A5077284311- Genetics, Aging, and Longevity in Model Organisms
- Dietary Effects on Health
- Diet and metabolism studies
- Fungal and yeast genetics research
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Adipose Tissue and Metabolism
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Contact Dermatitis and Allergies
- Forensic and Genetic Research
- Congenital heart defects research
- RNA and protein synthesis mechanisms
- Metabolism and Genetic Disorders
- BRCA gene mutations in cancer
- Transgenic Plants and Applications
- FOXO transcription factor regulation
- Genomic variations and chromosomal abnormalities
- Diet, Metabolism, and Disease
- Child Development and Digital Technology
- Endoplasmic Reticulum Stress and Disease
- Protein Kinase Regulation and GTPase Signaling
- Cancer Genomics and Diagnostics
University of Palermo
2014-2023
University of Southern Denmark
2019
University of Calabria
2019
University of Bari Aldo Moro
2019
Multidisciplinary Digital Publishing Institute (Switzerland)
2019
University of Southern California
2012-2014
Human Longevity (United States)
2014
Southern California University for Professional Studies
2012
Instituto di Biofisica
1994-2000
European Molecular Biology Laboratory
1992-1993
Dietary restriction extends longevity in organisms ranging from bacteria to mice and protects primates a variety of diseases, but the contribution each dietary component aging is poorly understood. Here we demonstrate that glucose specific amino acids promote stress sensitization through differential activation Ras/cAMP/PKA, PKH1/2 Tor/S6K pathways. Whereas sensitized cells Ras-dependent mechanism, threonine valine promoted cellular primarily by activating pathway serine via PDK1 orthologs...
Summary In mammals, extended periods of fasting leads to the accumulation blood ketone bodies including acetoacetate. Here we show that similar conversion leucine acetoacetate in starvation conditions induced body‐like acetic acid generation from S. cerevisiae . Whereas wild‐type and ras2Δ cells accumulated acid, long‐lived tor1Δ sch9Δ mutants rapidly depleted it through a mitochondrial acetate CoA transferase‐dependent mechanism, which was essential for lifespan extension. The sch9...
A clone (P2) coding for an allergen of Parietaria judaica (Pj) pollen has been isolated and sequenced from a cDNA library in lambda ZAP using pool 23 sera Pj‐allergic patients. The contained insert 622 nucleotides with open reading frame 133 amino acids (aa) putative signal peptide 31 aa giving deduced mature processed protein 102 molecular mass 11 344 Da. expressed recombinant protein, named rPar j 2.0101, was major since it reacted IgE 82% (23/28) the subjects analyzed. It shown to be new...
Abstract Par j 1.0101 is one of the two major allergens Parietaria judaica (Pj) pollen, and its three-dimensional structure was built by structural homology modeling. The resultant model used to identify putative IgE binding regions. Western blot analysis gene fragmentation products showed that 1 30 region capable specific from a pool sera (n = 30) patients allergic Pj pollen. Using as guide, deletion site-directed mutagenesis performed, amino acids involved in were identified. In addition,...
Background: The circulating tumor DNA (ctDNA) diagnostic accuracy for detecting phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA) mutations in breast cancer (BC) is under discussion. We aimed to compare plasma and tissue PIK3CA alterations, encompassing factors that could affect the results. Methods: Two reviewers selected studies from different databases until December 2020. considered BC patients with matched ctDNA. performed meta-regression subgroup analyses...