A5055191188- Skin Protection and Aging
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Hair Growth and Disorders
- Religion, Theology, History, Judaism, Christianity
- Cancer Immunotherapy and Biomarkers
- German legal, social, and political studies
- melanin and skin pigmentation
German Cancer Research Center
2019-2023
DKFZ-ZMBH Alliance
2019-2023
Heidelberg University
2019-2023
Abstract Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has not been analyzed systematically yet. We have used single-cell RNA sequencing to analyze the transcriptomes of more than 5,000 fibroblasts from a sun-protected area in healthy donors. Our results define four main subpopulations that can be spatially localized show differential secretory, mesenchymal pro-inflammatory functional...
Abstract Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its high incidence and metastatic potential. It may progress from actinic keratosis (AK), precancerous lesion, or the in situ carcinoma, Bowen’s disease (BD). During this progression, malignant keratinocytes activate dermal fibroblasts into tumor promoting cancer-associated (CAFs), whose origin emergence remain largely unknown. Here, we generate analyze >115,000 single-cell transcriptomes healthy...
The dermal sheath (DS) is a population of mesenchyme-derived skin cells with emerging importance for homeostasis. DS includes hair follicle stem cells, which exhibit self-renewal and serve as bipotent progenitors papilla (DP) cells. Upon aging, deficiencies in their number reduced. While the mice has been examined considerable detail, our knowledge human DS, pathways contributing to its differentiation capacity potential paracrine effects important tissue regeneration aging very limited....
Summary Fibroblasts are the main dermal cell type and essential for architecture function of human skin. Important differences have been described between fibroblasts localized in distinct layers, these cells also known to perform varied functions. However, this phenomenon has not analyzed comprehensively yet. Here we used single-cell RNA sequencing analyze >15,000 from a sun-protected area young old donors. Our results define four fibroblast subpopulations that can be spatially...