A5050209868- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
Medical University of Graz
2023-2024
Helicobacter pylori (H. pylori) uses various strategies that attenuate mucosal immunity to ensure its persistence in the stomach. We recently found evidence H. might modulate natural killer group 2, member 2 (NKG2D) system. The NKG2D receptor and ligands are a major activation system of cytotoxic T cells, which important for tumor immunosurveillance. allows recognition elimination infected transformed however viruses cancers often subvert activation. Here we aimed identify potential evasion...
Summary IBD is characterized by altered immune reactions and infections are thought to trigger the chronic inflammatory response in IBD. The gut represents a productive reservoir for SARS-CoV-2 aforementioned factors together with immunosuppression used treat likely influencing outcomes of patients COVID-19. We large small intestinal organoids from controls comparatively assess transcriptional epithelium during SARS- CoV-2 infection. Our analysis showed that epithelia exhibit reduced viral...