A5066660725- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Child Nutrition and Feeding Issues
- Obstructive Sleep Apnea Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Sleep and Wakefulness Research
- Pneumonia and Respiratory Infections
- Epilepsy research and treatment
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Circadian rhythm and melatonin
- Infant Development and Preterm Care
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- EEG and Brain-Computer Interfaces
- Pediatric health and respiratory diseases
- Family and Disability Support Research
- Pleural and Pulmonary Diseases
- Sleep and Work-Related Fatigue
- Immunodeficiency and Autoimmune Disorders
Hadassah Medical Center
2016-2025
Hebrew University of Jerusalem
2019-2024
University Medical Center
2017-2023
University Hospital and Clinics
2023
Hadassah Academic College
2019-2023
GTx (United States)
2014-2022
In-Q-Tel
2021-2022
University of Rochester
2022
Beth Israel Deaconess Medical Center
2015-2016
Boston Children's Hospital
2014-2015
Study Objectives: The stress imposed by the COVID-19 pandemic and ensuing social isolation could adversely affect sleep.As sleep problems may persist hurt health, it is important to identify which populations have experienced changes in sleeping patterns during their extent.Methods: In 1, 3,062 responders from 49 countries accessed survey website voluntarily between March 26 April 26, 2020, 2,562 (84%; age: 45.2 ± 14.5, 68% women) completed study.In 2, 1,022 adult US were recruited for pay...
Plasmids p749, p106, and p150 contain cDNA inserts complementary to rat skeletal muscle actin mRNA. Nucleotide sequence analysis indicates the following relationships: p749 specifies codons 171 360; 357 374 together with 120 nucleotides of 3'-non-translated region; p106 last amino acid codon, termination codon entire 3' non-translated region. Plasmid hybridized RNA extracted from muscle, cardiac smooth (stomach) brain. It also hybridizes well brain dog chick. specifically striated muscles...
Insufficient sleep affects circadian hormonal profiles and inflammatory markers may modulate attention, executive functioning decision-making. Medical professionals specifically resident physicians, who are involved in long-term nightshift schedules during their post-graduate training, prone to acute chronic deprivation disruption, putting them at risk for making medical errors. The aim of the study was evaluate impact acute-on-chronic disruption among residents on selected physiological...
Antisense oligonucleotide (ASO)-based drugs for splicing modulation were recently approved various genetic diseases with unmet need. Here we aimed to develop an ASO-based therapy Cystic Fibrosis (CF) patients carrying the 3849+10 kb C-to-T mutation in CFTR gene.We have screened, FRT cells expressing mutation, ~30 2'-O-Methyl-modified phosphorothioate ASOs, targeted prevent recognition and inclusion of a cryptic exon generated due mutation. The effect highly potent ASO candidates on pattern,...
Mesenchymal stem cells (MSCs) attenuate lung injury in experimental models of bronchopulmonary dysplasia (BPD). Stromal derived factor-1 (SDF-1), a chemokine secreted by MSCs, modulates angiogenesis and cell recruitment. Here we tested the hypothesis that SDF-1 mediates MSC protective effects BPD modulating angiogenesis. was knocked down MSCs using lentiviral vectors carrying anti-SDF-1 short hairpin RNA (MSC-SDF KD). Non-silencing used as control (MSC-NS control). Newborn rats exposed to...
We investigated the diagnostic accuracy of a nocturnal sleep onset rapid eye movement period (nSOREMP) for identification narcolepsy with cataplexy (N+C) among children and adolescents referred to laboratory an overnight polysomnography (PSG) multiple latency test (MSLT).Retrospective chart review clinic notes PSG MSLT reports.Boston Children's Hospital outpatient clinics.All patients 6-18 y old, consecutive evaluation central hypersomnias, between January 2005 2014.We analyzed records 148...
Rationale: Ivacaftor's clinical effects in the residual function mutations 3849 + 10kb C→T and D1152H warrant further characterization.Objectives: To evaluate ivacaftor's effect people with cystic fibrosis aged ≥6 years or to explore correlation between ivacaftor-induced organoid-based transmembrane conductance regulator measurements response ivacaftor.Methods: Participants were randomized (1:1) this placebo-controlled crossover study; each treatment sequence included two 8-week treatments...
Poor sleep quality, often resulting from poor hygiene, is common among medical students. Educational interventions aimed at improving knowledge are beneficial for quality in healthy populations. However, education given minimal attention school curriculums. The aim of the study was to explore whether a short educational intervention could improve knowledge, and consequently students.We recruited preclinical- clinical-stage students during 2017-2018 academic year. Students completed...
To evaluate the interrater reliability and clinical applicability of a novel MRI-based radiological staging system for osteochondritis dissecans (OCD) that incorporates short echo time GRE sequence to assess progressive ossification healing status. This retrospective HIPAA-compliant study was approved by institutional IRB. MRI exams from April 2017 December 2023 were reviewed patients undergoing diagnostic OCD evaluation. Inclusion required first with (Gradient-Recalled Echo) TSE (Turbo Spin...
To assess the frequency, severity, and determinants of residual respiratory events during continuous positive airway therapy (CPAP) for obstructive sleep apnea (OSA) as determined by device output.Subjects were consecutive OSA patients at an American Academy Sleep Medicine accredited multidisciplinary center. Inclusion criteria included CPAP use a minimum 3 months, nightly 4 hours. Compliance metrics waveform data from 217 subjects analyzed retrospectively. Events scored manually when there...
The diagnosis of primary ciliary dyskinesia (PCD) relies on clinical features and sophisticated studies. detection bi-allelic disease-causing variants confirms the diagnosis. However, a standardised genetic panel is not widely available new genes are continuously identified. To assess accuracy untargeted whole-exome sequencing (WES) as diagnostic tool for PCD, patients with symptoms highly suggestive PCD were consecutively included. Patients underwent measurement nasal nitric oxide (nNO)...