A5051601023- Alcoholism and Thiamine Deficiency
- Neurological and metabolic disorders
- Infectious Encephalopathies and Encephalitis
- Pharmaceutical Practices and Patient Outcomes
- Schizophrenia research and treatment
- Diet and metabolism studies
- Pharmacy and Medical Practices
- Vitamin C and Antioxidants Research
- Folate and B Vitamins Research
- Palliative Care and End-of-Life Issues
- Hepatitis C virus research
- Biomedical Text Mining and Ontologies
- Head and Neck Cancer Studies
- Systemic Lupus Erythematosus Research
- Electroconvulsive Therapy Studies
- Dementia and Cognitive Impairment Research
- Oral health in cancer treatment
- Multiple Myeloma Research and Treatments
- Biochemical Acid Research Studies
- Cancer survivorship and care
- Neurosurgical Procedures and Complications
- Liver Disease Diagnosis and Treatment
- Spinal Hematomas and Complications
- Cancer-related cognitive impairment studies
- Ocular Surface and Contact Lens
Nagasaki University
2021-2025
Asahikawa Medical University
2015-2025
Kyoto University
2016-2023
Saitama Medical University
2023
Mitsubishi Kyoto Hospital
2023
Ono Clinic
2023
Maruyama Memorial General Hospital
2023
Keihin (Japan)
2017-2020
Rutgers, The State University of New Jersey
2018
National Center for Global Health and Medicine
2014-2016
Objective There is some evidence that clozapine significantly underutilised. Also, use thought to vary by country, but so far no international study has assessed trends in prescribing. Therefore, this aimed assess on an scale, using standardised criteria for data analysis. Method A repeated cross‐sectional design was applied extracts (2005–2014) from 17 countries worldwide. Results In 2014, overall prevalence greatest Finland (189.2/100 000 persons) and New Zealand (116.3/100 000), lowest...
ABSTRACT Objective The global prevalence of nontuberculous mycobacterial pulmonary disease (NTM‐PD) has been steadily increasing. A few small retrospective studies have reported a poor prognosis associated with chronic aspergillosis (CPA) as complication NTM‐PD. Furthermore, the prognostic impact CPA may inadequately assessed due to differences in background factors. This study aimed identify risk factors for NTM‐PD and compare in‐hospital mortality between patients without aspergillosis....
In use of a claims database for study, an inaccurate diagnosis breast cancer based on data may lead to invalid study results. The aim this was assess the accuracy definitions identifying cases from Japanese database. cohort consisted women with no prior cancer-related history, at single institution between January 1 and December 31, 2011. We developed 14 data, using combination codes treatment procedure codes. calculated sensitivity, specificity, positive predictive value (PPV) each...
Understanding disease seasonality is important for improving clinical practice, hospital resource utilization and community-based preventive care. However, no studies have investigated the of acute kidney injury (AKI).In Tokushukai Medical Database, which includes 38 Japanese community hospitals, we identified hospitalized patients with AKI based on Kidney Disease: Improving Global Outcomes serum creatinine criteria from January 2012 to December 2014. We plotted number proportion among by...
Recent studies have revealed thiamine deficiency (TD) as a cause of delirium in cancer patients. However, the extent to which Wernicke encephalopathy is present and what patients not well understood.In this retrospective descriptive study, we investigated referred who were diagnosed with by psycho-oncologist clarify proportion TD, therapeutic effect administration, factors involved its onset.Among 71 psycho-oncologist, TD was found 45% Intravenous administration led recovery about 60% these...
Abstract Objectives Naldemedine is a peripherally acting μ-opioid receptor antagonist used to treat opioid-induced constipation. As this drug does not cross the blood–brain barrier, it believed that patients without brain metastases do experience opioid withdrawal symptoms. Methods Here, we experienced case in which cancer patient metastasis presented with anxiety and restlessness was severe enough interfere daily life. The diagnosed naldemedine-induced syndrome. Results 66-year-old male...
Abstract Background Although human immunodeficiency virus (HIV)-related peripheral neuropathies are among the most common neurological complications in patients with HIV infection, prevalence and patient characteristics of HIV-related pain neuropathic Japan remain unclear. Objectives This study aims to investigate a focus on Japanese patients. Methods We conducted survey diagnosed infection reviewed their medical records collect following information; age, sex, presence or numbness, duration...
<title>Abstract</title> <bold>Background: </bold>Colorectal cancer (CRC) is a global health concern and the first cause of cancer-related mortalities among women in Japan. Despite effectiveness fecal immunochemical tests (FITs), screening rates for colorectal Nagasaki, Japan remain suboptimal. Investigating determinants CRC awareness Nagasaki may improve screening. <bold>Methods: </bold>This study included female patients with knowledge questionnaires at facilities conducting colonoscopy...
Purpose This study aimed to assess the trends in antipsychotic prescriptions for outpatients Japan, where a community-based approach mental healthcare is emphasized. Methods descriptive epidemiological used claims data from 1038 community pharmacies across Japan. Outpatients who were ≥18 years old and receiving their initial prescription during 2006–2012 evaluated. The annual reported monotherapies, polypharmacy, doses, concurrent of psychotropic medications. Results 152 592 included 101 133...
Previous studies have reported that diabetes is a risk factor for both all-cause and vascular dementia; however, as Alzheimer's disease (AD) remains controversial. Therefore, the aim was to elucidate association between early-onset AD.A case-control study conducted using population-based database included medical pharmacy claims insurance eligibility data, from beneficiaries of corporate employees their dependent family members. Cases were aged 40-64 years first prescribed medications AD...
目的:バリデーション研究は,医療情報データベース (DB) を用いる研究・製造販売後調査の信頼性を高めるために必要となることがある.日本薬剤疫学会はタスクフォースを設置し,日本でのバリデーション研究の在り方を検討した.
Placebo effect is one of the methodological difficulties in dry eye clinical trials. If we could elucidate tendencies placebo response and find predictors, reduce trials for eye. In this study, investigated predictive factors trials.A total 205 patients with assigned to arms three placebo-controlled randomised were analysed by simple multivariable regression analysis. The corneal fluorescein (FL) staining score symptoms studied at week 4. variables interest included gender, age,...
Although four kinds of Alzheimer's disease (AD) drugs are available at present there was only one drug until 2011 in Japan. This study aimed to elucidate prescription trends these medications for AD Japanese outpatients before and after the new releases 2011.This descriptive pharmacy claims databases analyzed outpatient data from community pharmacies across The patients were 20 years or older first administered (donepezil, memantine, rivastigmine, galantamine) between January 2010 September...
Although interferon (IFN) treatment in elderly patients with chronic hepatitis C virus (HCV) infection has increased the aging Japanese population, few studies have examined efficacy and safety of IFN this population. We investigated HCV using Interferon Database.Records 36 prefectures Japan from December 2009 to April 2013 were examined. Patients who received selected. compared sustained virological response (SVR) rate withdrawal proportion among (≥75 years) those younger (<65 years, 65-74...
Abstract Background Several neuraxial techniques have demonstrated effective post-cesarean section analgesia. According to previous reports, it is likely that patient-controlled epidural analgesia (PCEA) without opioids inferior intrathecal morphine (IM) alone for However, little known whether adding PCEA IM or not. The aim of this study was compare between with and alone. Methods Fifty patients undergoing elective cesarean were enrolled in prospective randomized study. Patients one two...
Although thiamine deficiency (TD) can lead to Wernicke encephalopathy, the characteristics associated with TD in elderly have not yet been clarified. We sought clarify frequency of among an institutionalized population a controlled dietary intake and identify possible factors related TD.
In this article we describe our study of assistance for family decisions and caregiving by Japanese home care nurses to families elderly relatives at the end life. The participants were 31 who had been evaluated as providing good end-of-life care. We carried out semistructured interviews concerning practice support in two cases (cancer noncancer). conducted a qualitative analysis using constant comparative approach derived several categories inductively. Home are responsible (a) estimating...
Determination of the incidence rate diabetic ketoacidosis (DKA) in type 2 diabetes mellitus (T2DM) is urgent, response to safety issue with use glucose lowering drugs, sodium-glucose cotransporter-2 inhibitors, and DKA.We extracted data adult patients T2DM from a medical claims database Japan, which included 1 million individuals. The study period was 2005-2013, before era inhibitors. inclusion criteria were diagnosis who had at least prescription for glucose-lowering drug. We further...
Worldwide, pediatric sedation for magnetic resonance imaging is a standard practice; however, there are few studies on its trends and patterns.This study aimed to investigate the patterns of in Japan determine incidence risk factors adverse events/interventions.This longitudinal descriptive assessed children (age < 15 years) who underwent between April 2012 December 2019 using nationwide claims database. We patients' demographic characteristics, time sedatives, sedative by age,...
Abstract Objective Wernicke encephalopathy (WE) is a neuropsychiatric disorder caused by thiamine deficiency. It recognized in various stages of the cancer trajectory but has not previously been during nivolumab treatment. Method From series WE patients with cancer, we report lung patient who developed treatment nivolumab. Result A 78-year-old woman was referred to our psycho-oncology clinic because depressed mood. Psychiatric examination revealed disorientation time, date, and place, which...
Patients with schizophrenia often experience problems associated ordinary exercises of life due to their mental symptoms. Those experiencing related feeding behavior, in particular, are considered be susceptible developing Wernicke encephalopathy a deficiency thiamine, the physiological stores which limited; however, there few reported cases, and most them were accompanied by classical triad signs. We report our asymptomatic thiamine (TD) patient. A 73-year-old female was receiving...