A5030427075- Prostate Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Soft Robotics and Applications
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Surgical Simulation and Training
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Urologic and reproductive health conditions
- Medical Image Segmentation Techniques
- Radiation Dose and Imaging
- Ovarian cancer diagnosis and treatment
- Renal and related cancers
- Adrenal and Paraganglionic Tumors
- Ultrasound and Hyperthermia Applications
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Urology and Nephrology Studies
Brigham and Women's Hospital
2016-2025
Harvard University
2015-2024
Dana-Farber Cancer Institute
2003-2023
Lemuel Shattuck Hospital
2023
University College London Hospitals NHS Foundation Trust
2022
University College London
2022
University Medical Center Hamburg-Eppendorf
2022
Universität Hamburg
2022
Guided Therapeutics (United States)
2013-2017
Harvard University Press
2002-2012
To evaluate the benefits of computed tomographic (CT) fluoroscopy-guided interventions and assess radiation exposures incurred with CT fluoroscopy.A 6-month period use fluoroscopy to guide abdominal biopsy procedures catheter drainage was analyzed. Efficacy measures needle placement procedure room times were compared those preceding 6 months during which conventional used. fluoroscopic estimated for two methods.The sensitivity negative predictive values success rate aspiration or drainages...
To evaluate the initial clinical experience of magnetic resonance (MR) imaging-guided percutaneous cryotherapy renal tumors.Twenty-six tumors (diameter range, 1.0-4.6 cm; mean, 2.6 cm) in 23 patients were treated with 27 cryoablation procedures by using a protocol approved human subjects committee at authors' institution. The study complied Health Insurance Portability and Accountability Act. Written informed consent was obtained from each patient. There 17 men six women an average age 66...
PURPOSE: To describe the cryoablation of liver tumors by using a percutaneous approach and intraprocedural magnetic resonance (MR) imaging monitoring to assess feasibility safety procedure. MATERIALS AND METHODS: Fifteen hepatic (mean diameter, 2.9 cm) in 12 patients were treated (18 total cryoablations). Fourteen metastases one was hemangioma; all proved at biopsy. By 0.5-T open MR system, cryoneedles placed lesions ablated real-time monitoring. Clinical signs symptoms assessed laboratory...
To estimate patient dose and personnel exposure from phantom measurements during computed tomographic (CT) fluoroscopy, to use the estimates provide users with information, recommend methods reduce exposure.Surface was estimated on a CT dosimetric by using thermoluminescent (TLD) pencil chamber measurements. Scatter scattered radiation measured at distances of 10 cm 1 m phantom. exposures without placement lead drape surface adjacent scanning plane were compared.Phantom rates ranged 2.3 10....
We report the findings of a transperineal magnetic resonance image (MRI) guided biopsy prostate in man with increasing specific antigen who was not candidate for transrectal ultrasound biopsy.Using an open configuration 0.5 Tesla MRI scanner and pelvic coil, random sextant sample obtained under real time guidance from peripheral zone gland as well single core each defined lesion. The patient had previously undergone proctocolectomy ulcerative colitis and, therefore, biopsy. Prior attempts to...
Abstract Purpose: Resistance to imatinib mesylate is emerging as a clinical challenge in patients with metastatic gastrointestinal stromal tumors (GIST). Novel patterns of progression have been noted number these patients. The objective this study was correlate molecular and radiologic imitinib-refractory disease existing conventional criteria for progression. Experimental Design: Patients GIST treated were followed serial computed tomography/magnetic resonance imaging...
To establish the feasibility of performing combined positron emission tomography (PET)/computed (CT)-guided biopsy abdominal masses by using previously acquired PET/CT images registered with intraprocedural CT images.In this HIPAA-compliant institutional review board-approved study, 14 patients underwent clinically indicated percutaneous (mean size, 3.3 cm; range, 1.2-5.0 cm) in liver (n = 6), presacral soft tissue 3), retroperitoneal lymph nodes 2), spleen and pancreas 1). obtained no more...
Purpose To determine the detection rate, clinical relevance, Gleason grade, and location of prostate cancer ( PCa ) diagnosed with safety an in-bore transperineal 3-T magnetic resonance (MR) imaging–guided biopsy in a clinically heterogeneous patient population. Materials Methods This prospective retrospectively analyzed study was HIPAA compliant institutional review board approved, informed consent obtained. Eighty-seven men (mean age, 66.2 years ± 6.9) underwent multiparametric endorectal...
Percutaneous Image-Guided Cryoablation of Hepatic Tumors: Single-Center Experience With Intermediate to Long-Term OutcomesDaniel I. Glazer1, Servet Tatli2, Paul B. Shyn1, Mark G. Vangel3, Kemal Tuncali1 and Stuart Silverman1Audio Available | Share
ABSTRACT Background Prostate cancer (PCa) treatment often involves systemic therapies with varying mechanisms of action, affecting individuals differently. Implantable microdevices (IMDs) are designed to test multiple drugs within a patient's tumor, but the feasibility MRI‐guided placement in PCa has not been evaluated. Purpose To provide proof concept for placing IMDs into lesions MRI guidance predict patient‐specific responses therapies. Study Type Prospective. Population Fifteen...
Radiofrequency Ablation of Thoracic Lesions: Part 2, Initial Clinical Experience—Technical and Multidisciplinary Considerations in 30 PatientsEric vanSonnenberg1 Sridhar Shankar1 2 3, Paul R. Morrison1, Rashmi T. Nair1 Stuart G. Silverman1 Michael Jaklitsch4 5, Franklin Liu1 6, Lawrence Cheung1 Kemal Tuncali1 Arthur Skarin7 David J. Sugarbaker4 5Audio Available | Share
Percutaneous ablation of renal cell carcinoma has the potential to be as effective partial nephrectomy. Because entire tumor cannot examined at pathology, diagnosis relies solely on imaging and percutaneous biopsy. Diagnoses cancer have been rendered using alone in some clinical trials ablation. If these inadvertently included benign masses, efficacy was overestimated. Therefore, we sought determine prevalence masses a population patients referred for presumed carcinoma.Twenty-seven were by...
Purpose: To retrospectively evaluate whether intravenous furosemide, either alone or in addition to saline, improved depiction of the normal urinary collecting system at multi–detector row computed tomographic (CT) urography. Materials and Methods: Institutional review board approval for patient images medical records was obtained; informed consent not required this HIPAA-compliant study. Excretory phase from CT urography 87 patients (44 women, 43 men; age range, 21–83 years; mean, 53 years)...
We sought to determine the safety and feasibility of percutaneous MRI-guided cryotherapy in care patients with refractory or painful metastatic lesions soft tissue bone adjacent critical structures.Twenty-seven biopsy-proven (n = 17) 10) 22 (15 men, seven women; age range, 24-85 years) were managed cryotherapy. The mean lesion diameter was 5.2 cm. Each encasing one more structures, including bowel, bladder, major blood vessels. A 0.5-T open interventional MRI system used for cryoprobe...
Purpose To demonstrate the utility of a robotic needle-guidance template device as compared to manual for in-bore 3T transperineal magnetic resonance imaging (MRI)-guided prostate biopsy. Materials and Methods This two-arm mixed retrospective-prospective study included 99 cases targeted biopsies. The biopsy needles were aimed at suspicious foci noted on multiparametric MRI using (historical control) with template. following data obtained: accuracy average closest needle placement focus,...
Image guidance improves tissue sampling during biopsy by allowing the physician to visualize tip and trajectory of needle relative target in MRI, CT, ultrasound, or other relevant imagery. This paper reports a system for fast automatic localization visualization MRI that has been developed tested context an active clinical research program prostate biopsy. To best our knowledge, this is first reported application also leverages deep neural networks segmentation needles across biomedical...
Abstract BACKGROUND This study was designed to estimate the rates of late genitourinary (GU) and rectal toxicity after magnetic resonance image (MRI)‐guided prostate brachytherapy exclusively or in conjunction with external beam radiation therapy (EBRT). METHODS Between November 1997 April 2002, 201 patients category T1C carcinoma (according 2002 American Joint Committee on Cancer staging criteria), specific antigen levels < 10 ng/mL, biopsy Gleason score 3 + 4 disease were treated...
The objective of our study was to report the occurrence benign inflammatory nodules that develop in or near applicator tracks after percutaneous radiofrequency ablation and cryoablation renal tumors.Benign occur rarely tumors may mimic tumor seeding track.