotactic radiosurgery (SRS) are alternative treatment options.To define the indications for SRS HH clarify irradiation parameters.Twenty-two epilepsy underwent at Moscow...
Identifying adverse events in clinical documents is demanded retrospective research and prospective monitoring of treatment safety cost-effectiveness. We proposed evaluated a few methods semi-automated muscle weakness detection preoperative notes for larger project on predicting paresis by images. The combination semi-expert machine learning demonstrated maximized sensitivity = 0.860 specificity 0.919, largest AUC 0.943 with 95% CI [0.874; 0.991], outperforming each method used individually....
The automated detection of adverse events in medical records might be a cost-effective solution for patient safety management or pharmacovigilance. Our group proposed an information extraction algorithm (IEA) detecting neurosurgery using documents written natural rich-in-morphology language. In this paper, we challenge to optimize and evaluate its performance the any extremity muscle weakness clinical texts. shows accuracy 0.96 ROC AUC = easily implemented other domains.
Despite the numerous analgesic drugs, prevalence of intractable neuropathic pain remains high making up about 5%. Intervention methods, including methods chronic electrostimulation, are used to treat these patients. Spinal cord stimulation (SCS) is most common surgical method worldwide that replaced destructive and ablation procedures. Currently, tonic SCS, HF-10 burst SCS applied, choice based on clinical neurophysiological data. Also, introduction nanomaterial-enabled neural could...
Neurofibromatosis 2 is one of the most prevalence disease among phakomatoses characterized by appearance new central and peripheral nerve system tumors. The main treatment for this patient a surgery, but in real time we observe significant changes rehabilitation patients including radiation therapy pharmacotherapy. In paper, present case different options young female with neurofibromatosis. She completed surgical treatment, Gamma Knife radiosurgery bevacizumab on stage disease. Development...
Meningioma is the most common primary tumor of central nervous system. Traditional classification based on histological properties tumors and distinguishes different grades meningioma malignancy. However, knowledge about molecular mechanisms provided new data genetic features meningiomas. The authors analyze current available main driver mutations, classifications characteristics potential targets for therapy.Менигиомы — самые распространенные первичные опухоли центральной нервной системы....
To identify the characteristics of pain syndrome in patients with schwannomas depending on genetic predisposition.
Our study aimed to compare the capability of different word embeddings capture semantic similarity clinical concepts related complications in neurosurgery at level medical experts. Eighty-four sets (based on Word2vec, GloVe, FastText, PMI, and BERT algorithms) were benchmarked a clustering task. FastText model showed best close expertise group terms by their meaning (adjusted Rand index = 0.682). Word embedding models can accurately reflect concepts' linguistic similarities, promising robust...
Implementing the best research principles initiates an important shift in clinical culture, improving efficiency and level of evidence obtained. In this article, we share our own view on practice experience introducing it into scientific activities N.N. Burdenko National Medical Research Center Neurosurgery (Moscow, Russian Federation). While being adherent to described percentage publications international journals has increased from 7% 27%, with overall gain number articles by 2 times...
Our pilot study aimed at exploratory radiogenomic data analysis in patients with NF2-associated schwannomatosis (formerly neurofibromatosis type II) to assume the potential of image biomarkers this pathology. Fifty-three unrelated (37 (69.8%) women, avg. age 30.2 ± 11.2 y.o.) were enrolled study. First-order, gray-level co-occurrence matrix (GLCM), run length (GLRLM), and geometry-based statistics calculated (3718 features per region interest). We demonstrated imaging patterns statistically...
Schwannomatoses is a new classification unit for all the hereditary diseases caused by chromosome 22 damage followed multiple benign neoplasms of peripheral and central nervous system. Schwannomatosis occurs as result to different genes: NF2, SMARCB1, LZRT1, loss heterozygosity long arm 22. Nevertheless, clinical manifestations are similar. Molecular diagnostics not only confirms diagnosis, but also predicts course disease. Thus, most severe observed in patients with violation semantic...
Glioblastoma (GB) is one of the most aggressive primary brain tumors. Analysis molecular genetic factors affecting prognosis in patients with GB an important direction fundamental and clinical researches. There are literature data on effect TERT gene mutations, MGMT methylation IDH1/2 status overall survival GB.To evaluate incidence promoter mutations adults to analyze relapse-free survival, as well interaction these mutations.The study included 56 (26 women 30 men) histologically verified...
Нейрофиброматоз 2 типа - редкое генетическое заболевание, этиологическим фактором развития которого являются мутации в гене-онкосупрессоре NF2, кодирующем белок мерлин. В обзоре подробно описаны структура, функции и посттрансляционные модификации мерлина, освещены клинические особенности нейрофиброматоза типа, известные клинико-генетические корреляции, а также представлена информация о сайтах связывания мерлина функциональном вкладе расположенных них мутаций, что закладывает базис...