A5025699145- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Multiple Myeloma Research and Treatments
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Evolution and Genetic Dynamics
- Gut microbiota and health
- thermodynamics and calorimetric analyses
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Bacterial Genetics and Biotechnology
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Nonlinear Dynamics and Pattern Formation
- CAR-T cell therapy research
Laboratoire des Sciences du Numérique de Nantes
2023-2025
Nantes Université
2023-2025
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2023-2025
Université d'Angers
2023
Inserm
2023
École Centrale de Nantes
2023
Centre National de la Recherche Scientifique
2017-2023
Nutrition et obésité : approches systémiques
2021
Laboratoire Interdisciplinaire de Physique
2016-2017
Centre Inria de l'Université Grenoble Alpes
2017
Ribosomes are responsible for the synthesis of proteins, major component cellular biomass. Classical experiments have established a linear relationship between fraction resources invested in ribosomal proteins and rate balanced growth microbial population. Very little is known, however, about how investment ribosomes varies over individual cells We therefore extended study resource allocation from populations to single cells, using combination time-lapse fluorescence microscopy statistical...
Microbial physiology exhibits growth laws that relate the macromolecular composition of cell to rate. Recent work has shown these empirical regularities can be derived from coarse-grained models resource allocation. While studies focus on steady-state growth, such conditions are rarely found in natural habitats, where microorganisms continually challenged by environmental fluctuations. The aim this paper is extend study microbial strategies dynamical environments, using a self-replicator...
Abstract Marine microorganisms form complex communities of interacting organisms that influence central ecosystem functions in the ocean such as primary production and nutrient cycling. Identifying mechanisms controlling their assembly activities is a major challenge microbial ecology. Here, we integrated Tara Oceans meta-omics data to predict genome-scale community interactions within prokaryotic assemblages euphotic ocean. A global genome-resolved co-activity network revealed significant...
Dietary intervention is a cornerstone of weight loss therapies. In obesity, dysbiotic gut microbiota (GM) characterized by high levels Bacteroides lineages and low diversity. We examined the GM composition changes, including 2 enterotype (Bact2), in real-world study subjects following high-protein hypocaloric diet with or without live microorganisms (LMP) supplement.263 volunteers were part this program. The first phase was low-carbohydrate calorie restriction LMP supplements. Fecal samples...
Abstract Ribosomes are responsible for the synthesis of proteins, major component cellular biomass. Classical experiments have established a linear relationship between fraction resources invested in ribosomal proteins and rate balanced growth microbial population. We extended study resource allocation from populations to single cells, using combination time-lapse fluorescence microscopy statistical inference. found large variability ribosome concentrations rates conditions model bacterium...
Abstract Marine microorganisms form complex communities of interacting organisms that influence central ecosystem functions in the ocean such as primary production and nutrient cycling. Identifying mechanisms controlling their assembly activities is a major challenge microbial ecology. Here, we integrated Tara Oceans meta-omics data to predict genome-scale community interactions within prokaryotic assemblages euphotic ocean. A global genome-resolved co-activity network revealed significant...
Abstract Bispecific antibodies targeting CD3 on T cells and GPRC5D plasma (talquetamab) demonstrated promising efficacy in multiple myeloma, but acquired resistance usually occurs within a few months. Using single-nucleus multi-omic strategy 3 patients with talquetamab resistance, we identified two mechanisms of inactivation, by bi-allelic genetic or long-range epigenetic silencing its promoter enhancer regions. Investigating the molecular profiles target genes may help guiding choice...
Background: Bispecific antibodies (BsAb) are monoclonal that redirect T cells by targeting both the cell co-receptor CD3 and markers expressed on surface of tumor cells. BsAb BCMA (teclistamab) or GPRC5D (talquetamab) demonstrated promising efficacy in relapsed refractory multiple myeloma (RRMM) recent phase 1-2 studies. However, ~30% patients did not respond, half responders experienced disease progression within 12 months. Thus, it is crucial to understand mechanisms innate acquired...
Fermenting S. cerevisiae cells suspensions undergo synchronized metabolic oscillations whose amplitude and frequency depends on the population density.The asymptotic population-level dynamics is qualitatively quantitatively accounted for by mathematical models describing intracellular glycolytic coupling through external medium.Such dynamical systems often display low-dimensional parameters that fit experimental observations.However, high dimensionality of chemical space possible existence...