A5021738188- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Lipid Membrane Structure and Behavior
- Neuroscience and Neuropharmacology Research
- Force Microscopy Techniques and Applications
- Silicon Nanostructures and Photoluminescence
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Cell Image Analysis Techniques
- Nanowire Synthesis and Applications
- Advanced Electron Microscopy Techniques and Applications
- Spaceflight effects on biology
- RNA and protein synthesis mechanisms
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
University of California, San Francisco
2023
Buck Institute for Research on Aging
2019-2020
Howard Hughes Medical Institute
2009-2017
Rockefeller University
2009-2017
University of Maryland, College Park
2003
Abstract The termination of a meal is controlled by dedicated neural circuits in the caudal brainstem. A key challenge to understand how these transform sensory signals generated during feeding into dynamic control behaviour. nucleus solitary tract (cNTS) first site brain where many meal-related are sensed and integrated 1–4 , but cNTS processes ingestive feedback behaviour unknown. Here we describe prolactin-releasing hormone (PRLH) GCG neurons, two principal cell types that promote...
Significance Electrical coupling through gap junctions is an important form of neuronal communication, but methods to interrogate electrical are limited. We identified the UNC-9 junction protein (innexin) as essential component a circuit that regulates social aggregation and related behaviors in Caenorhabditis elegans . By transgenic expression dominant-negative UNC-1 stomatin rescue with gain-of-function UNC-9::GFP, we selectively interrogated restored between neurons, allowing fine...
Finding a code to unravel the population of neural responses that leads distinct animal behavior has been long-standing question in field neuroscience. With recent advances machine learning, it is shown hierarchically Deep Neural Networks (DNNs) perform optimally decoding unique features out complex datasets. In this study, we utilize power DNN explore computational principles mammalian brain by exploiting Neuropixel data from Allen Brain Institute. We decode mouse visual cortex predict...
Chronic dehydration is a leading cause of morbidity for the elderly, but how aging alters fluid homeostasis system not well understood. Here, we used combination physiologic, behavioral and circuit analyses to characterize balance affected by in mice. We found that old mice have primary defect sensing producing anti-diuretic hormone vasopressin, which results chronic dehydration. Recordings manipulations thirst circuitry revealed retain ability sense systemic cues are impaired detecting...