A5100318502- Spectroscopy and Quantum Chemical Studies
- Photochemistry and Electron Transfer Studies
- Photoreceptor and optogenetics research
- Advanced Electron Microscopy Techniques and Applications
- Photorefractive and Nonlinear Optics
- Magnetic properties of thin films
- RNA Interference and Gene Delivery
- Magnetic Properties and Applications
- Photonic and Optical Devices
- Immunotherapy and Immune Responses
- Diamond and Carbon-based Materials Research
- Thermal properties of materials
- Photosynthetic Processes and Mechanisms
- ATP Synthase and ATPases Research
- Power System Reliability and Maintenance
- Metabolomics and Mass Spectrometry Studies
- Electrical Contact Performance and Analysis
- Vacuum and Plasma Arcs
- Traditional Chinese Medicine Studies
- Antimicrobial Peptides and Activities
- Virus-based gene therapy research
- Protein Structure and Dynamics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Molecular spectroscopy and chirality
- Biochemical and Molecular Research
Sungkyunkwan University
2018-2025
Ewha Womans University
2016-2018
University of Rochester
2013-2017
Sookmyung Women's University
2016
Korea University
2008
Korea Basic Science Institute
2008
Dongguk University
2004-2005
Nitrile- and thiocyanate-derivatized amino acids have been found to be useful IR probes for investigating their local electrostatic environments in proteins. To shed light on the CN stretch frequency shift spectral lineshape change induced by interactions with hydrogen-bonding solvent molecules, we carried out both classical quantum mechanical/molecular mechanical (QM/MM) molecular dynamics (MD) simulations MeCN MeSCN water. These QM/MM conventional force field MD simulation results were...
β-Azidoalanine dipeptide 1 was synthesized, and its azido stretching vibration in H2O dimethyl sulfoxide (DMSO) studied by using Fourier transform (FT) IR spectroscopy. The dipole strength of the stretch mode is found to be about 19 5 times larger than those CN SCN modes, respectively, which have been used as local environmental sensors. band blue-shifted 14 cm−1 comparison that DMSO, indicative sensitivity electrostatic environment. To test utility β-azidoalanine an probe environment...
The first step of photosynthesis is the absorption light by antenna complexes. Recent studies light-harvesting complexes using two-dimensional electronic spectroscopy have revealed interesting coherent oscillations. Some contributions to those coherences are assigned coherence and therefore implications for theories energy transfer. To assign these femtosecond data gain insight into interplay among vibrational resonances, we need detailed information on vibrations in excited state compared...
Structure-based drug design (SBDD) has gained popularity owing to its ability develop more potent drugs compared conventional drug-discovery methods. The success of SBDD relies heavily on obtaining the three-dimensional structures targets. X-ray crystallography is primary method used for solving and aiding workflow; however, it not suitable all With resolution revolution, enabling routine high-resolution reconstruction structures, cryogenic electron microscopy (cryo-EM) emerged as a...
Cryogenic electron microscopy (cryo-EM) has revolutionized structural biology by enabling the study of macromolecular structures in near-native conditions, suspended vitreous ice. This technique allows for high-resolution visualization proteins and other biomolecules without need crystallization, offering significant insights into their function mechanism. Recent advancements single-particle analysis, coupled with improved computational data processing, have made cryo-EM an indispensable...
The ultrafast dynamics of 2'-deoxyguanosine 5'-monophosphate after excitation with ultraviolet light has been studied femtosecond transient absorption (TA) and stimulated Raman spectroscopy (FSRS). TA kinetics anisotropy spectra reveal a rapid relaxation from the Franck-Condon region, producing an extremely red-shifted emission band at ∼440 nm that is formed 200 fs subsequent for 0.8-1.5 ps, consistent prior studies. Viscosity dependence shows initial relaxation, before 0.5 same in water or...
Melanoma, one of the aggressive cancers, is known to be resistant chemotherapy. Because its nature, effectively inducing apoptosis necessary treat melanoma. Erythroid differentiation regulator 1 (Erdr1) a stress-related survival factor exhibiting anti-cancer effects in several cancers. However, little about functions and underlying mechanisms Erdr1 so far. To demonstrate effect melanoma apoptosis, recombinant murine was injected into mice implanted with B16F10 cells. In vivo tumor growth...
Femtosecond stimulated Raman spectroscopy (FSRS) has emerged as a powerful new technique that is capable of obtaining resonance spectra fluorescent species and transient photochemical intermediates. Unlike related infrared absorption techniques, the FSRS signal quite sensitive to laser power utilized in vibrational probing event. In particular, are highly intensity picosecond Raman‐pump pulse. We have measured dependence using pulse energies from ~10 −9 −5 J molecules with range molar...
Carrier peptides, termed protein transduction domains (PTDs), serve as provide promising vehicles for intranasal delivery of macromolecular drugs. A mutant PTD derived from human translationally controlled tumor (TCTP-PTD 13, MIIFRALISHKK) was reported to enhanced insulin. In this study, we tested whether its efficiency could be further improved by replacing amino acids in TCTP-PTD 13 or changing the carrier peptides l- d-form. We assessed pharmacokinetics PTD-mediated transmucosal insulin...
Nasal vaccination offers a promising alternative to intramuscular (i.m.) because it can induce both mucosal and systemic immunity. However, its major drawback is poor absorption of large antigens in the nasal epithelium. Protein transduction domains (PTDs), also called cell-penetrating peptides, have been proposed as vehicles for delivery therapeutic peptides proteins. Here, we evaluated potential mutant PTD derived from translationally controlled tumor protein (designated TCTP-PTD 13) an...
Abstract : Most human metabolomics studies have shown that spectral outputs of We recruited 30 male college students to evaluate the factors affecting intra- and inter-individual variations in urinary endogenous metabolites. Statistical analysis for metabolites was performed after eliminating outliers found principal component (PCA) plots. Inter-individual were relatively low 2-oxoglutarate, succinate, citrate, dimethylglycine, taurine, but high trimethylaminoxide (TMAO), hippurate, lactate....
One of the major concerns regarding data detection in holographic storage systems is overcoming interpage interference (IPI). In general, IPI can be reduced by making number 1 (light) and 0 (dark) pixels same a recorded page to have as many transitions possible produced each row column. Such requirements satisfied guided scrambling (GS) method. this paper, we investigate optimum control bits form page.
We present a rate 5/9 pseudo-balanced code with two-dimensional (2D) 3×3 arrays. Although this has high compared to other 2D 4/9, detection performances of two codes are similar.
The non-controlled closing of High-voltage SF6 gas circuit breaker can cause transient current and overvoltage in the field. controlled technology is an effective way to reduce voltage, prevent equipment failures, improve power quality. For development closing, it obviously necessary determine withstand voltage between arc contacts making operation. This paper focuses on decrease pressure density that affect dielectric strength could be improved by minimizing decrement obtained simulation...