A5024415917- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystal structures of chemical compounds
- Synthesis and biological activity
- Supramolecular Chemistry and Complexes
- Diet, Metabolism, and Disease
- Synthesis of Organic Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Liver Disease Diagnosis and Treatment
- Molecular Sensors and Ion Detection
- Synthesis and Reactions of Organic Compounds
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Multicomponent Synthesis of Heterocycles
- Magnetism in coordination complexes
- Neuroscience and Neuropharmacology Research
- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Characterization
- Analytical Chemistry and Chromatography
- Metal complexes synthesis and properties
- Axial and Atropisomeric Chirality Synthesis
Guangxi University of Chinese Medicine
2025
Nanjing Tech University
2009-2024
Nanjing Drum Tower Hospital
2022-2024
Yanbian University Hospital
2022
Yanbian University
2011-2020
Nanjing University
2001-2020
State Key Laboratory of Pharmaceutical Biotechnology
2019
Pharmaceutical Biotechnology (Czechia)
2019
ShenZhen People’s Hospital
2014-2018
University of Cambridge
2016
Oxidative stress is a critical factor in nonalcoholic fatty liver disease pathogenesis. MicroRNA-200a (miR-200a) reported to target Kelch-like ECH-associated protein 1 (Keap1), which regulates nuclear erythroid 2-related 2 (Nrf2) anti-oxidant pathway. Polydatin (3,4′,5-trihydroxy-stilbene-3-β-D-glucoside), polyphenol found the rhizome of Polygonum cuspidatum, have anti-oxidative, anti-inflammatory and anti-hyperlipidemic effects. However, whether miR-200a controls Keap1/Nrf2 pathway...
High fructose consumption is a significant risking factor for glomerular podocyte injury. However, the causes of high fructose-induced injury are still unclear. In this study, we reported novel mechanism by which induced ferroptosis, newly form programmed cell death, in We performed quantitative proteomic analysis glomeruli fructose-fed rats to identify key regulating proteins involved injury, and found that mitochondrial single-strand DNA-binding protein 1 (SSBP1) was markedly upregulated....
Abstract Pseudo‐octahedral M II 6 L 4 capsules result from the subcomponent self‐assembly of 2‐formylphenanthroline, threefold‐symmetric triamines, and octahedral metal ions. Whereas neutral tetrahedral guests most anions investigated were observed to bind within central cavity, tetraphenylborate bound on outside, with one phenyl ring pointing into cavity. This binding configuration is promoted by complementary arrangement rings intercalated guest between phenanthroline units host. The...
High fructose intake promotes hepatic lipid accumulation. Pterostilbene, a natural analogue of resveratrol found in diet berries, exhibits hepatoprotective property. Here, we studied the protection by pterostilbene against fructose-induced accumulation and explored its possible mechanism. We observed high expression microRNA-34a (miR-34a, P < 0.05) low target, sirtuin1 (Sirt1, mRNA: 0.01; protein: 0.001), with overactivation downstream sterol regulatory element-binding protein-1 (SREBP-1)...
Abstract Pseudo‐octahedral M II 6 L 4 capsules result from the subcomponent self‐assembly of 2‐formylphenanthroline, threefold‐symmetric triamines, and octahedral metal ions. Whereas neutral tetrahedral guests most anions investigated were observed to bind within central cavity, tetraphenylborate bound on outside, with one phenyl ring pointing into cavity. This binding configuration is promoted by complementary arrangement rings intercalated guest between phenanthroline units host. The...
Abstract High fructose intake is a risk factor for liver fibrosis. Polydatin main constituent of the rhizome Polygonum cuspidatum , which has been used in traditional Chinese medicine to treat However, underlying mechanisms fructose‐driven fibrosis as well actions polydatin are not fully understood. In this study, was found promote zinc finger E‐box binding homeobox 1 (ZEB1) nuclear translocation, decrease microRNA‐203 (miR‐203) expression, increase survivin, activate transforming growth β1...
The title compound, C 21 H 16 FNO 3 ·CH OH, was synthesized by the reaction of 1-naphthol with methyl cyanoacetate and 3-fluorobenzaldehyde in methanol under microwave irradiation. pyran rings two independent molecules asymmetric unit adopt boat conformations. crystal packing is stabilized intermolecular N—H...O, O—H...O C—H...π interactions.
Corticotropin-releasing factor (CRF) is an important neuromodulator in central nervous system that modulates neuronal activity via its receptors during stress responses. In cerebellar cortex, CRF the simple spike (SS) firing of Purkinje cells (PCs) has been previously demonstrated, whereas effect on molecular layer interneuron (MLI)–PC synaptic transmission still unknown. this study, we examined facial stimulation–evoked cortical MLI-PC urethane-anesthetized mice by vivo cell-attached...
GRAPHICAL ABSTRACT
The structure of the title compound, {[Cu(C2O4)(H2O)2]·H2O}n, may be described as a one-dimensional zigzag chain, constructed alternating bis-bidentate-bridged Cu atoms and oxalate groups. Two thirds water molecules coordinate to atoms, rest are present uncoordinated solvent. Intermolecular O—H⋯O hydrogen bonds link form three-dimensional supramolecular structure. atom molecule lie on twofold rotation axes, ligand lies an inversion centre.
A novel [Fe II 2 L 3 ] 4+ metallo-organic helicate results from subcomponent self-assembly of a C -symmetric triamine (4,4',4''-(1,3,5-triazine-2,4,6-triyl) trianiline), octahedral iron(II) and 2-formyl pyridine in CH CN solution.The constitution this supramolecular was confirmed by ESI-MS 1 H NMR spectra.Different planar aromatic guests were selected to investigate host-guest interactions shifts signals.The show that electron-rich molecules with matched size symmetry, such as pyrene, are...
Versatile bridging oxalates build up the delicate 3D structure, leaving cavity for a hydrogen-bonded water molecule.
The title compound, C25H21ClN2O2, was synthesized by the reaction of 5-methoxy-1H-indole and 4-chlorobenzaldehyde in ethanol using CuBr2 as a catalyst under microwave irradiation. In crystal structure, there is an intermolecular N—H⋯O hydrogen bond two C—H⋯π contacts.
Purple crystals of the title compound, cobalt dizinc phosphate tetrahydrate, have been prepared hydrothermally. It is isostructural with hopeite, Zn3(PO4)2·4H2O, completely substituted for zinc at octahedral site, resulting in [ZnPO4]− layers bridged by cis Co(H2O)4O2 octahedra. Various O—H⋯O hydrogen bonds help to stabilize structure. The Co atom and two water O atoms occupy special positions mirror symmetry,