A5074136729- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Dermatologic Treatments and Research
- Spinal Dysraphism and Malformations
- Pain Mechanisms and Treatments
- Restless Legs Syndrome Research
- Genetic and rare skin diseases.
- Botulinum Toxin and Related Neurological Disorders
- Herpesvirus Infections and Treatments
- Skin Diseases and Diabetes
- Toxin Mechanisms and Immunotoxins
- Prion Diseases and Protein Misfolding
- Migraine and Headache Studies
Centro Neurolesi Bonino Pulejo
2020
University of Palermo
2007-2018
Baden-Wuerttemberg Cooperative State University
2016
Background and purpose Tauroursodeoxycholic acid ( TUDCA ) is a hydrophilic bile that produced in the liver used for treatment of chronic cholestatic diseases. Experimental studies suggest may have cytoprotective anti‐apoptotic action, with potential neuroprotective activity. A proof principle approach was adopted to provide preliminary data regarding efficacy tolerability series patients amyotrophic lateral sclerosis ALS ). Methods As principle, using double‐blind placebo controlled design,...
Our objective was to investigate incidence of amyotrophic lateral sclerosis (ALS) in Sicily, southern Italy, by means a population based study. We included people with ALS resident five Sicilian provinces, whose onset occurred the two-year period 2005-2006 (population at 31 December 2006: 3,481,096 inhabitants). A multisource case-finding procedure adopted and patients were classified as affected according revised El Escorial criteria. During surveillance period, 97 meeting eligibility...
The palmomental reflex (PMR) is a primitive that might be released due to inhibition in adulthood. It has been associated with several neurodegenerative conditions. aim of the present study was evaluate frequency PMR amyotrophic lateral sclerosis (ALS).Non-demented ALS patients (n = 179) were recruited. Two groups disease controls enrolled: (a) non-demented other neurological disorders (NC; n 86, mean age 60 ± 14 years); (b) healthy subjects, (HC; 175, 61 12 years). elicited by brisk stroke...
SUMMARY Sleep–wake problems are frequent, although unrecognized, complications of amyotrophic lateral sclerosis (ALS). Sleep disorders such as insomnia, sleep-disordered breathing and restless legs syndrome have all been reported in patients with ALS, despite the limited number studies small populations investigated so far. disturbances gradually worsen disease progression, suggesting a relationship between severity neurodegenerative process. However, poor sleep can also be consequence...
Thoracic radiculopathy is a rare cause of thoracic-abdominal or abdominal pain in subjects with poorly controlled diabetes. We present case young woman type I diabetes and severe both lower quadrants. An extensive diagnostic gastroenterological gynaecological workup did not disclose abnormalities. Electromyography revealed an initial polyneuropathy significant neurogenic abnormalities the T10-T12 paravertebral muscles. Following hypothesis that radiculopathy-related might have...
We report a patient with bulbar-onset, clinically defined, sporadic amyotrophic lateral sclerosis bearing an isolated syringomyelia of the lower thoracic portion spinal cord.This is very unusual association between two rare and progressive disorders, both affecting motoneurons.Syringomyelia might have acted as phenotypic modifier in this ALS patient.