A5012281126- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Sleep and Wakefulness Research
- Cannabis and Cannabinoid Research
- Mesenchymal stem cell research
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Acupuncture Treatment Research Studies
- Neuroscience of respiration and sleep
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Pluripotent Stem Cells Research
- Anesthesia and Pain Management
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
Rutgers, The State University of New Jersey
2015-2024
Rutgers New Jersey Medical School
2005-2022
RWTH Aachen University
2021
Society for Neuroscience
2019
University Hospital, Newark
2005-2011
Universitat de València
2011
McGill University
2011
American Society of Anesthesiologists
2011
Abstract Mesenchymal stem cells (MSCs) exhibit immune-suppressive properties, follow a pattern of multilineage differentiation, and transdifferentiation potential. Ease in expansion from adult bone marrow, as well its separation ethical issues, makes MSCs appealing for clinical application. treated with retinoic acid resulted synaptic transmission, based on immunostaining synaptophysin electrophysiological studies. In situ hybridization indicated that the neurotransmitter gene...
GABA-mediated postsynaptic currents (IPSCs) were recorded from dopaminergic (DA) neurons of the ventral tegmental area (VTA) rats, in acute brain slices, and enzymatically or mechanically dissociated neurons. In young rats (3-10 d age), where GABA is excitatory, glycine (1-3 μ m ) taurine (10-30 increased amplitude evoked IPSCs (eIPSCs) frequency spontaneous (sIPSCs) but had minimal effects. Strychnine (1 blocked action glycine; when applied alone, it reduced eIPSCs sIPSCs, indicating a...
Mesenchymal stem cells (MSCs) are mesoderm-derived cells, primarily resident in adult bone marrow (BM). MSCs exhibit lineage differentiation to generate such as BM stroma, fat, and cartilage. Recent studies have reported the transdifferentiation of ectodermal endodermal origin. Previously, we human (h) into neuronal using retinoic acid (RA) a differentiating agent. This study presents more efficient induction method rigorously characterizes development molecular, cellular, functional...
The neurons responsible for the onset of sleep are thought to be located in ventrolateral preoptic nucleus (VLPO), which receives a dense histaminergic innervation from tuberomammillary (TMN). Yet, role histamine VLPO remains unclear. Here we report that microinjection into increases motor activity rats. Moreover, bath application acute brain slices inhibits majority neurons, also inhibited by noradrenaline. Histamine hyperpolarizes membrane potential and lowers firing rate. These effects...
The lateral habenula (LHb) is bilaterally connected with serotoninergic raphe nuclei, and expresses high density of serotonin receptors. However, actions on the excitatory synaptic transmission to LHb neurons have not been thoroughly investigated. contains two anatomically functionally distinct regions: (LHbl) medial (LHbm) divisions. We compared serotonin's effects glutamatergic across in rat brains. Serotonin bi-directionally differentially modulated transmission. inhibited higher...
Abstract Hyperalgesia often occurs in alcoholics, especially during abstinence, yet the underlying mechanisms remain elusive. The lateral habenula (LHb) has been implicated pathophysiology of pain and alcohol use disorders. Suppression m-type potassium channels (M-channels) found to contribute hyperactivity LHb neurons rats withdrawn from chronic administration. Here, we provided evidence that M-channels may hyperalgesia. Compared naïve counterparts, male Long-Evans at 24-hours withdrawal...
Abstract Hyperalgesia, which often occurs in people suffering from alcohol use disorder, may drive excessive drinking and relapse. Emerging evidence suggests that the lateral habenula (LHb) play a significant role this condition. Previous research endocannabinoid signaling (eCBs) is involved drug addiction pain, LHb contains core components of eCBs machinery. We report here our findings rats subjected to chronic ethanol vapor exposure. detected substantial increase endocannabinoid-related...
Previous studies in vivo have shown that salsolinol, the condensation product of acetaldehyde and dopamine, has properties may contribute to alcohol abuse. Although opioid receptors, especially μ-opioid receptors (MORs), be involved, cellular mechanisms mediating effects salsolinol not been fully explored. In current study, we used whole-cell patch-clamp recordings examine on dopamine neurons ventral tegmental area (VTA) acute brain slices from Sprague-Dawley rats. Salsolinol (0.01–1 μM)...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Recent rat studies indicate that alcohol withdrawal can trigger a negative emotional state including anxiety- and depression-like behaviors hyperalgesia, as well elevated glutamatergic transmission activity in lateral habenula neurons. TRPV1, vanilloid receptor expressed the habenula, is involved pain, dependence, transmission. The authors therefore hypothesized TRPV1 contributes to...
It is known that the posterior ventral tegmental area (p-VTA) differs from anterior VTA (a-VTA) in rats learn to self-administer ethanol into p-VTA, but not a-VTA. Because activation of dopaminergic neurons by a cellular mechanism underlying reinforcement consumption, we hypothesized may exert different effects on p-VTA and In patch-clamp recordings midbrain slices young (postnatal days 22-32), detected no significant difference electrophysiological properties between a-VTA neurons. However,...
Background The aversive properties of ethanol (EtOH) that limit its intake are poorly understood. There is an increasing interest in the role rostromedial tegmental nucleus (RMTg), because it encodes aversion signals and inhibits motivated behaviors. It also a major source inhibitory GABAergic inputs to midbrain dopamine neurons. Up this time, RMTg EtOH-drinking behaviors has not been well explored. Methods Male Long–Evans rats were trained either drink EtOH under intermittent...