A5078609947- Pomegranate: compositions and health benefits
- Phytochemicals and Antioxidant Activities
- Tea Polyphenols and Effects
- Sesame and Sesamin Research
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
- Curcumin's Biomedical Applications
- Cynara cardunculus studies
- Extracellular vesicles in disease
- Diet and metabolism studies
- Sirtuins and Resveratrol in Medicine
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Retinoids in leukemia and cellular processes
- Paraoxonase enzyme and polymorphisms
- Nutritional Studies and Diet
- Nuclear Receptors and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Metabolomics and Mass Spectrometry Studies
- Herbal Medicine Research Studies
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Natural product bioactivities and synthesis
- Bioactive Compounds in Plants
- Cancer, Lipids, and Metabolism
Centro de Edafología y Biología Aplicada del Segura
2018-2025
Consejo Superior de Investigaciones Científicas
2018-2025
Centre d'Etudes Biologiques de Chizé
2018-2025
Universidade Nova de Lisboa
2021-2024
Instituto de Biologia Experimental e Tecnológica
2021-2024
University of Lisbon
2023
Quality Research
2018-2019
Scope Dietary polyphenols may protect against breast cancer. However, it is unknown whether reach human malignant tumors in molecular forms and(or) at concentrations likely to act Methods and Results Ninteen cancer patients consumed three capsules daily from biopsy-confirmed diagnosis surgery (6 ± 2 days). The contained pomegranate, orange, lemon, olive, cocoa, grapeseed extracts plus resveratrol, providing 37 different phenolics (473.7 mg), theobromine caffeine (19.7 mg). A total of 101...
The consumption of pomegranate juices and extracts has long been linked to many health benefits beyond nutrition, described mainly by innumerable preclinical studies. However, the European Food Safety Authority (EFSA) concluded in 2010 that a cause effect relationship could not be established between pomegranate-derived products all claims presented. There are no additional EFSA opinions on specifically addressed last decade. This review comprehensively compiles human studies conducted...
Some polyphenol-derived metabolites reach human breast cancer (BC) tissues at concentrations that induce cell senescence. However, this is unknown for isoflavones, curcuminoids, and lignans. Here, their metabolic profiling in normal (NT) malignant (MT) mammary of newly-diagnosed BC patients the tissue-occurring metabolites' anticancer activity are evaluated.Patients (n = 26) consumed 3 capsules/day (turmeric, red clover, flaxseed extracts plus resveratrol; 296.4 mg phenolics/capsule) from...
Scope Recent evidence demonstrates that resveratrol (RSV) metabolites, but not free RSV, reach malignant tumors (MT) in breast cancer (BC) patients. Since these as detected MT, do exert short‐term antiproliferative or estrogenic/antiestrogenic activities, long‐term tumor‐senescent chemoprevention has been hypothesized. Consequently, here, for the first time, whether physiologically relevant RSV metabolites can induce senescence BC cells is investigated. Methods and Results Human MCF‐7...
The intake of hesperidin-rich sources, mostly found in orange juice, can decrease cardiometabolic risk, potentially linked to the gut microbial phase-II hesperetin derivatives. However, low hesperidin solubility hampers its bioavailability and metabolism, yielding a high inter-individual variability (high vs. low-producers) that prevents consistent health-related evidence. Contrarily, human metabolism (lemon) eriocitrin is hardly known. We hypothesize higher (orange) might yield more...
ABSTRACT Hydroxytyrosol (HT) consumption is associated with healthy outcomes. Specifically, its ability to modulate microRNA (miRNA) expression has been described. However, whether HT influences the secretion of extracellular vesicles (EVs) and their transported miRNAs remains unknown. Here, following administration, we explored potential changes in EV miRNA cargo during postprandial state after 1 week daily intake. Twelve participants received, first, a single 25 mg dose (postprandial...
ABSTRACT Milk exosomes (EXOs) enhance polyphenols’ bioavailability, but their potential for oral administration remains underexplored. Ellagic acid (EA) is poorly bioavailable. We investigate whether EA encapsulated in EXOs (EXO‐EA) consumed orally improves bioavailability and (or) modulates gut microbiota. For 2 weeks, BALB/c mice received EXO, non‐encapsulated (NEA), or EXO‐EA (0.27 mg EA/kg bw) orally. Targeted untargeted metabolomics (UPLC‐qTOF‐MS), fecal SCFAs (GC‐MS), microbiota...
ADVERTISEMENT RETURN TO ISSUEViewpointNEXTIn Vitro Research on Dietary Polyphenols and Health: A Call of Caution a Guide How To ProceedMaría Ángeles Ávila-GálvezMaría Ávila-GálvezLaboratory Food & Health, Group Quality, Safety Bioactivity Plant Foods, CEBAS-CSIC, Post Office Box 164, Campus de Espinardo, 30100 Murcia, SpainMore by María Ávila-Gálvez, Antonio González-SarríasAntonio González-SarríasLaboratory González-Sarríashttp://orcid.org/0000-0002-3407-0678, Juan Carlos Espín*Juan...
While preclinical studies suggest the breast cancer (BC) chemopreventive effects of dietary polyphenols, human evidence is still very weak. The huge existing in vitro–in vivo gap mainly due to plethora potential reported by vitro that usually assay polyphenols as occurring food (beverages, extracts, foods) and/or derived aglycone metabolites with doubtful physiological relevance. Since phase-II can reach systemic tissues such malignant tumors, we aimed here compare for first time...
Urolithin A glucuronide is deconjugated to free urolithin in systemic inflammation.
Sesquiterpene lactones - such as those found in chicory are considered promising bioactive compounds. These small molecules have shown several health benefits for various diseases, including brain disorders. However, it is unknown whether these compounds can cross the blood-brain barrier (BBB), and which could be effects on microvascular endothelial cells. We show that six sesquiterpene evaluated an vitro model of BBB different capacities to transported through barrier. Costunolide presented...
Echinacea purpurea L. (EP) preparations are globally popular herbal supplements known for their medicinal benefits, including anti-inflammatory activities, partly related to phenolic composition. However, regarding use the management of inflammation-related intestinal diseases, knowledge about fate orally ingested constituents throughout human gastrointestinal tract and exposition in vitro digested extracts relevant inflammatory models unknown. This study investigated first time impact...
Recently, the development of functional beverages has been enhanced to promote health and nutritional well-being. Thus, fermentation plant foods with lactic acid bacteria can enhance their antioxidant capacity others like anti-inflammatory activity, which may depend on variations in total content profile (poly)phenols. The present study aimed investigate impact two strains Lactiplantibacillus plantarum several herbal infusions from thyme, rosemary, echinacea, pomegranate peel (poly)phenolic...
The polyphenol resveratrol (RSV) undergoes extensive phase II metabolism, which limits its bioavailability and bioactivity, including anticancer effects. Growing preclinical evidence reinforces milk-derived exosomes (EXOs) as promising nanocarrier drugs bioactives delivery systems. Herein, to overcome the mentioned RSV's drawbacks, EXOs were loaded with RSV (EXO-RSV) evaluate brain in Sprague-Dawley rats vitro antiproliferative effects against human neuroblastoma SH-SY5Y glioblastoma U-87MG...
Consumption of pomegranate decreases, in a time-dependent fashion, metabolic endotoxemia patients with newly diagnosed colorectal cancer.
The gut microbial-derived metabolites of ellagitannins and ellagic acid, urolithins (Uros) are well-established anti-cancer according to preclinical studies. However, their efficacy is limited in systemic tissues, including the brain, by phase-II metabolism. Exosomes (EXOs), extracellular vesicles involved cell signaling with ability cross blood-brain barrier (BBB), could protect polyphenols from Therefore, we loaded milk EXOs Uro-A, Uro-B or IsoUro-A evaluate brain delivery anticancer...
The ubiquitin-proteasome system (UPS) is a critical cellular mechanism involved in protein turnover, influencing processes such as cell cycle regulation, gene expression, and stress responses. Dysregulation of the UPS contributes to pathogenesis chronic diseases, including neurodegeneration, cardiovascular disorders, cancer. This review explores potential circulating phenolic metabolites — bioactive derived from dietary (poly)phenols modulators activity. Using comprehensive analysis, we...