A5080921681- Malaria Research and Control
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- Stochastic processes and financial applications
- Morphological variations and asymmetry
- Soil Geostatistics and Mapping
- Viral Infections and Vectors
- Geometry and complex manifolds
- Global Maternal and Child Health
- Mathematical Dynamics and Fractals
- Stochastic processes and statistical mechanics
- Data-Driven Disease Surveillance
- Zoonotic diseases and public health
- Urban Transport and Accessibility
- advanced mathematical theories
- Electromagnetic Scattering and Analysis
- Advanced Differential Geometry Research
- Statistical and numerical algorithms
- Scientific Research and Discoveries
- Computational Drug Discovery Methods
- Mathematical Biology Tumor Growth
- Viral Infections and Outbreaks Research
- Liver Disease Diagnosis and Treatment
- Statistical Methods and Bayesian Inference
- Diverse Scientific Research Studies
The Kids Research Institute Australia
2021-2025
Curtin University
2024-2025
Princess Margaret Hospital for Children
2021-2024
Perth Children's Hospital
2021-2024
University of Oxford
2020
Imperial College London
2016-2019
King's College London
2016
SummaryBackgroundSubstantial progress has been made in reducing the burden of malaria Africa since 2000, but those gains could be jeopardised if COVID-19 pandemic affects availability key control interventions. The aim this study was to evaluate plausible effects on incidence and mortality under different levels disruption control.MethodsUsing an established set spatiotemporal Bayesian geostatistical models, we generated geospatial estimates across malaria-endemic African countries clinical...
Abstract Insecticide-treated nets (ITNs) are one of the most widespread and impactful malaria interventions in Africa, yet a spatially-resolved time series ITN coverage has never been published. Using data from multiple sources, we generate high-resolution maps access, use, nets-per-capita annually 2000 to 2020 across 40 highest-burden African countries. Our findings support several existing hypotheses: that use is high among those with discarded more quickly than official policy presumes,...
Malaria remains a leading cause of illness and death globally, with countries in sub-Saharan Africa bearing disproportionate burden. Global high-resolution maps malaria prevalence, incidence, mortality are crucial for tracking spatially heterogeneous progress against the disease to inform strategic control efforts. We present latest such maps, first since 2019, which cover years 2000-22. The accompanied by administrative-level summaries include estimated COVID-19 pandemic-related impacts on...
Background Since its inception in 2005, the President's Malaria Initiative (PMI) has played a major role reductions malaria morbidity and mortality witnessed across Africa. With status of PMI funding operations currently uncertain, this study aimed to quantify impact that fully-functioning would have on cases deaths Africa during 2025. Methods We combined detailed spatio-temporal information planned 2025 non-PMI commodity procurement distribution with Bayesian models intervention coverage...
In the thirteen years since first report of pfhrp2-deleted parasites in 2010, World Health Organization (WHO) has found that 40 47 countries surveyed worldwide have reported pfhrp2/3 gene deletions. Due to a high prevalence deletions causing false-negative HRP2 RDTs, last five years, Eritrea, Djibouti and Ethiopia switched or started switching using alternative target pan-specific-pLDH P. falciparum specific-pLDH alone combination with HRP2. However, manufacturing RDTs not been brought scale...
Abstract Background Anti-malarial drugs play a critical role in reducing malaria morbidity and mortality, but their is mediated by effectiveness. Effectiveness defined as the probability that an anti-malarial drug will successfully treat individual infected with parasites under routine health care delivery system. effectiveness (AmE) influenced resistance, quality, system patient adherence to use; its influence on burden varies through space time. Methods This study uses data from 232...
Abstract Malaria transmission in Madagascar is highly heterogeneous, exhibiting spatial, seasonal and long-term trends. Previous efforts to map malaria risk used prevalence data from Indicator Surveys. These cross-sectional surveys, conducted during the high season most recently 2013 2016, provide nationally representative but cover relatively short time frames. Conversely, monthly case are collected at health facilities suffer biases, including incomplete reporting low rates of treatment...
The implications of climate change for malaria eradication in the 21st century remain poorly resolved. Many studies have focussed on parasite and vector ecology isolation, neglecting interactions between climate, control, socioeconomic environment, including disruptive impact extreme weather. Here we integrate 25 years data burden, control interventions, factors, weather events Africa. Using a geotemporal model linked to an ensemble projections under Shared Socioeconomic Pathway 2-4.5 (SSP...
Abstract Background In the context of high malaria burden yet limited resources, Guinea’s national program adopted an innovative subnational tailoring (SNT) approach, including engagement stakeholders, data review, and analytics, to update their operational plan for 2024-2026 identify most appropriate interventions each district considering resources available. Methods triggered SNT exercise with a list decisions that could be informed local data. The established team, which determined...
Testing and treating symptomatic malaria cases is crucial for case management, but it may also prevent future illness by reducing mean infection duration. Measuring the impact of effective treatment on burden transmission via field studies or routine surveillance systems difficult potentially unethical. This project uses mathematical modeling to explore how increasing impacts prevalence incidence.
Maps of disease burden are a core tool needed for the control and elimination malaria. Reliable routine surveillance data malaria incidence, typically aggregated to administrative units, is becoming more widely available. Disaggregation regression an important model framework estimating high resolution risk maps from data. However, aggregation incidence over large, heterogeneous areas means that these underpowered complex, non-linear models. In contrast, prevalence point-surveys directly...
No studies have yet examined high-resolution shifts in the spatial patterns of human movement Australia throughout 2020 and 2021, a period coincident with repeated enactment removal varied governmental restrictions aimed at reducing community transmission SARS-CoV-2. We compared overlapping timeseries COVID-19 pandemic-related restrictions, epidemiological data on cases vaccination rates, to characterize population-level responses pandemic Australian cities. found that and/or mandatory...
We survey Brownian manifolds -manifolds that can parametrise motion -and those cannot.We consider covariances of spacetime processes, particularly when space is the sphere -geo-temporal processes.There are connections with functions negative type.
The study of covariances (or positive definite functions) on the sphere (the Earth, in our motivation) goes back to Bochner and Schoenberg (1940--42) first author (1969, 1973), among others. Extending geotemporal case (sphere cross line, for position time) was a long time an obstacle geostatistical modelling. characterisation question here raised by authors Mijatović 2016, answered Berg Porcu 2017. Extensions multiple products (of spheres lines) follows similarly (Guella, Menegatto Peron,...
We survey Brownian manifolds -- that can parametrise motion and those cannot. consider covariances of space-time processes, particularly when space is the sphere geo-temporal processes. There are connections with functions negative type.
Abstract Background Malaria risk maps are crucial for controlling and eliminating malaria by identifying areas of varying transmission risk. In the Greater Mekong Subregion, these guide interventions resource allocation. This article focuses on analysing changes in developing fine-scale using five years routine surveillance data Laos (2017–2021). The study employed from 1160 geolocated health facilities Laos, along with high-resolution environmental data. Methods A Bayesian geostatistical...
<title>Abstract</title> <bold>Background</bold> Testing and treating symptomatic malaria cases is crucial for case management, but it may also prevent future illness by reducing mean infection duration. Measuring the impact of effective treatment on burden transmission via field studies or routine surveillance systems difficult potentially unethical. This project uses mathematical modeling to explore how increasing impacts prevalence incidence.<bold>Methods</bold> Leveraging OpenMalaria...
Abstract Insecticide-treated nets (ITNs) are one of the most widespread and impactful malaria interventions in Africa, yet a spatially-resolved time series ITN coverage has never been published. Using data from multiple sources, we generate high-resolution maps access, use, nets-per-capita annually 2000 to 2020 across 40 highest-burden African countries. Our findings support several existing hypotheses: that use is high among those with discarded more quickly than official policy presumes,...