A5101412845- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Nutritional Studies and Diet
- Hedgehog Signaling Pathway Studies
- Genomic variations and chromosomal abnormalities
- Radiomics and Machine Learning in Medical Imaging
- Neurological and metabolic disorders
- Diet, Metabolism, and Disease
- Glycogen Storage Diseases and Myoclonus
- Neurological disorders and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Prostate Cancer Treatment and Research
- DNA Repair Mechanisms
- Clusterin in disease pathology
- Neuroendocrine Tumor Research Advances
- Molecular Biology Techniques and Applications
- Genomics and Chromatin Dynamics
- Paraoxonase enzyme and polymorphisms
- Biomarkers in Disease Mechanisms
Kocaeli Üniversitesi
2016-2022
Sağlık Bilimleri Üniversitesi
2021
Nibrin, encoded by the NBN gene, participates in DNA repair. Mutations gene lead to Nijemen breakage syndrome, which may result several types of diseases, particularly susceptibility cancer, including breast cancer. Polymorphic variants and defective mutations occurring increase risk cancer through double-stranded break repair mechanism. The aim present study was investigate a possible association between genetic variants, 924 T>C, 8360 G>C 30537 G>C, women with Locus-specific primers were...
The aim of the study was to investigate association paraoxonase 1 (PON1) polymorphism, PON1/arylesterase (ARE) activity and oxidative stress index (OSI) in breast cancer (BC) patients with type 2 diabetes (DM).Our group consisted 30 healthy women (HV group) 66 female BC patients. were divided into two groups: those (n=37) without DM (n=29) (BDM NBDM group). Genotyping PON1 Q192R L55M polymorphisms done by polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP)...
Bladder cancer is an important health problem which ranks 4th among most frequently seen types in men. In our study we aimed to investigate the correlations urothelial type bladder polymorphisms, ApaI, BsmI, FokI, and TaqI, prevalently observed vitamin D receptor (VDR) gene plasma levels a Turkish population.Our included 101 patients 109 control subjects. Plasma 25(OH)D were determined using HPLC method VDR polymorphisms with PCR-RFLP method.A statistically significant intergroup difference...
Objective: Breast cancer is the most common type of in women worldwide.It indicated that increased body mass index elevates risk developing breast cancer, worsens prognosis, and decreases survival.Several polymorphisms adiponectin have been shown to affect serum levels their association with cancer.The aim this study was investigate relationship between 45T/G 276 G/T gene polymorphism East Marmara region. Materials Methods:A case-control performed 97 patients 101 controls order evaluate...
The role of vitamin D has previously been determined in autoimmune and malignant thyroid diseases. We aimed to identify the haplotype distribution single nucleotide polymorphisms (SNPs) receptor (VDR) gene, which suggested play a pathogenesis differentiated cancers benign diseases.Two hundred sixteen patients, 113 with 103 cancers, together same number healthy controls, were included study. FokI, BsmI, ApaI, TaqI SNPs VDR analyzed all participants using PCR-RFLP method.When patients or...
Background The role of vitamin D has previously been determined in autoimmune and malignant thyroid diseases. We aimed to identify the haplotype distribution single nucleotide polymorphisms (SNPs) receptor (VDR) gene, which suggested play a pathogenesis differentiated cancers benign Materials methods Two hundred sixteen patients, 113 with 103 cancers,together same number healthy controls, were included study. FokI, BsmI, ApaI, TaqI SNPs VDR analyzed all participants using PCR-RFLP method....
Amaç: TP53 geni temel olarak DNA tamiri, apoptozis, hücre yaşlanması ve döngüsü kontrolünde görev alan en önemli tümör baskılayıcı genlerden biridir. rs1042522 (Arg72Pro) polimorfizmi baskılama sırasında P53 protein yapısında değişikliğe neden olan bir polimorfizmdir. Bu verilere dayanarak, bu çalışmanın amacı meme kanseri riski arasındaki ilişkiyi araştırmaktır.Yöntem: için 508 kanserli kadın hastadan 367 sağlıklı kadından alınan periferik kanlardan izole edilerek PCR-RFLP yöntemi ile...
Objective: To investigate the effects of vitamin D levels and receptor (VDR) BsmI, FokI, TaqI, ApaI gene polymorphisms on prostate cancer (PCa) diagnosis in Turkish men with high prostate-specific antigen (PSA) during screening.Materials Methods: Patients who were admitted to outpatient clinic elevated PSA scheduled for transrectal biopsy included.Patients diagnosed PCa divided into two groups either localized disease (low/intermediate/high risk) or metastatic subgroup analysis.The control...
The aim of the study was to evaluate role well-characterized vitamin D receptor (VDR) gene polymorphisms, BsmI (rs 1544410), ApaI 7975232), TaqI 731236), and FokI 10735810) their haplotypes in pathogenesis breast cancer Turkish women.The subjects consisted women including 331 patients 345 healthy controls. After conventional DNA isolation genotyping done by a PCR-RFLP method, haplotype analysis performed using Haploview 4.2.Haplotype different combinations revealed that frequencies Fbt, fbt,...
Abstract Advanced-stage liver metastatic Colorectal Cancer (CRC) disease remission rates are markedly low, often with less time for life-saving but challenging medical procedures and physically demanding regimens of neoadjuvant chemotherapies. Medical decisions supported by patient-specific genomic information may improve cancer prognosis, long-term rates, overall patient health. Understanding the landscape metastasis respect to primary tumors can help clinical decision-making that result in...